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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BRWD1

Summary for BRWD1

Gene information	Gene symbol	BRWD1
	Ensembl ID	ENSG00000185658
	Entrez ID	54014
	Gene name	bromodomain and WD repeat domain containing 1
	Synonyms	C21orf107\|DCAF19\|FLJ11315\|N143\|WDR9
	Gene type	protein_coding
	UniProtAcc	Q9NSI6

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Dataset with differentially expressed gene: BRWD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.393918	1.07e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.344188	0.00e+00

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Expression of BRWD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BRWD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BRWD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BRWD1	hsa-miR-181b-5p	82.833	NM_001007246
BRWD1	hsa-miR-6875-3p	82.2809	NM_001007246
BRWD1	hsa-miR-3662	82.0267	NM_033656
BRWD1	hsa-miR-5196-3p	82.0018	NM_033656
BRWD1	hsa-miR-9986	81.9106	NM_001007246
BRWD1	hsa-miR-1294	81.9106	NM_001007246
BRWD1	hsa-miR-4766-5p	81.5803	NM_033656
BRWD1	hsa-miR-519a-3p	81.4001	NM_033656
BRWD1	hsa-miR-519b-3p	81.4001	NM_033656
BRWD1	hsa-miR-519c-3p	81.4001	NM_033656
BRWD1	hsa-miR-20b-3p	80.7643	NM_018963
BRWD1	hsa-miR-6124	80.5177	NM_033656
BRWD1	hsa-miR-6715b-5p	80.3545	NM_033656
BRWD1	hsa-miR-4269	80.3545	NM_033656
BRWD1	hsa-miR-4282	80.1987	NM_033656
BRWD1	hsa-miR-3914	80.0247	NM_033656

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Motifs and transcription factors (TFs) regulating BRWD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BRWD1	metacluster_151.2	ZNF23 (directAnnotation).
BRWD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BRWD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BRWD1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
BRWD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BRWD1	jaspar__MA0079.5	SP1 (directAnnotation).
BRWD1	cisbp__M00341	PAX6 (directAnnotation).
BRWD1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
BRWD1	transfac_pro__M06035	ZNF749 (directAnnotation).
BRWD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BRWD1	cisbp__M07938	E2F1 (directAnnotation).
BRWD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
BRWD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
BRWD1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BRWD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BRWD1	transfac_pro__M01253	CNOT3 (directAnnotation).
BRWD1	transfac_pro__M02090	E2F4 (directAnnotation).
BRWD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BRWD1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
BRWD1	transfac_pro__M06229	ZNF91 (directAnnotation).
BRWD1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
BRWD1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
BRWD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BRWD1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
BRWD1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
BRWD1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
BRWD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BRWD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
BRWD1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BRWD1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
BRWD1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
BRWD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
BRWD1	transfac_pro__M01199	TRIM28 (directAnnotation).
BRWD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."