Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC7A11

Summary for SLC7A11

Gene information	Gene symbol	SLC7A11
	Ensembl ID	ENSG00000151012
	Entrez ID	23657
	Gene name	solute carrier family 7 member 11
	Synonyms	xCT
	Gene type	protein_coding
	UniProtAcc	Q9UPY5

Top

Dataset with differentially expressed gene: SLC7A11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.864886	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.482195	3.74e-02
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.08479	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.295431	3.04e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.509912	1.03e-28
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.60725	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.805933	0.00e+00

Top

Expression of SLC7A11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SLC7A11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SLC7A11	Irregularity in Drug Uptake and Drug Efflux

Page: 1

Top

MicroRNAs (miRNA) regulating SLC7A11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC7A11	hsa-miR-142-5p	84.1319	NM_014331
SLC7A11	hsa-miR-335-3p	84.1293	NM_014331
SLC7A11	hsa-miR-570-3p	84.0919	NM_014331
SLC7A11	hsa-miR-380-3p	84.0206	NM_014331
SLC7A11	hsa-miR-6778-3p	83.7278	NM_014331
SLC7A11	hsa-miR-1277-5p	83.7125	NM_014331
SLC7A11	hsa-miR-489-3p	83.6181	NM_014331
SLC7A11	hsa-miR-188-3p	83.324	NM_014331
SLC7A11	hsa-miR-5697	83.2909	NM_014331
SLC7A11	hsa-miR-3915	83.1968	NM_014331
SLC7A11	hsa-miR-125b-2-3p	83.1584	NM_014331
SLC7A11	hsa-miR-6719-3p	83.1227	NM_014331
SLC7A11	hsa-miR-6083	83.0928	NM_014331
SLC7A11	hsa-miR-3149	82.8227	NM_014331
SLC7A11	hsa-miR-7853-5p	82.5579	NM_014331
SLC7A11	hsa-miR-105-5p	82.5579	NM_014331
SLC7A11	hsa-miR-606	82.4403	NM_014331
SLC7A11	hsa-miR-4729	82.3753	NM_014331
SLC7A11	hsa-miR-12124	81.8392	NM_014331
SLC7A11	hsa-miR-4666b	81.824	NM_014331
SLC7A11	hsa-miR-4264	81.7956	NM_014331
SLC7A11	hsa-miR-6501-3p	80.6637	NM_014331
SLC7A11	hsa-miR-548as-3p	80.4732	NM_014331
SLC7A11	hsa-miR-6504-3p	80.3181	NM_014331
SLC7A11	hsa-miR-4770	80.2514	NM_014331
SLC7A11	hsa-miR-143-3p	80.2514	NM_014331
SLC7A11	hsa-miR-203a-3p	80.1493	NM_014331
SLC7A11	hsa-miR-664b-3p	80.0378	NM_014331
SLC7A11	hsa-miR-579-3p	80.0378	NM_014331

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating SLC7A11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC7A11	metacluster_22.11	NFE2 (directAnnotation).
SLC7A11	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
SLC7A11	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SLC7A11	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SLC7A11	metacluster_22.17	NFE2 (directAnnotation).
SLC7A11	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
SLC7A11	transfac_pro__M05395	ZNF276 (inferredBy_Orthology).
SLC7A11	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SLC7A11	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SLC7A11	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
SLC7A11	transfac_pro__M05590	ZNF772 (directAnnotation).
SLC7A11	metacluster_68.7	MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY (directAnnotation). MEIS1; MEIS1; MEIS1; MEIS1; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; MEIS3; PBX1; PBX1; PBX1; PBX2; PBX2; PBX2; PBX3; PBX3; PBX3; PBX4; PBX4; PBX4; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY; TGIF2LY (inferredBy_Orthology).
SLC7A11	transfac_pro__M04840	MEF2C (directAnnotation).
SLC7A11	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
SLC7A11	transfac_pro__M06667	ZNF599 (directAnnotation).
SLC7A11	transfac_pro__M06025	ZNF195 (directAnnotation).
SLC7A11	transfac_pro__M05852	ZNF689 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC7A11	"Acetylcysteine"	DB06151	small molecule
SLC7A11	"Cystine"	DB00138	small molecule
SLC7A11	"Glutamic acid"	DB00142	small molecule
SLC7A11	"Riluzole"	DB00740	small molecule
SLC7A11	"Sulfasalazine"	DB00795	small molecule
SLC7A11	"Thimerosal"	DB11590	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."