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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TAOK1

Summary for TAOK1

Gene information	Gene symbol	TAOK1
	Ensembl ID	ENSG00000160551
	Entrez ID	57551
	Gene name	TAO kinase 1
	Synonyms	FLJ14314\|hKFC-B\|hTAOK1\|KIAA1361\|MAP3K16\|MARKK\|PSK2\|TAO1
	Gene type	protein_coding
	UniProtAcc	Q7L7X3

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Dataset with differentially expressed gene: TAOK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.16865	9.23e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.260714	4.53e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.376942	1.69e-19

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Expression of TAOK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAOK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAOK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAOK1	hsa-miR-1297	90.1316	NM_020791
TAOK1	hsa-miR-548ar-3p	90.0868	NM_025142
TAOK1	hsa-miR-3133	89.932	NM_025142
TAOK1	hsa-miR-4282	89.7395	NM_025142
TAOK1	hsa-miR-485-5p	89.6141	NM_025142
TAOK1	hsa-miR-6884-5p	89.6141	NM_025142
TAOK1	hsa-miR-664b-3p	89.4661	NM_020791
TAOK1	hsa-miR-579-3p	89.4661	NM_020791
TAOK1	hsa-miR-3662	89.3429	NM_025142
TAOK1	hsa-miR-623	89.2592	NM_020791
TAOK1	hsa-miR-193a-3p	89.2429	NM_020791
TAOK1	hsa-miR-193b-3p	89.2429	NM_020791
TAOK1	hsa-miR-216b-3p	89.2168	NM_025142
TAOK1	hsa-miR-133b	89.2015	NM_020791
TAOK1	hsa-miR-133a-3p	89.2015	NM_020791
TAOK1	hsa-miR-3619-3p	89.1961	NM_025142
TAOK1	hsa-miR-10398-5p	88.3595	NM_020791
TAOK1	hsa-miR-548f-3p	88.2203	NM_025142
TAOK1	hsa-miR-548a-3p	88.2203	NM_025142
TAOK1	hsa-miR-548e-3p	88.2203	NM_025142
TAOK1	hsa-miR-548az-3p	88.2203	NM_025142
TAOK1	hsa-miR-548bc	88.2203	NM_025142
TAOK1	hsa-let-7g-3p	88.1925	NM_020791
TAOK1	hsa-let-7a-2-3p	88.1925	NM_020791
TAOK1	hsa-miR-4262	88.0624	NM_020791
TAOK1	hsa-miR-3938	87.9406	NM_020791
TAOK1	hsa-miR-518c-5p	87.9203	NM_020791
TAOK1	hsa-miR-4729	87.8391	NM_025142
TAOK1	hsa-miR-570-3p	87.8147	NM_025142
TAOK1	hsa-miR-4446-5p	87.7772	NM_020791
TAOK1	hsa-miR-569	87.7096	NM_020791
TAOK1	hsa-miR-4789-5p	87.68	NM_020791
TAOK1	hsa-miR-3619-5p	87.5932	NM_020791
TAOK1	hsa-miR-7-2-3p	87.584	NM_025142
TAOK1	hsa-miR-7-1-3p	87.584	NM_025142
TAOK1	hsa-miR-4803	87.4258	NM_025142
TAOK1	hsa-miR-5580-3p	87.3071	NM_025142
TAOK1	hsa-miR-1227-3p	87.2576	NM_020791
TAOK1	hsa-miR-6513-5p	86.9967	NM_025142
TAOK1	hsa-miR-548n	86.8603	NM_020791
TAOK1	hsa-miR-26b-5p	86.5554	NM_020791
TAOK1	hsa-miR-26a-5p	86.5554	NM_020791
TAOK1	hsa-miR-7849-3p	86.224	NM_020791
TAOK1	hsa-miR-214-3p	86.0394	NM_020791
TAOK1	hsa-miR-761	86.0394	NM_020791
TAOK1	hsa-miR-4710	85.8131	NM_025142
TAOK1	hsa-miR-3120-3p	85.6129	NM_020791
TAOK1	hsa-miR-4732-3p	85.609	NM_020791
TAOK1	hsa-miR-490-5p	85.4857	NM_025142
TAOK1	hsa-miR-624-5p	84.9844	NM_020791

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Motifs and transcription factors (TFs) regulating TAOK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAOK1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TAOK1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TAOK1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TAOK1	transfac_pro__M04617	ZBTB7A (directAnnotation).
TAOK1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TAOK1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TAOK1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TAOK1	transfac_pro__M07387	ZBTB7A (directAnnotation).
TAOK1	transfac_pro__M07436	WT1 (directAnnotation).
TAOK1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TAOK1	transfac_pro__M00716	ZBTB14 (directAnnotation).
TAOK1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TAOK1	hdpi__HIP2	UBE2K (directAnnotation).
TAOK1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TAOK1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TAOK1	transfac_pro__M04893	TAF1 (directAnnotation).
TAOK1	transfac_pro__M03876	ZBTB33 (directAnnotation).
TAOK1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TAOK1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TAOK1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TAOK1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TAOK1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TAOK1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TAOK1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TAOK1	metacluster_7.13	ZFX (directAnnotation).
TAOK1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TAOK1	cisbp__M00968	MTF2 (directAnnotation).
TAOK1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TAOK1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TAOK1	cisbp__M00341	PAX6 (directAnnotation).
TAOK1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TAOK1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TAOK1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TAOK1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TAOK1	cisbp__M00788	ZFY (inferredBy_Orthology).
TAOK1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TAOK1	metacluster_175.1	ZNF283 (directAnnotation).
TAOK1	hdpi__ZNF304	ZNF304 (directAnnotation).
TAOK1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TAOK1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TAOK1	transfac_pro__M01199	TRIM28 (directAnnotation).
TAOK1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TAOK1	metacluster_151.2	ZNF23 (directAnnotation).
TAOK1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TAOK1	transfac_pro__M03806	ZBTB7C (directAnnotation).
TAOK1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TAOK1	jaspar__MA0079.5	SP1 (directAnnotation).
TAOK1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
TAOK1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
TAOK1	transfac_pro__M01253	CNOT3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TAOK1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."