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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHIP

Summary for PHIP

Gene information	Gene symbol	PHIP
	Ensembl ID	ENSG00000146247
	Entrez ID	55023
	Gene name	pleckstrin homology domain interacting protein
	Synonyms	BRWD2\|DCAF14\|FLJ20705\|ndrp\|WDR11
	Gene type	protein_coding
	UniProtAcc	Q8WWQ0

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Dataset with differentially expressed gene: PHIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.416874	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.260414	2.74e-08
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.288377	5.39e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.251377	1.06e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.356582	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.250536	0.00e+00

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Expression of PHIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHIP	hsa-miR-181b-5p	83.0897	NM_017934
PHIP	hsa-miR-181a-5p	83.0897	NM_017934
PHIP	hsa-miR-181c-5p	83.0897	NM_017934
PHIP	hsa-miR-4668-3p	82.6208	NM_017934
PHIP	hsa-miR-5681b	82.5696	NM_017934
PHIP	hsa-miR-381-3p	82.5366	NM_017934
PHIP	hsa-miR-300	82.5366	NM_017934
PHIP	hsa-miR-6730-5p	82.2294	NM_017934
PHIP	hsa-miR-7705	82.1214	NM_017934
PHIP	hsa-miR-654-3p	82.0918	NM_017934
PHIP	hsa-miR-4261	81.8576	NM_017934
PHIP	hsa-miR-4491	81.7168	NM_017934
PHIP	hsa-miR-4657	81.7168	NM_017934
PHIP	hsa-miR-4328	81.638	NM_017934
PHIP	hsa-miR-4436b-5p	81.4385	NM_017934
PHIP	hsa-miR-3609	81.3856	NM_017934
PHIP	hsa-miR-548ah-5p	81.3856	NM_017934
PHIP	hsa-miR-4738-3p	81.1337	NM_017934
PHIP	hsa-miR-3144-3p	80.9786	NM_017934
PHIP	hsa-miR-4791	80.6275	NM_017934
PHIP	hsa-miR-181a-2-3p	80.6025	NM_017934
PHIP	hsa-miR-548av-3p	80.5822	NM_017934
PHIP	hsa-miR-548am-3p	80.5637	NM_017934
PHIP	hsa-miR-548ae-3p	80.5637	NM_017934
PHIP	hsa-miR-548j-3p	80.5637	NM_017934
PHIP	hsa-miR-548aq-3p	80.5637	NM_017934
PHIP	hsa-miR-548ah-3p	80.5637	NM_017934
PHIP	hsa-miR-3928-5p	80.449	NM_017934
PHIP	hsa-miR-6806-3p	80.449	NM_017934
PHIP	hsa-miR-4264	80.1154	NM_017934

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Motifs and transcription factors (TFs) regulating PHIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHIP	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PHIP	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PHIP	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
PHIP	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PHIP	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PHIP	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
PHIP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PHIP	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PHIP	metacluster_3.14	WT1; WT1 (directAnnotation).
PHIP	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PHIP	cisbp__M07938	E2F1 (directAnnotation).
PHIP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PHIP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PHIP	transfac_pro__M07397	ZNF148 (directAnnotation).
PHIP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PHIP	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PHIP	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PHIP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PHIP	metacluster_7.13	ZFX (directAnnotation).
PHIP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PHIP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PHIP	transfac_pro__M01175	ZBTB7B (directAnnotation).
PHIP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PHIP	tfdimers__MD00151	CHURC1 (directAnnotation).
PHIP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PHIP	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PHIP	transfac_pro__M01303	SP1 (directAnnotation).
PHIP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PHIP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PHIP	transfac_pro__M02090	E2F4 (directAnnotation).
PHIP	transfac_pro__M01714	KLF15 (directAnnotation).
PHIP	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PHIP	jaspar__MA1122.1	TFDP1 (directAnnotation).
PHIP	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PHIP	transfac_pro__M02089	E2F3 (directAnnotation).
PHIP	transfac_pro__M12604	ZNF444 (directAnnotation).
PHIP	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PHIP	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PHIP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PHIP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PHIP	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
PHIP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PHIP	transfac_pro__M07436	WT1 (directAnnotation).
PHIP	transfac_pro__M02281	SP1 (directAnnotation).
PHIP	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PHIP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PHIP	transfac_pro__M02898	SMAD3 (directAnnotation).
PHIP	transfac_public__M00491	PATZ1 (directAnnotation).
PHIP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PHIP	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."