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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZEB2

Summary for ZEB2

Gene information	Gene symbol	ZEB2
	Ensembl ID	ENSG00000169554
	Entrez ID	9839
	Gene name	zinc finger E-box binding homeobox 2
	Synonyms	KIAA0569\|SIP-1\|SIP1\|ZFHX1B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZEB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.66621	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.545847	1.77e-12
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.285239	9.21e-37
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.787848	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.357176	6.29e-16
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Mono/Macro	-0.857631	7.56e-03
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.38396	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.351238	3.24e-41
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.361456	1.09e-05
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	post	CD8+ T cells	-0.323268	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.338734	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	0.408404	2.42e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	0.295564	5.26e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.849806	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.415404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.19296	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.51489	1.48e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.847887	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.277592	1.47e-12
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.409808	6.54e-11

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Expression of ZEB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZEB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ZEB2	Regulation by the Disease Microenvironment
ZEB2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ZEB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZEB2	hsa-miR-4262	92.1752	NM_001171653
ZEB2	hsa-miR-570-5p	92.1301	NM_001171653
ZEB2	hsa-miR-548ai	92.1301	NM_001171653
ZEB2	hsa-miR-3121-3p	91.9948	NM_001171653
ZEB2	hsa-miR-219a-5p	91.9891	NM_001171653
ZEB2	hsa-miR-6766-3p	91.9891	NM_001171653
ZEB2	hsa-miR-548ag	91.9208	NM_001171653
ZEB2	hsa-miR-302f	91.8019	NM_001171653
ZEB2	hsa-miR-147a	91.4851	NM_001171653
ZEB2	hsa-miR-1179	91.2462	NM_014795
ZEB2	hsa-miR-4288	91.2185	NM_014795
ZEB2	hsa-miR-153-5p	91.1822	NM_014795
ZEB2	hsa-miR-215-5p	91.0602	NM_014795
ZEB2	hsa-miR-192-5p	91.0602	NM_014795
ZEB2	hsa-miR-518a-5p	91.0582	NM_001171653
ZEB2	hsa-miR-527	91.0582	NM_001171653
ZEB2	hsa-miR-548aa	90.4904	NM_014795
ZEB2	hsa-miR-548ap-3p	90.4904	NM_014795
ZEB2	hsa-miR-548t-3p	90.4904	NM_014795
ZEB2	hsa-miR-448	90.1816	NM_001171653
ZEB2	hsa-miR-4718	89.9772	NM_014795
ZEB2	hsa-miR-889-3p	89.6212	NM_014795
ZEB2	hsa-miR-181d-5p	89.2327	NM_001171653
ZEB2	hsa-let-7c-3p	89.183	NM_001171653
ZEB2	hsa-miR-8062	89.0858	NM_001171653
ZEB2	hsa-miR-4495	89.0848	NM_014795
ZEB2	hsa-miR-12123	89.0737	NM_001171653
ZEB2	hsa-miR-5008-5p	88.9925	NM_001171653
ZEB2	hsa-miR-498-5p	88.9887	NM_014795
ZEB2	hsa-miR-520f-5p	88.8942	NM_014795
ZEB2	hsa-miR-10522-5p	88.721	NM_001171653
ZEB2	hsa-miR-4427	88.6687	NM_014795
ZEB2	hsa-miR-8065	88.4582	NM_001171653
ZEB2	hsa-miR-548c-3p	88.2965	NM_014795
ZEB2	hsa-miR-3133	88.2043	NM_001171653
ZEB2	hsa-miR-4804-3p	88.0391	NM_014795
ZEB2	hsa-miR-4520-3p	87.9133	NM_014795
ZEB2	hsa-miR-3185	87.721	NM_001171653
ZEB2	hsa-miR-4799-5p	87.5308	NM_014795
ZEB2	hsa-miR-181a-5p	87.4905	NM_001171653
ZEB2	hsa-miR-181b-5p	87.4905	NM_001171653
ZEB2	hsa-miR-181c-5p	87.4905	NM_001171653
ZEB2	hsa-miR-302c-5p	87.3389	NM_014795
ZEB2	hsa-miR-651-3p	87.3332	NM_001171653
ZEB2	hsa-miR-12120	87.1702	NM_001171653
ZEB2	hsa-miR-3145-3p	86.7193	NM_014795
ZEB2	hsa-miR-183-3p	86.5631	NM_014795
ZEB2	hsa-miR-6818-5p	86.5514	NM_001171653
ZEB2	hsa-miR-7844-5p	86.1582	NM_001171653
ZEB2	hsa-miR-632	86.0689	NM_014795

