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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SESTD1

Summary for SESTD1

Gene information	Gene symbol	SESTD1
	Ensembl ID	ENSG00000187231
	Entrez ID	91404
	Gene name	SEC14 and spectrin domain containing 1
	Synonyms	DKFZp434O0515\|Solo
	Gene type	protein_coding
	UniProtAcc	Q86VW0

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Dataset with differentially expressed gene: SESTD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.406392	0.00e+00

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Expression of SESTD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SESTD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SESTD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SESTD1	hsa-miR-585-5p	84.7875	NM_178123
SESTD1	hsa-miR-664a-3p	84.521	NM_178123
SESTD1	hsa-miR-4699-3p	84.1144	NM_178123
SESTD1	hsa-miR-668-3p	83.3637	NM_178123
SESTD1	hsa-miR-3976	83.3442	NM_178123
SESTD1	hsa-miR-222-5p	83.2957	NM_178123
SESTD1	hsa-miR-3163	83.244	NM_178123
SESTD1	hsa-miR-3185	83.235	NM_178123
SESTD1	hsa-miR-1248	83.0944	NM_178123
SESTD1	hsa-let-7a-5p	82.9052	NM_178123
SESTD1	hsa-let-7f-5p	82.9052	NM_178123
SESTD1	hsa-let-7e-5p	82.9052	NM_178123
SESTD1	hsa-miR-98-5p	82.9052	NM_178123
SESTD1	hsa-let-7i-5p	82.9052	NM_178123
SESTD1	hsa-let-7c-5p	82.9052	NM_178123
SESTD1	hsa-let-7g-5p	82.9052	NM_178123
SESTD1	hsa-let-7b-5p	82.9052	NM_178123
SESTD1	hsa-miR-153-3p	82.4134	NM_178123
SESTD1	hsa-miR-890	82.3531	NM_178123
SESTD1	hsa-miR-4680-5p	81.6272	NM_178123
SESTD1	hsa-miR-7843-3p	81.5463	NM_178123
SESTD1	hsa-miR-150-5p	81.353	NM_178123
SESTD1	hsa-miR-205-3p	81.1798	NM_178123
SESTD1	hsa-miR-6867-3p	81.0745	NM_178123
SESTD1	hsa-miR-454-3p	81.0338	NM_178123
SESTD1	hsa-miR-129-1-3p	80.9289	NM_178123
SESTD1	hsa-miR-129-2-3p	80.9289	NM_178123
SESTD1	hsa-miR-580-3p	80.726	NM_178123
SESTD1	hsa-miR-15b-5p	80.6417	NM_178123
SESTD1	hsa-miR-15a-5p	80.6417	NM_178123
SESTD1	hsa-miR-16-5p	80.6417	NM_178123
SESTD1	hsa-miR-195-5p	80.6417	NM_178123
SESTD1	hsa-miR-6124	80.3841	NM_178123
SESTD1	hsa-miR-3914	80.2275	NM_178123

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Motifs and transcription factors (TFs) regulating SESTD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SESTD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SESTD1	transfac_pro__M04950	EGR1 (directAnnotation).
SESTD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SESTD1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SESTD1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SESTD1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
SESTD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SESTD1	transfac_pro__M00652	NRF1 (directAnnotation).
SESTD1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SESTD1	transfac_pro__M04866	HDAC2 (directAnnotation).
SESTD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SESTD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SESTD1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."