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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: NR3C1

Summary for NR3C1

Gene information	Gene symbol	NR3C1
	Ensembl ID	ENSG00000113580
	Entrez ID	2908
	Gene name	nuclear receptor subfamily 3 group C member 1
	Synonyms	GR\|GRL
	Gene type	protein_coding
	UniProtAcc	P04150

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Dataset with differentially expressed gene: NR3C1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.653952	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.33859	4.34e-12
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.269408	4.13e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.807776	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.336732	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.255094	6.93e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.32909	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.360348	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.396542	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.34293	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.52216	0.00e+00

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Expression of NR3C1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NR3C1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NR3C1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NR3C1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NR3C1	hsa-miR-328-3p	81.7396	NM_001204259
NR3C1	hsa-miR-6720-5p	81.6598	NM_001204259
NR3C1	hsa-miR-6512-3p	81.6598	NM_001204259
NR3C1	hsa-miR-582-5p	81.6335	NM_001204265
NR3C1	hsa-miR-380-3p	81.6141	NM_001204265
NR3C1	hsa-miR-6839-3p	81.4376	NM_001204265
NR3C1	hsa-miR-3182	81.3428	NM_001204259
NR3C1	hsa-miR-1245b-3p	81.1185	NM_001204264
NR3C1	hsa-miR-5586-5p	80.8431	NM_001204264
NR3C1	hsa-miR-937-5p	80.6687	NM_001204264
NR3C1	hsa-miR-4471	80.3788	NM_001020825
NR3C1	hsa-miR-8059	80.3788	NM_001020825
NR3C1	hsa-miR-4318	80.3344	NM_001204264
NR3C1	hsa-miR-4789-5p	80.2873	NM_001204259
NR3C1	hsa-miR-8065	80.2833	NM_001204265
NR3C1	hsa-miR-33a-3p	80.2444	NM_001204264

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Motifs and transcription factors (TFs) regulating NR3C1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NR3C1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NR3C1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NR3C1	transfac_pro__M07397	ZNF148 (directAnnotation).
NR3C1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NR3C1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NR3C1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NR3C1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NR3C1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NR3C1	metacluster_7.13	ZFX (directAnnotation).
NR3C1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NR3C1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NR3C1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NR3C1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NR3C1	tfdimers__MD00151	CHURC1 (directAnnotation).
NR3C1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NR3C1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NR3C1	transfac_pro__M01303	SP1 (directAnnotation).
NR3C1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NR3C1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NR3C1	transfac_pro__M02090	E2F4 (directAnnotation).
NR3C1	transfac_pro__M01714	KLF15 (directAnnotation).
NR3C1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NR3C1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NR3C1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NR3C1	transfac_pro__M02089	E2F3 (directAnnotation).
NR3C1	transfac_pro__M12604	ZNF444 (directAnnotation).
NR3C1	metacluster_3.14	WT1; WT1 (directAnnotation).
NR3C1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NR3C1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NR3C1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
NR3C1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NR3C1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NR3C1	cisbp__M07938	E2F1 (directAnnotation).
NR3C1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NR3C1	transfac_pro__M07436	WT1 (directAnnotation).
NR3C1	transfac_pro__M02281	SP1 (directAnnotation).
NR3C1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NR3C1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NR3C1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
NR3C1	transfac_pro__M02898	SMAD3 (directAnnotation).
NR3C1	transfac_public__M00491	PATZ1 (directAnnotation).
NR3C1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NR3C1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NR3C1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NR3C1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
NR3C1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NR3C1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NR3C1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NR3C1	cisbp__M08198	ELF1 (directAnnotation).
NR3C1	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
NR3C1	metacluster_141.5	up	Malignant cells	GSE138267	NA
NR3C1	metacluster_141.5	up	CD4+ T cells	GSE169246_PacTissue	pre
NR3C1	metacluster_141.5	down	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NR3C1	"Alclometasone"	DB00240	small molecule
NR3C1	"Aldosterone"	DB04630	small molecule
NR3C1	"Amcinonide"	DB00288	small molecule
NR3C1	"Beclomethasone dipropionate"	DB00394	small molecule
NR3C1	"Betamethasone phosphate"	DB14669	small molecule
NR3C1	"Betamethasone"	DB00443	small molecule
NR3C1	"Budesonide"	DB01222	small molecule
NR3C1	"Ciclesonide"	DB01410	small molecule
NR3C1	"Clobetasol propionate"	DB01013	small molecule
NR3C1	"Clobetasone"	DB13158	small molecule
NR3C1	"Clocortolone"	DB00838	small molecule
NR3C1	"Cortisone acetate"	DB01380	small molecule
NR3C1	"Cortivazol"	DB13003	small molecule
NR3C1	"Deflazacort"	DB11921	small molecule
NR3C1	"Desonide"	DB01260	small molecule
NR3C1	"Desoximetasone"	DB00547	small molecule
NR3C1	"Dexamethasone acetate"	DB14649	small molecule
NR3C1	"Dexamethasone"	DB01234	small molecule
NR3C1	"Diflorasone"	DB00223	small molecule
NR3C1	"Difluocortolone"	DB09095	small molecule
NR3C1	"Difluprednate"	DB06781	small molecule
NR3C1	"Drospirenone"	DB01395	small molecule
NR3C1	"Fludrocortisone"	DB00687	small molecule
NR3C1	"Flumethasone"	DB00663	small molecule
NR3C1	"Flunisolide"	DB00180	small molecule
NR3C1	"Fluocinolone acetonide"	DB00591	small molecule
NR3C1	"Fluocinonide"	DB01047	small molecule
NR3C1	"Fluorometholone"	DB00324	small molecule
NR3C1	"Fluoxymesterone"	DB01185	small molecule
NR3C1	"Flurandrenolide"	DB00846	small molecule
NR3C1	"Fluticasone furoate"	DB08906	small molecule
NR3C1	"Fluticasone propionate"	DB00588	small molecule
NR3C1	"Fluticasone"	DB13867	small molecule
NR3C1	"Gestrinone"	DB11619	small molecule
NR3C1	"Hexane-1,6-Diol"	DB02210	small molecule
NR3C1	"Hydrocortamate"	DB00769	small molecule
NR3C1	"Hydrocortisone aceponate"	DB14538	small molecule
NR3C1	"Hydrocortisone acetate"	DB14539	small molecule
NR3C1	"Hydrocortisone butyrate"	DB14540	small molecule
NR3C1	"Hydrocortisone cypionate"	DB14541	small molecule
NR3C1	"Hydrocortisone phosphate"	DB14542	small molecule
NR3C1	"Hydrocortisone probutate"	DB14543	small molecule
NR3C1	"Hydrocortisone valerate"	DB14544	small molecule
NR3C1	"Hydrocortisone"	DB00741	small molecule
NR3C1	"Levonorgestrel"	DB00367	small molecule
NR3C1	"Loteprednol etabonate"	DB14596	small molecule
NR3C1	"Medrysone"	DB00253	small molecule
NR3C1	"Megestrol acetate"	DB00351	small molecule
NR3C1	"Methylprednisolone"	DB00959	small molecule
NR3C1	"Mifepristone"	DB00834	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."