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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3H12C

Summary for ZC3H12C

Gene information	Gene symbol	ZC3H12C
	Ensembl ID	ENSG00000149289
	Entrez ID	85463
	Gene name	zinc finger CCCH-type containing 12C
	Synonyms	KIAA1726\|MCPIP3
	Gene type	protein_coding
	UniProtAcc	Q9C0D7

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Dataset with differentially expressed gene: ZC3H12C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.606315	0.00e+00

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Expression of ZC3H12C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC3H12C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC3H12C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3H12C	hsa-miR-6849-3p	86.4999	NM_033390
ZC3H12C	hsa-miR-885-5p	86.4336	NM_033390
ZC3H12C	hsa-miR-3686	86.4037	NM_033390
ZC3H12C	hsa-miR-664a-3p	86.1763	NM_033390
ZC3H12C	hsa-miR-29b-1-5p	86.0134	NM_033390
ZC3H12C	hsa-miR-4659a-3p	86.0032	NM_033390
ZC3H12C	hsa-miR-4659b-3p	86.0032	NM_033390
ZC3H12C	hsa-miR-6771-3p	85.8277	NM_033390
ZC3H12C	hsa-miR-376a-5p	85.7285	NM_033390
ZC3H12C	hsa-miR-548e-3p	85.5736	NM_033390
ZC3H12C	hsa-miR-548a-3p	85.5736	NM_033390
ZC3H12C	hsa-miR-548f-3p	85.5736	NM_033390
ZC3H12C	hsa-miR-548bc	85.5736	NM_033390
ZC3H12C	hsa-miR-548az-3p	85.5736	NM_033390
ZC3H12C	hsa-miR-501-3p	85.5084	NM_033390
ZC3H12C	hsa-miR-502-3p	85.5084	NM_033390
ZC3H12C	hsa-miR-4699-3p	85.4751	NM_033390
ZC3H12C	hsa-miR-4771	85.4722	NM_033390
ZC3H12C	hsa-miR-182-5p	85.4363	NM_033390
ZC3H12C	hsa-miR-5093	85.3532	NM_033390
ZC3H12C	hsa-miR-144-3p	85.1353	NM_033390
ZC3H12C	hsa-miR-188-5p	85.0939	NM_033390
ZC3H12C	hsa-miR-6866-3p	85.0939	NM_033390
ZC3H12C	hsa-miR-4735-5p	85.0545	NM_033390
ZC3H12C	hsa-miR-6124	84.9507	NM_033390
ZC3H12C	hsa-miR-600	83.9753	NM_033390
ZC3H12C	hsa-miR-4773	83.909	NM_033390
ZC3H12C	hsa-miR-337-3p	83.8472	NM_033390
ZC3H12C	hsa-miR-641	82.9704	NM_033390
ZC3H12C	hsa-miR-3617-5p	82.9704	NM_033390
ZC3H12C	hsa-miR-5590-5p	82.803	NM_033390
ZC3H12C	hsa-miR-4803	82.5329	NM_033390
ZC3H12C	hsa-miR-4712-5p	82.1311	NM_033390
ZC3H12C	hsa-miR-770-5p	82.1311	NM_033390
ZC3H12C	hsa-miR-3120-3p	82.0229	NM_033390
ZC3H12C	hsa-miR-1537-5p	81.9745	NM_033390
ZC3H12C	hsa-miR-3662	81.7434	NM_033390
ZC3H12C	hsa-miR-3143	81.676	NM_033390
ZC3H12C	hsa-miR-33b-5p	81.5364	NM_033390
ZC3H12C	hsa-miR-33a-5p	81.5364	NM_033390
ZC3H12C	hsa-miR-3671	81.511	NM_033390
ZC3H12C	hsa-miR-4683	81.2825	NM_033390
ZC3H12C	hsa-miR-10399-5p	81.0214	NM_033390
ZC3H12C	hsa-miR-12128	80.9005	NM_033390
ZC3H12C	hsa-miR-4423-5p	80.8626	NM_033390
ZC3H12C	hsa-miR-6501-5p	80.8626	NM_033390
ZC3H12C	hsa-miR-2116-5p	80.8596	NM_033390
ZC3H12C	hsa-miR-7705	80.8385	NM_033390
ZC3H12C	hsa-miR-6732-3p	80.719	NM_033390
ZC3H12C	hsa-miR-4310	80.6553	NM_033390

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Motifs and transcription factors (TFs) regulating ZC3H12C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3H12C	metacluster_135.11	NR2C2 (directAnnotation).
ZC3H12C	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZC3H12C	tfdimers__MD00038	TFAP2C (directAnnotation).
ZC3H12C	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZC3H12C	metacluster_7.13	ZFX (directAnnotation).
ZC3H12C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZC3H12C	cisbp__M00968	MTF2 (directAnnotation).
ZC3H12C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZC3H12C	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZC3H12C	cisbp__M00341	PAX6 (directAnnotation).
ZC3H12C	metacluster_198.3	ZFP64 (directAnnotation).
ZC3H12C	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZC3H12C	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZC3H12C	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZC3H12C	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZC3H12C	cisbp__M00788	ZFY (inferredBy_Orthology).
ZC3H12C	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZC3H12C	metacluster_175.1	ZNF283 (directAnnotation).
ZC3H12C	hdpi__ZNF304	ZNF304 (directAnnotation).
ZC3H12C	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZC3H12C	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZC3H12C	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZC3H12C	transfac_pro__M01199	TRIM28 (directAnnotation).
ZC3H12C	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZC3H12C	metacluster_151.2	ZNF23 (directAnnotation).
ZC3H12C	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZC3H12C	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZC3H12C	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZC3H12C	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."