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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPATCH2L

Summary for GPATCH2L

Gene information	Gene symbol	GPATCH2L
	Ensembl ID	ENSG00000089916
	Entrez ID	55668
	Gene name	G-patch domain containing 2 like
	Synonyms	C14orf118\|FLJ10033\|FLJ20689
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GPATCH2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.324739	4.60e-33

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Expression of GPATCH2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPATCH2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPATCH2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPATCH2L	hsa-miR-337-3p	81.34	NM_001322030
GPATCH2L	hsa-miR-377-3p	81.3049	NM_001322028
GPATCH2L	hsa-miR-6761-5p	81.2368	NM_017926
GPATCH2L	hsa-miR-532-5p	81.1688	NM_001322031
GPATCH2L	hsa-miR-660-5p	81.0999	NM_001322028
GPATCH2L	hsa-miR-4719	81.0498	NM_001322029
GPATCH2L	hsa-miR-944	81.0299	NM_001322031
GPATCH2L	hsa-miR-1257	81.0135	NM_001322027
GPATCH2L	hsa-miR-548x-5p	80.9219	NM_017926
GPATCH2L	hsa-miR-548g-5p	80.9219	NM_017926
GPATCH2L	hsa-miR-548aj-5p	80.9219	NM_017926
GPATCH2L	hsa-miR-6740-3p	80.8595	NM_001322026
GPATCH2L	hsa-miR-889-3p	80.8231	NM_001322030
GPATCH2L	hsa-miR-488-3p	80.6219	NM_017926
GPATCH2L	hsa-miR-323a-3p	80.4793	NM_001322029
GPATCH2L	hsa-miR-188-3p	80.4467	NM_001322032
GPATCH2L	hsa-miR-568	80.3521	NM_001322026
GPATCH2L	hsa-miR-215-3p	80.3152	NM_017926
GPATCH2L	hsa-miR-3681-3p	80.0878	NM_001322030
GPATCH2L	hsa-miR-4660	80.0803	NM_001322027

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Motifs and transcription factors (TFs) regulating GPATCH2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPATCH2L	metacluster_7.13	ZFX (directAnnotation).
GPATCH2L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GPATCH2L	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GPATCH2L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GPATCH2L	cisbp__M00788	ZFY (inferredBy_Orthology).
GPATCH2L	metacluster_175.1	ZNF283 (directAnnotation).
GPATCH2L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GPATCH2L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GPATCH2L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GPATCH2L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GPATCH2L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."