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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFHX3

Summary for ZFHX3

Gene information	Gene symbol	ZFHX3
	Ensembl ID	ENSG00000140836
	Entrez ID	463
	Gene name	zinc finger homeobox 3
	Synonyms	ATBF1\|C16orf47\|FLJ26184\|ZNF927
	Gene type	protein_coding
	UniProtAcc	Q15911

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Dataset with differentially expressed gene: ZFHX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.524208	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.322687	2.93e-11
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.532213	0.00e+00

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Expression of ZFHX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFHX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFHX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFHX3	hsa-miR-4475	88.2034	NM_001164766
ZFHX3	hsa-miR-6738-3p	88.1513	NM_001164766
ZFHX3	hsa-miR-211-5p	87.9363	NM_001164766
ZFHX3	hsa-miR-204-5p	87.9363	NM_001164766
ZFHX3	hsa-miR-580-3p	87.8037	NM_001164766
ZFHX3	hsa-miR-186-5p	87.7381	NM_001164766
ZFHX3	hsa-miR-6768-5p	87.7378	NM_001164766
ZFHX3	hsa-miR-150-3p	87.6523	NM_001164766
ZFHX3	hsa-miR-3681-3p	87.2295	NM_001164766
ZFHX3	hsa-miR-514a-3p	87.1761	NM_001164766
ZFHX3	hsa-miR-514b-3p	87.1761	NM_001164766
ZFHX3	hsa-miR-651-3p	87.0797	NM_001164766
ZFHX3	hsa-miR-6853-3p	86.8762	NM_001164766
ZFHX3	hsa-miR-605-5p	86.8671	NM_001164766
ZFHX3	hsa-miR-548ax	86.6839	NM_001164766
ZFHX3	hsa-miR-548ao-5p	86.6839	NM_001164766
ZFHX3	hsa-miR-6878-5p	86.4091	NM_001164766
ZFHX3	hsa-miR-4652-3p	85.9615	NM_001164766
ZFHX3	hsa-miR-561-3p	85.8092	NM_001164766
ZFHX3	hsa-miR-214-3p	85.5705	NM_001164766
ZFHX3	hsa-miR-761	85.5705	NM_001164766
ZFHX3	hsa-miR-5692a	85.5096	NM_001164766
ZFHX3	hsa-miR-10401-5p	85.3962	NM_001164766
ZFHX3	hsa-miR-4672	84.7639	NM_001164766
ZFHX3	hsa-miR-18a-3p	84.4344	NM_001164766
ZFHX3	hsa-miR-6737-3p	84.4314	NM_001164766
ZFHX3	hsa-miR-7157-3p	84.4314	NM_001164766
ZFHX3	hsa-miR-335-3p	84.423	NM_001164766
ZFHX3	hsa-miR-1913	84.0761	NM_001164766
ZFHX3	hsa-miR-4275	84.0446	NM_001164766
ZFHX3	hsa-miR-766-5p	83.9989	NM_001164766
ZFHX3	hsa-miR-452-3p	83.9216	NM_001164766
ZFHX3	hsa-miR-10526-3p	83.7627	NM_001164766
ZFHX3	hsa-let-7c-3p	83.6031	NM_001164766
ZFHX3	hsa-miR-3688-3p	83.3647	NM_001164766
ZFHX3	hsa-miR-875-3p	83.286	NM_001164766
ZFHX3	hsa-miR-6128	83.286	NM_001164766
ZFHX3	hsa-miR-7856-5p	83.0469	NM_001164766
ZFHX3	hsa-miR-3941	82.9607	NM_001164766
ZFHX3	hsa-miR-5008-3p	82.7931	NM_001164766
ZFHX3	hsa-miR-4668-5p	82.7271	NM_001164766
ZFHX3	hsa-miR-12136	82.6112	NM_001164766
ZFHX3	hsa-miR-577	82.3933	NM_001164766
ZFHX3	hsa-miR-641	82.3802	NM_001164766
ZFHX3	hsa-miR-3617-5p	82.3802	NM_001164766
ZFHX3	hsa-miR-6793-5p	82.2212	NM_001164766
ZFHX3	hsa-miR-331-5p	82.0858	NM_001164766
ZFHX3	hsa-miR-542-3p	81.922	NM_001164766
ZFHX3	hsa-miR-582-5p	81.5889	NM_001164766
ZFHX3	hsa-miR-9-3p	81.389	NM_001164766

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Motifs and transcription factors (TFs) regulating ZFHX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFHX3	hdpi__NFIX	NFIX (directAnnotation).
ZFHX3	transfac_pro__M03813	POU3F3 (directAnnotation).
ZFHX3	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
ZFHX3	hdpi__ZNF193	ZSCAN9 (directAnnotation).
ZFHX3	hdpi__FOXM1	FOXM1 (directAnnotation).
ZFHX3	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
ZFHX3	transfac_pro__M05768	ZNF544 (directAnnotation).
ZFHX3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZFHX3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZFHX3	transfac_pro__M07397	ZNF148 (directAnnotation).
ZFHX3	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZFHX3	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ZFHX3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ZFHX3	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZFHX3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZFHX3	metacluster_7.13	ZFX (directAnnotation).
ZFHX3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ZFHX3	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZFHX3	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZFHX3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZFHX3	tfdimers__MD00151	CHURC1 (directAnnotation).
ZFHX3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZFHX3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZFHX3	transfac_pro__M01303	SP1 (directAnnotation).
ZFHX3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZFHX3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZFHX3	transfac_pro__M02090	E2F4 (directAnnotation).
ZFHX3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZFHX3	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZFHX3	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZFHX3	transfac_pro__M02089	E2F3 (directAnnotation).
ZFHX3	metacluster_3.14	WT1; WT1 (directAnnotation).
ZFHX3	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ZFHX3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZFHX3	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZFHX3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZFHX3	cisbp__M07938	E2F1 (directAnnotation).
ZFHX3	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
ZFHX3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZFHX3	transfac_pro__M07436	WT1 (directAnnotation).
ZFHX3	transfac_pro__M02281	SP1 (directAnnotation).
ZFHX3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZFHX3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZFHX3	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ZFHX3	transfac_pro__M02898	SMAD3 (directAnnotation).
ZFHX3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ZFHX3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZFHX3	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ZFHX3	transfac_pro__M01783	SP2 (directAnnotation).
ZFHX3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."