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Motifs and transcription factors (TFs) regulating ZEB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZEB2	transfac_pro__M04860	RXRA (directAnnotation).
ZEB2	transfac_pro__M01252	E2F6 (directAnnotation).
ZEB2	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
ZEB2	metacluster_32.45	HDAC2 (directAnnotation).
ZEB2	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
ZEB2	tfdimers__MD00399	ELF5; NFATC3 (directAnnotation).
ZEB2	hocomoco__NR4A1_MOUSE.H11MO.0.B	NR4A1 (inferredBy_Orthology).
ZEB2	transfac_pro__M07284	ERG (directAnnotation).
ZEB2	hocomoco__NFAT5_HUMAN.H11MO.0.D	NFAT5 (directAnnotation).
ZEB2	transfac_pro__M05507	IKZF3 (directAnnotation).
ZEB2	metacluster_167.2	BCL11A; BCL11A; BCL11A; EP300; IKZF2; IKZF2; IRF4; IRF4; IRF4; IRF8; PRDM1; SPI1; TBL1XR1; ZBED1; ZNF41 (directAnnotation). IKZF1; IRF4; IRF4; SPI1 (inferredBy_Orthology).
ZEB2	transfac_pro__M07255	FOXM1 (directAnnotation).
ZEB2	metacluster_190.7	ILF2; NFATC1; NFATC1; NFATC1; NFATC1; NFATC2; NFATC2; NFATC2; NFATC3; NFATC3; NFATC3; NFATC3; NFATC4; NFATC4; NFATC4 (directAnnotation).
ZEB2	transfac_pro__M01281	ILF2; NFATC2 (directAnnotation).
ZEB2	hdpi__RAN	RAN (directAnnotation).
ZEB2	tfdimers__MD00109	CDX2; TAF6; TBP (directAnnotation).
ZEB2	transfac_pro__M03555	ILF2; NFATC2 (directAnnotation).
ZEB2	metacluster_32.32	PRDM6 (directAnnotation).
ZEB2	tfdimers__MD00089	STAT6 (directAnnotation).
ZEB2	swissregulon__hs__NFATC2	NFATC2 (directAnnotation).
ZEB2	transfac_pro__M07608	ILF2; NFAT5; NFATC1; NFATC2; NFATC4 (directAnnotation).
ZEB2	transfac_pro__M01886	NFATC3 (directAnnotation).
ZEB2	transfac_pro__M01250	E2F1 (directAnnotation).
ZEB2	cisbp__M11350	STAT1 (directAnnotation).
ZEB2	hocomoco__NFAC2_MOUSE.H11MO.1.C	NFATC2 (inferredBy_Orthology).
ZEB2	transfac_pro__M01279	IRF3 (directAnnotation).
ZEB2	tfdimers__MD00044	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SIRT6; SPI1; SPIB (directAnnotation).
ZEB2	hocomoco__NFKB1_HUMAN.H11MO.0.A	NFKB1 (directAnnotation).
ZEB2	transfac_pro__M07607	NFATC3 (directAnnotation).
ZEB2	transfac_pro__M05731	ZNF660 (directAnnotation).
ZEB2	c2h2_zfs__M0369	BCL6B (inferredBy_Orthology).
ZEB2	hocomoco__PRDM6_HUMAN.H11MO.0.C	PRDM6 (directAnnotation).
ZEB2	cisbp__M05891	SOX10 (directAnnotation).
ZEB2	transfac_pro__M01010	HMGA1; HMGA2 (directAnnotation).
ZEB2	transfac_pro__M06366	ZNF530 (directAnnotation).
ZEB2	transfac_pro__M05380	NR2E1 (inferredBy_Orthology).
ZEB2	transfac_pro__M07301	NFATC4 (directAnnotation).
ZEB2	hdpi__COBRA1	NELFB (directAnnotation).
ZEB2	transfac_pro__M02015	FOXA3 (directAnnotation).
ZEB2	transfac_pro__M07254	FOXC1 (directAnnotation).
ZEB2	swissregulon__hs__CUX1	CUX1 (directAnnotation).
ZEB2	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
ZEB2	hdpi__PRKRIR	THAP12 (directAnnotation).
ZEB2	transfac_pro__M06208	ZNF460 (directAnnotation).
ZEB2	cisbp__M00262	ARX (directAnnotation).
ZEB2	transfac_pro__M01183	BCL6 (directAnnotation).
ZEB2	transfac_pro__M01797	SIRT6 (directAnnotation).
ZEB2	metacluster_190.3	IKZF2; IKZF2; ILF2; NFATC1; NFATC2; NFATC3; NFATC4 (directAnnotation). NFATC2 (inferredBy_Orthology).
ZEB2	tfdimers__MD00177	STAT1; TCF7L1 (directAnnotation).
ZEB2	metacluster_130.12	ZNF182; ZNF35; ZNF674; ZNF677; ZNF79; ZNF836 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."