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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSD3

Summary for PSD3

Gene information	Gene symbol	PSD3
	Ensembl ID	ENSG00000156011
	Entrez ID	23362
	Gene name	pleckstrin and Sec7 domain containing 3
	Synonyms	DKFZp761K1423\|EFA6D\|EFA6R\|HCA67\|KIAA0942
	Gene type	protein_coding
	UniProtAcc	Q9NYI0

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Dataset with differentially expressed gene: PSD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.16872	8.32e-06
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.350303	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.411648	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.392456	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.460546	0.00e+00

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Expression of PSD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSD3	hsa-miR-4739	84.8015	NM_015310
PSD3	hsa-miR-3180-5p	84.6197	NM_015310
PSD3	hsa-miR-8080	84.4465	NM_206909
PSD3	hsa-miR-9-5p	84.0896	NM_015310
PSD3	hsa-miR-1321	83.9591	NM_015310
PSD3	hsa-miR-4756-5p	83.9591	NM_015310
PSD3	hsa-miR-1184	83.8697	NM_206909
PSD3	hsa-miR-5193	83.764	NM_206909
PSD3	hsa-miR-1284	83.7364	NM_015310
PSD3	hsa-miR-548ag	83.6939	NM_206909
PSD3	hsa-miR-5690	83.5937	NM_206909
PSD3	hsa-miR-580-3p	83.309	NM_206909
PSD3	hsa-miR-6875-3p	83.3016	NM_206909
PSD3	hsa-miR-4465	82.9641	NM_015310
PSD3	hsa-miR-30a-3p	82.958	NM_015310
PSD3	hsa-miR-30e-3p	82.958	NM_015310
PSD3	hsa-miR-30d-3p	82.958	NM_015310
PSD3	hsa-miR-3689b-5p	82.8227	NM_206909
PSD3	hsa-miR-3689a-5p	82.8227	NM_206909
PSD3	hsa-miR-3689e	82.8227	NM_206909
PSD3	hsa-miR-23b-5p	82.7279	NM_206909
PSD3	hsa-miR-7159-3p	82.718	NM_206909
PSD3	hsa-miR-6826-3p	82.6805	NM_206909
PSD3	hsa-miR-3929	82.4392	NM_015310
PSD3	hsa-miR-628-5p	82.4001	NM_206909
PSD3	hsa-miR-6817-3p	82.211	NM_206909
PSD3	hsa-miR-6844	82.0993	NM_015310
PSD3	hsa-miR-6512-5p	82.0796	NM_015310
PSD3	hsa-miR-6893-3p	82.034	NM_206909
PSD3	hsa-miR-135b-5p	82.0273	NM_015310
PSD3	hsa-miR-135a-5p	82.0273	NM_015310
PSD3	hsa-miR-12135	81.9932	NM_206909
PSD3	hsa-miR-4531	81.9561	NM_206909
PSD3	hsa-miR-4672	81.8586	NM_015310
PSD3	hsa-miR-370-3p	81.7239	NM_206909
PSD3	hsa-miR-7-2-3p	81.3486	NM_015310
PSD3	hsa-miR-7-1-3p	81.3486	NM_015310
PSD3	hsa-miR-3680-3p	81.2559	NM_206909
PSD3	hsa-miR-4778-5p	81.1804	NM_206909
PSD3	hsa-miR-509-3p	80.688	NM_206909
PSD3	hsa-miR-3912-5p	80.6367	NM_015310

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Motifs and transcription factors (TFs) regulating PSD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSD3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PSD3	metacluster_151.2	ZNF23 (directAnnotation).
PSD3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PSD3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PSD3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PSD3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PSD3	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PSD3	metacluster_52.11	ZNF184 (directAnnotation).
PSD3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PSD3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PSD3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PSD3	transfac_pro__M07387	ZBTB7A (directAnnotation).
PSD3	transfac_pro__M00716	ZBTB14 (directAnnotation).
PSD3	transfac_pro__M03876	ZBTB33 (directAnnotation).
PSD3	metacluster_135.11	NR2C2 (directAnnotation).
PSD3	cisbp__M00968	MTF2 (directAnnotation).
PSD3	cisbp__M00341	PAX6 (directAnnotation).
PSD3	metacluster_198.3	ZFP64 (directAnnotation).
PSD3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PSD3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PSD3	hdpi__ZNF304	ZNF304 (directAnnotation).
PSD3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PSD3	transfac_pro__M01199	TRIM28 (directAnnotation).
PSD3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PSD3	transfac_pro__M03806	ZBTB7C (directAnnotation).
PSD3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PSD3	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PSD3	transfac_pro__M02089	E2F3 (directAnnotation).
PSD3	transfac_pro__M04817	ZBTB33 (directAnnotation).
PSD3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PSD3	tfdimers__MD00483	ZBTB14 (directAnnotation).
PSD3	cisbp__M07938	E2F1 (directAnnotation).
PSD3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PSD3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."