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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TNPO1

Summary for TNPO1

Gene information	Gene symbol	TNPO1
	Ensembl ID	ENSG00000083312
	Entrez ID	3842
	Gene name	transportin 1
	Synonyms	IPO2\|KPNB2\|MIP\|MIP1\|TRN
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TNPO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.442019	1.45e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.369266	1.35e-28
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.26476	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.253923	5.73e-40
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.283072	1.45e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.630577	0.00e+00

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Expression of TNPO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNPO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNPO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNPO1	hsa-miR-646	91.3167	NM_002270
TNPO1	hsa-miR-3692-3p	91.231	NM_153188
TNPO1	hsa-miR-139-5p	91.2133	NM_153188
TNPO1	hsa-miR-203a-3p	91.1829	NM_153188
TNPO1	hsa-miR-3942-5p	90.906	NM_002270
TNPO1	hsa-miR-3606-3p	90.728	NM_002270
TNPO1	hsa-miR-10527-5p	90.6903	NM_002270
TNPO1	hsa-miR-4533	90.5924	NM_153188
TNPO1	hsa-miR-4310	90.5892	NM_002270
TNPO1	hsa-miR-26b-5p	90.4331	NM_002270
TNPO1	hsa-miR-26a-5p	90.4331	NM_002270
TNPO1	hsa-miR-3910	90.0759	NM_002270
TNPO1	hsa-miR-4519	90.0039	NM_002270
TNPO1	hsa-miR-548x-3p	89.9487	NM_153188
TNPO1	hsa-miR-548aj-3p	89.9487	NM_153188
TNPO1	hsa-miR-6794-3p	89.8309	NM_002270
TNPO1	hsa-miR-548aq-3p	89.4803	NM_153188
TNPO1	hsa-miR-548ae-3p	89.4803	NM_153188
TNPO1	hsa-miR-380-3p	89.4772	NM_002270
TNPO1	hsa-miR-4324	89.2633	NM_002270
TNPO1	hsa-miR-4465	89.1391	NM_002270
TNPO1	hsa-miR-4775	89.015	NM_153188
TNPO1	hsa-miR-5695	88.9315	NM_002270
TNPO1	hsa-miR-3908	88.6567	NM_002270
TNPO1	hsa-miR-32-5p	88.6496	NM_002270
TNPO1	hsa-miR-92a-3p	88.6496	NM_002270
TNPO1	hsa-miR-92b-3p	88.6496	NM_002270
TNPO1	hsa-miR-590-3p	88.6286	NM_153188
TNPO1	hsa-miR-4668-5p	88.3072	NM_153188
TNPO1	hsa-miR-6074	88.2434	NM_002270
TNPO1	hsa-miR-136-5p	88.1968	NM_002270
TNPO1	hsa-miR-6508-5p	87.9041	NM_002270
TNPO1	hsa-miR-205-5p	87.895	NM_002270
TNPO1	hsa-miR-4709-3p	87.8934	NM_153188
TNPO1	hsa-miR-548ah-3p	87.6117	NM_153188
TNPO1	hsa-miR-548am-3p	87.6117	NM_153188
TNPO1	hsa-miR-548j-3p	87.6117	NM_153188
TNPO1	hsa-miR-1323	87.4727	NM_153188
TNPO1	hsa-miR-6757-3p	87.2995	NM_002270
TNPO1	hsa-miR-5195-5p	87.2673	NM_002270
TNPO1	hsa-miR-3922-5p	87.2581	NM_002270
TNPO1	hsa-miR-6513-3p	87.1464	NM_002270
TNPO1	hsa-miR-4729	87.0002	NM_153188
TNPO1	hsa-miR-155-3p	86.9723	NM_153188
TNPO1	hsa-miR-4530	86.9709	NM_002270
TNPO1	hsa-miR-548m	86.8626	NM_002270
TNPO1	hsa-miR-1288-5p	86.8273	NM_153188
TNPO1	hsa-miR-8067	86.8005	NM_002270
TNPO1	hsa-miR-4325	86.7711	NM_002270
TNPO1	hsa-miR-3140-5p	86.6611	NM_002270

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Motifs and transcription factors (TFs) regulating TNPO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNPO1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TNPO1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TNPO1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TNPO1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TNPO1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TNPO1	transfac_pro__M04950	EGR1 (directAnnotation).
TNPO1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TNPO1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TNPO1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TNPO1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
TNPO1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
TNPO1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TNPO1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TNPO1	transfac_pro__M00652	NRF1 (directAnnotation).
TNPO1	hdpi__ETV4	ETV4 (directAnnotation).
TNPO1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TNPO1	transfac_pro__M04866	HDAC2 (directAnnotation).
TNPO1	jaspar__MA1122.1	TFDP1 (directAnnotation).
TNPO1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TNPO1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TNPO1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TNPO1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
TNPO1	metacluster_135.11	NR2C2 (directAnnotation).
TNPO1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TNPO1	tfdimers__MD00038	TFAP2C (directAnnotation).
TNPO1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TNPO1	metacluster_7.13	ZFX (directAnnotation).
TNPO1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TNPO1	cisbp__M00968	MTF2 (directAnnotation).
TNPO1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TNPO1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TNPO1	cisbp__M00341	PAX6 (directAnnotation).
TNPO1	metacluster_198.3	ZFP64 (directAnnotation).
TNPO1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TNPO1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TNPO1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TNPO1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TNPO1	cisbp__M00788	ZFY (inferredBy_Orthology).
TNPO1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TNPO1	metacluster_175.1	ZNF283 (directAnnotation).
TNPO1	hdpi__ZNF304	ZNF304 (directAnnotation).
TNPO1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TNPO1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TNPO1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TNPO1	transfac_pro__M01199	TRIM28 (directAnnotation).
TNPO1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TNPO1	metacluster_151.2	ZNF23 (directAnnotation).
TNPO1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TNPO1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TNPO1	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."