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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3PXD2A

Summary for SH3PXD2A

Gene information	Gene symbol	SH3PXD2A
	Ensembl ID	ENSG00000107957
	Entrez ID	9644
	Gene name	SH3 and PX domains 2A
	Synonyms	FISH\|KIAA0418\|SH3MD1
	Gene type	protein_coding
	UniProtAcc	Q5TCZ1

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Dataset with differentially expressed gene: SH3PXD2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.262626	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.339695	0.00e+00

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Expression of SH3PXD2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3PXD2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3PXD2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3PXD2A	hsa-miR-3173-5p	85.8977	NM_014631
SH3PXD2A	hsa-miR-1278	85.693	NM_014631
SH3PXD2A	hsa-miR-3192-5p	85.6465	NM_014631
SH3PXD2A	hsa-miR-661	85.6133	NM_014631
SH3PXD2A	hsa-miR-3120-3p	85.5112	NM_014631
SH3PXD2A	hsa-miR-4719	85.501	NM_014631
SH3PXD2A	hsa-miR-6895-3p	85.3834	NM_014631
SH3PXD2A	hsa-miR-3166	85.3542	NM_014631
SH3PXD2A	hsa-miR-4505	85.2037	NM_014631
SH3PXD2A	hsa-miR-5787	85.1556	NM_014631
SH3PXD2A	hsa-miR-1291	85.1397	NM_014631
SH3PXD2A	hsa-miR-500b-3p	85.0862	NM_014631
SH3PXD2A	hsa-miR-8073	85.0252	NM_014631
SH3PXD2A	hsa-miR-221-5p	85.0252	NM_014631
SH3PXD2A	hsa-miR-5581-5p	84.8724	NM_014631
SH3PXD2A	hsa-miR-6792-3p	84.8188	NM_014631
SH3PXD2A	hsa-miR-4447	84.7286	NM_014631
SH3PXD2A	hsa-miR-7152-5p	84.6755	NM_014631
SH3PXD2A	hsa-miR-4261	84.1992	NM_014631
SH3PXD2A	hsa-miR-4691-5p	84.1857	NM_014631
SH3PXD2A	hsa-miR-12125	84.1228	NM_014631
SH3PXD2A	hsa-miR-365b-3p	84.081	NM_014631
SH3PXD2A	hsa-miR-365a-3p	84.081	NM_014631
SH3PXD2A	hsa-miR-1249-5p	84.0499	NM_014631
SH3PXD2A	hsa-miR-6797-5p	84.0499	NM_014631
SH3PXD2A	hsa-miR-93-3p	84.0153	NM_014631
SH3PXD2A	hsa-miR-2276-5p	83.8445	NM_014631
SH3PXD2A	hsa-miR-6721-5p	83.8165	NM_014631
SH3PXD2A	hsa-miR-584-5p	83.7463	NM_014631
SH3PXD2A	hsa-miR-3163	83.5377	NM_014631
SH3PXD2A	hsa-miR-4465	83.5095	NM_014631
SH3PXD2A	hsa-miR-20a-3p	83.4795	NM_014631
SH3PXD2A	hsa-miR-7155-3p	83.4364	NM_014631
SH3PXD2A	hsa-miR-3136-3p	83.4364	NM_014631
SH3PXD2A	hsa-miR-143-3p	83.4206	NM_014631
SH3PXD2A	hsa-miR-4770	83.4206	NM_014631
SH3PXD2A	hsa-miR-26b-5p	83.166	NM_014631
SH3PXD2A	hsa-miR-26a-5p	83.166	NM_014631
SH3PXD2A	hsa-miR-4520-2-3p	82.9217	NM_014631
SH3PXD2A	hsa-miR-6775-3p	82.6722	NM_014631
SH3PXD2A	hsa-miR-6870-5p	82.6323	NM_014631
SH3PXD2A	hsa-miR-101-3p	82.554	NM_014631
SH3PXD2A	hsa-miR-5688	82.5535	NM_014631
SH3PXD2A	hsa-miR-495-3p	82.5535	NM_014631
SH3PXD2A	hsa-miR-766-3p	82.2548	NM_014631
SH3PXD2A	hsa-miR-6819-5p	82.0724	NM_014631
SH3PXD2A	hsa-miR-4495	81.8853	NM_014631
SH3PXD2A	hsa-miR-6812-5p	81.6949	NM_014631
SH3PXD2A	hsa-miR-6748-3p	81.5857	NM_014631
SH3PXD2A	hsa-miR-6852-5p	81.5338	NM_014631

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Motifs and transcription factors (TFs) regulating SH3PXD2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3PXD2A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SH3PXD2A	transfac_pro__M02281	SP1 (directAnnotation).
SH3PXD2A	transfac_pro__M06213	ZNF267 (directAnnotation).
SH3PXD2A	transfac_pro__M06035	ZNF749 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."