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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DENND1B

Summary for DENND1B

Gene information	Gene symbol	DENND1B
	Ensembl ID	ENSG00000213047
	Entrez ID	163486
	Gene name	DENN domain containing 1B
	Synonyms	C1orf218\|FAM31B\|FLJ20054\|MGC27044
	Gene type	protein_coding
	UniProtAcc	Q6P3S1

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Dataset with differentially expressed gene: DENND1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.392493	0.00e+00

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Expression of DENND1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DENND1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DENND1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DENND1B	hsa-miR-548l	89.4526	NM_001195215
DENND1B	hsa-miR-323a-3p	89.3993	NM_001195216
DENND1B	hsa-miR-548au-3p	88.9654	NM_001195215
DENND1B	hsa-miR-4524b-3p	88.7573	NM_001300858
DENND1B	hsa-miR-4649-3p	88.5891	NM_001195215
DENND1B	hsa-miR-4524b-5p	88.5563	NM_001195215
DENND1B	hsa-miR-4524a-5p	88.5563	NM_001195215
DENND1B	hsa-miR-3148	88.4698	NM_001195215
DENND1B	hsa-miR-9983-3p	88.4503	NM_001195215
DENND1B	hsa-miR-374c-5p	88.1989	NM_001195216
DENND1B	hsa-miR-4762-3p	88.1856	NM_001195215
DENND1B	hsa-miR-548v	88.0175	NM_001195215
DENND1B	hsa-miR-372-5p	87.9913	NM_001195215
DENND1B	hsa-miR-3662	87.9289	NM_001195216
DENND1B	hsa-miR-6888-3p	87.6898	NM_001195215
DENND1B	hsa-miR-5688	87.6809	NM_001195216
DENND1B	hsa-miR-34b-5p	87.4936	NM_001195215
DENND1B	hsa-miR-4789-5p	87.4853	NM_001195215
DENND1B	hsa-miR-369-3p	87.3846	NM_001195216
DENND1B	hsa-miR-548ao-5p	87.2801	NM_001195215
DENND1B	hsa-miR-548ax	87.2801	NM_001195215
DENND1B	hsa-miR-4698	87.2118	NM_001195215
DENND1B	hsa-miR-1827	87.0596	NM_001195215
DENND1B	hsa-miR-649	87.042	NM_001195216
DENND1B	hsa-miR-6885-3p	87.0363	NM_001195216
DENND1B	hsa-miR-101-3p	86.7844	NM_001195216
DENND1B	hsa-miR-3671	86.7124	NM_001195215
DENND1B	hsa-let-7b-3p	86.5338	NM_001195215
DENND1B	hsa-let-7a-3p	86.5338	NM_001195215
DENND1B	hsa-miR-98-3p	86.5338	NM_001195215
DENND1B	hsa-let-7f-1-3p	86.5338	NM_001195215
DENND1B	hsa-miR-1206	86.2633	NM_001195216
DENND1B	hsa-miR-4509	85.9664	NM_001195216
DENND1B	hsa-miR-449c-5p	85.7496	NM_001195215
DENND1B	hsa-miR-2682-5p	85.6374	NM_001195215
DENND1B	hsa-miR-3140-5p	85.4368	NM_001195216
DENND1B	hsa-miR-3194-3p	85.1645	NM_001300858
DENND1B	hsa-miR-2052	85.1204	NM_001195215
DENND1B	hsa-miR-107	84.9837	NM_001195215
DENND1B	hsa-miR-103a-3p	84.9837	NM_001195215
DENND1B	hsa-miR-23b-3p	84.9508	NM_001195215
DENND1B	hsa-miR-23a-3p	84.9508	NM_001195215
DENND1B	hsa-miR-23c	84.9508	NM_001195215
DENND1B	hsa-miR-1208	84.9451	NM_001195216
DENND1B	hsa-miR-190a-3p	84.9101	NM_001195216
DENND1B	hsa-miR-498-3p	84.8035	NM_001195215
DENND1B	hsa-miR-7158-3p	84.7539	NM_001195215
DENND1B	hsa-miR-4684-3p	84.6785	NM_001195215
DENND1B	hsa-miR-1250-3p	84.6554	NM_001195215
DENND1B	hsa-miR-340-5p	84.5787	NM_001195215

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Motifs and transcription factors (TFs) regulating DENND1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DENND1B	transfac_pro__M02089	E2F3 (directAnnotation).
DENND1B	transfac_pro__M02898	SMAD3 (directAnnotation).
DENND1B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DENND1B	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
DENND1B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DENND1B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DENND1B	hdpi__HIP2	UBE2K (directAnnotation).
DENND1B	hdpi__NRL	NRL (directAnnotation).
DENND1B	transfac_pro__M00430	E2F1 (directAnnotation).
DENND1B	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
DENND1B	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
DENND1B	transfac_pro__M07329	SP7 (directAnnotation).
DENND1B	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
DENND1B	transfac_pro__M07397	ZNF148 (directAnnotation).
DENND1B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DENND1B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
DENND1B	cisbp__M07938	E2F1 (directAnnotation).
DENND1B	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DENND1B	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
DENND1B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
DENND1B	transfac_pro__M07436	WT1 (directAnnotation).
DENND1B	metacluster_3.14	WT1; WT1 (directAnnotation).
DENND1B	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
DENND1B	transfac_pro__M01837	KLF11 (directAnnotation).
DENND1B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DENND1B	transfac_pro__M07310	SP5 (directAnnotation).
DENND1B	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
DENND1B	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
DENND1B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DENND1B	transfac_pro__M04817	ZBTB33 (directAnnotation).
DENND1B	jaspar__MA0748.2	YY2 (directAnnotation).
DENND1B	swissregulon__hs__KLF6	KLF6 (directAnnotation).
DENND1B	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
DENND1B	metacluster_7.13	ZFX (directAnnotation).
DENND1B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DENND1B	transfac_pro__M00716	ZBTB14 (directAnnotation).
DENND1B	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DENND1B	jaspar__MA1122.1	TFDP1 (directAnnotation).
DENND1B	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
DENND1B	cisbp__M00968	MTF2 (directAnnotation).
DENND1B	metacluster_163.2	ZNF682 (directAnnotation).
DENND1B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DENND1B	transfac_pro__M04916	TAF1 (directAnnotation).
DENND1B	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
DENND1B	transfac_pro__M00938	E2F1 (directAnnotation).
DENND1B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DENND1B	transfac_pro__M02090	E2F4 (directAnnotation).
DENND1B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
DENND1B	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
DENND1B	swissregulon__hs__CHD1	CHD1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."