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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATXN1

Summary for ATXN1

Gene information	Gene symbol	ATXN1
	Ensembl ID	ENSG00000124788
	Entrez ID	6310
	Gene name	ataxin 1
	Synonyms	ATX1\|D6S504E\|SCA1
	Gene type	protein_coding
	UniProtAcc	P54253

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Dataset with differentially expressed gene: ATXN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.21438	1.80e-07
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.447452	2.38e-44
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.274614	2.20e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.315441	0.00e+00

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Expression of ATXN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATXN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATXN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATXN1	hsa-miR-1178-3p	84.2569	NM_000332
ATXN1	hsa-miR-17-5p	84.2437	NM_000332
ATXN1	hsa-miR-106a-5p	84.1145	NM_000332
ATXN1	hsa-miR-4446-5p	84.0894	NM_000332
ATXN1	hsa-miR-3191-5p	84.0053	NM_000332
ATXN1	hsa-miR-4282	83.99	NM_000332
ATXN1	hsa-miR-548t-5p	83.8759	NM_000332
ATXN1	hsa-miR-548az-5p	83.8759	NM_000332
ATXN1	hsa-miR-7154-3p	83.5969	NM_000332
ATXN1	hsa-miR-624-3p	83.5169	NM_000332
ATXN1	hsa-miR-302e	83.3213	NM_000332
ATXN1	hsa-miR-181d-5p	82.7517	NM_000332
ATXN1	hsa-miR-181b-5p	82.7517	NM_000332
ATXN1	hsa-miR-181c-5p	82.7517	NM_000332
ATXN1	hsa-miR-181a-5p	82.7517	NM_000332
ATXN1	hsa-miR-5582-3p	82.595	NM_000332
ATXN1	hsa-miR-6780a-5p	82.5226	NM_000332
ATXN1	hsa-miR-1305	82.2561	NM_000332
ATXN1	hsa-miR-639	82.233	NM_000332
ATXN1	hsa-miR-1273h-5p	82.1921	NM_000332
ATXN1	hsa-miR-30b-3p	82.1921	NM_000332
ATXN1	hsa-miR-3689b-3p	82.1921	NM_000332
ATXN1	hsa-miR-6779-5p	82.1921	NM_000332
ATXN1	hsa-miR-3689a-3p	82.1921	NM_000332
ATXN1	hsa-miR-3689c	82.1921	NM_000332
ATXN1	hsa-miR-23a-3p	82.1409	NM_000332
ATXN1	hsa-miR-23c	82.1409	NM_000332
ATXN1	hsa-miR-23b-3p	82.1409	NM_000332
ATXN1	hsa-miR-6873-3p	82.1233	NM_000332
ATXN1	hsa-miR-6881-3p	82.1095	NM_000332
ATXN1	hsa-miR-4262	82.0442	NM_000332
ATXN1	hsa-miR-4436b-5p	82.0418	NM_000332
ATXN1	hsa-miR-370-3p	81.7205	NM_000332
ATXN1	hsa-miR-7162-3p	81.5142	NM_000332
ATXN1	hsa-miR-520d-5p	81.2738	NM_000332
ATXN1	hsa-miR-524-5p	81.2738	NM_000332
ATXN1	hsa-miR-5680	81.244	NM_000332
ATXN1	hsa-miR-337-3p	81.2339	NM_000332
ATXN1	hsa-miR-627-3p	81.0616	NM_000332
ATXN1	hsa-miR-1286	80.6782	NM_000332
ATXN1	hsa-miR-152-3p	80.6664	NM_000332
ATXN1	hsa-miR-148a-3p	80.6664	NM_000332
ATXN1	hsa-miR-148b-3p	80.6664	NM_000332
ATXN1	hsa-miR-3922-3p	80.066	NM_000332

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Motifs and transcription factors (TFs) regulating ATXN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATXN1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ATXN1	transfac_pro__M06035	ZNF749 (directAnnotation).
ATXN1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ATXN1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
ATXN1	metacluster_52.11	ZNF184 (directAnnotation).
ATXN1	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
ATXN1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ATXN1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ATXN1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ATXN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ATXN1	transfac_pro__M04617	ZBTB7A (directAnnotation).
ATXN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ATXN1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ATXN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATXN1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ATXN1	transfac_pro__M07387	ZBTB7A (directAnnotation).
ATXN1	transfac_pro__M07436	WT1 (directAnnotation).
ATXN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ATXN1	transfac_pro__M00716	ZBTB14 (directAnnotation).
ATXN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ATXN1	hdpi__HIP2	UBE2K (directAnnotation).
ATXN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ATXN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ATXN1	transfac_pro__M04893	TAF1 (directAnnotation).
ATXN1	transfac_pro__M03876	ZBTB33 (directAnnotation).
ATXN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ATXN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATXN1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ATXN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATXN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ATXN1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ATXN1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
ATXN1	jaspar__MA1125.1	ZNF384 (directAnnotation).
ATXN1	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
ATXN1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ATXN1	transfac_pro__M01253	CNOT3 (directAnnotation).
ATXN1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ATXN1	transfac_pro__M02089	E2F3 (directAnnotation).
ATXN1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ATXN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATXN1	transfac_pro__M04916	TAF1 (directAnnotation).
ATXN1	transfac_pro__M12697	ZNF142 (directAnnotation).
ATXN1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ATXN1	transfac_pro__M04918	EGR1 (directAnnotation).
ATXN1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ATXN1	metacluster_7.13	ZFX (directAnnotation).
ATXN1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ATXN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATXN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATXN1	cisbp__M00249	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."