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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TEAD1

Summary for TEAD1

Gene information	Gene symbol	TEAD1
	Ensembl ID	ENSG00000187079
	Entrez ID	7003
	Gene name	TEA domain transcription factor 1
	Synonyms	AA\|TCF13\|TEF-1
	Gene type	protein_coding
	UniProtAcc	P28347

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Dataset with differentially expressed gene: TEAD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.778696	5.06e-04
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.38664	2.57e-28
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.315573	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.419052	1.63e-38
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.391831	0.00e+00

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Expression of TEAD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TEAD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TEAD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TEAD1	hsa-miR-5586-3p	85.9284	NM_021961
TEAD1	hsa-miR-302f	85.5578	NM_021961
TEAD1	hsa-miR-6715b-5p	85.4245	NM_021961
TEAD1	hsa-miR-4269	85.4245	NM_021961
TEAD1	hsa-miR-302c-5p	85.3834	NM_021961
TEAD1	hsa-miR-4311	85.1888	NM_021961
TEAD1	hsa-miR-223-5p	85.1799	NM_021961
TEAD1	hsa-miR-320e	85.1426	NM_021961
TEAD1	hsa-miR-330-3p	85.0143	NM_021961
TEAD1	hsa-miR-1205	84.8361	NM_021961
TEAD1	hsa-miR-10394-5p	84.8361	NM_021961
TEAD1	hsa-miR-3119	84.7378	NM_021961
TEAD1	hsa-miR-548ax	84.4058	NM_021961
TEAD1	hsa-miR-548ao-5p	84.4058	NM_021961
TEAD1	hsa-miR-4753-3p	84.2381	NM_021961
TEAD1	hsa-miR-3184-3p	84.1997	NM_021961
TEAD1	hsa-miR-4700-5p	84.1769	NM_021961
TEAD1	hsa-miR-5187-5p	83.9933	NM_021961
TEAD1	hsa-miR-3679-5p	83.8009	NM_021961
TEAD1	hsa-miR-3940-5p	83.785	NM_021961
TEAD1	hsa-miR-4507	83.785	NM_021961
TEAD1	hsa-miR-4666a-3p	83.5416	NM_021961
TEAD1	hsa-miR-138-5p	83.0679	NM_021961
TEAD1	hsa-miR-3192-5p	82.9835	NM_021961
TEAD1	hsa-miR-3185	82.9727	NM_021961
TEAD1	hsa-miR-6848-3p	82.8337	NM_021961
TEAD1	hsa-miR-6843-3p	82.8337	NM_021961
TEAD1	hsa-miR-1185-5p	82.7888	NM_021961
TEAD1	hsa-miR-548ar-3p	82.7386	NM_021961
TEAD1	hsa-miR-4747-5p	82.528	NM_021961
TEAD1	hsa-miR-5196-5p	82.528	NM_021961
TEAD1	hsa-miR-6768-3p	82.3254	NM_021961
TEAD1	hsa-miR-30d-3p	82.166	NM_021961
TEAD1	hsa-miR-30a-3p	82.166	NM_021961
TEAD1	hsa-miR-30e-3p	82.166	NM_021961
TEAD1	hsa-miR-3065-3p	82.0763	NM_021961
TEAD1	hsa-miR-10523-5p	81.9601	NM_021961
TEAD1	hsa-miR-4306	81.882	NM_021961
TEAD1	hsa-miR-6738-3p	81.808	NM_021961
TEAD1	hsa-miR-16-1-3p	81.565	NM_021961
TEAD1	hsa-miR-4276	81.3151	NM_021961
TEAD1	hsa-miR-4667-5p	81.1331	NM_021961
TEAD1	hsa-miR-8089	81.1331	NM_021961
TEAD1	hsa-miR-4288	81.0924	NM_021961
TEAD1	hsa-miR-574-5p	80.8443	NM_021961
TEAD1	hsa-miR-1294	80.6411	NM_021961
TEAD1	hsa-miR-9986	80.6411	NM_021961
TEAD1	hsa-miR-939-5p	80.5732	NM_021961
TEAD1	hsa-miR-1343-5p	80.5732	NM_021961
TEAD1	hsa-miR-548bc	80.5681	NM_021961

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Motifs and transcription factors (TFs) regulating TEAD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TEAD1	metacluster_7.13	ZFX (directAnnotation).
TEAD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TEAD1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TEAD1	jaspar__MA1483.2	ELF2 (directAnnotation).
TEAD1	metacluster_151.2	ZNF23 (directAnnotation).
TEAD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TEAD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TEAD1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TEAD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TEAD1	metacluster_182.10	ZFX (directAnnotation).
TEAD1	hdpi__ETV4	ETV4 (directAnnotation).
TEAD1	transfac_pro__M06071	ZNF814 (directAnnotation).
TEAD1	transfac_pro__M05628	ZNF735 (directAnnotation).
TEAD1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
TEAD1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TEAD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TEAD1	jaspar__MA0079.5	SP1 (directAnnotation).
TEAD1	transfac_pro__M03813	POU3F3 (directAnnotation).
TEAD1	hdpi__ZNF193	ZSCAN9 (directAnnotation).
TEAD1	hdpi__FOXM1	FOXM1 (directAnnotation).
TEAD1	metacluster_135.11	NR2C2 (directAnnotation).
TEAD1	tfdimers__MD00038	TFAP2C (directAnnotation).
TEAD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TEAD1	cisbp__M00968	MTF2 (directAnnotation).
TEAD1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TEAD1	cisbp__M00341	PAX6 (directAnnotation).
TEAD1	metacluster_198.3	ZFP64 (directAnnotation).
TEAD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TEAD1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TEAD1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TEAD1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TEAD1	cisbp__M00788	ZFY (inferredBy_Orthology).
TEAD1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TEAD1	metacluster_175.1	ZNF283 (directAnnotation).
TEAD1	hdpi__ZNF304	ZNF304 (directAnnotation).
TEAD1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TEAD1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TEAD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TEAD1	transfac_pro__M01199	TRIM28 (directAnnotation).
TEAD1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TEAD1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TEAD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TEAD1	transfac_pro__M03806	ZBTB7C (directAnnotation).
TEAD1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TEAD1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
TEAD1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
TEAD1	transfac_pro__M01253	CNOT3 (directAnnotation).
TEAD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
TEAD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TEAD1	transfac_pro__M05712	ZNF134 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."