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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SAMD8

Summary for SAMD8

Gene information	Gene symbol	SAMD8
	Ensembl ID	ENSG00000156671
	Entrez ID	142891
	Gene name	sterile alpha motif domain containing 8
	Synonyms	FLJ25082\|SMSr
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SAMD8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.544565	0.00e+00

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Expression of SAMD8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SAMD8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SAMD8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SAMD8	hsa-miR-4699-3p	86.3046	NM_144660
SAMD8	hsa-miR-4775	86.029	NM_001174156
SAMD8	hsa-miR-22-5p	85.8624	NM_001174156
SAMD8	hsa-miR-499a-5p	85.828	NM_001174156
SAMD8	hsa-miR-3646	85.6778	NM_001174156
SAMD8	hsa-miR-4778-3p	85.6674	NM_001174156
SAMD8	hsa-miR-3194-3p	85.3436	NM_144660
SAMD8	hsa-miR-4495	84.7349	NM_144660
SAMD8	hsa-miR-548at-5p	84.2818	NM_001174156
SAMD8	hsa-miR-548k	84.2717	NM_144660
SAMD8	hsa-miR-8054	84.2717	NM_144660
SAMD8	hsa-miR-548av-5p	84.2717	NM_144660
SAMD8	hsa-miR-6773-3p	84.159	NM_001174156
SAMD8	hsa-miR-7151-3p	83.7358	NM_001174156
SAMD8	hsa-miR-548e-3p	83.698	NM_001174156
SAMD8	hsa-miR-548f-3p	83.698	NM_001174156
SAMD8	hsa-miR-548bc	83.698	NM_001174156
SAMD8	hsa-miR-548az-3p	83.698	NM_001174156
SAMD8	hsa-miR-548a-3p	83.698	NM_001174156
SAMD8	hsa-miR-26b-5p	83.6643	NM_001174156
SAMD8	hsa-miR-26a-5p	83.6643	NM_001174156
SAMD8	hsa-miR-4422	83.512	NM_001174156
SAMD8	hsa-miR-135b-5p	83.46	NM_144660
SAMD8	hsa-miR-135a-5p	83.46	NM_144660
SAMD8	hsa-miR-4760-3p	83.1175	NM_001174156
SAMD8	hsa-miR-20a-5p	83.0831	NM_144660
SAMD8	hsa-miR-106b-5p	83.0831	NM_144660
SAMD8	hsa-miR-4756-3p	82.9481	NM_001174156
SAMD8	hsa-miR-130b-5p	82.3309	NM_001174156
SAMD8	hsa-miR-19a-3p	82.0101	NM_144660
SAMD8	hsa-miR-19b-3p	82.0101	NM_144660
SAMD8	hsa-miR-33a-3p	81.6569	NM_144660
SAMD8	hsa-miR-5002-3p	81.5977	NM_001174156
SAMD8	hsa-miR-548ar-3p	81.4191	NM_001174156
SAMD8	hsa-miR-4659a-3p	81.3651	NM_144660
SAMD8	hsa-miR-4659b-3p	81.3651	NM_144660
SAMD8	hsa-miR-6747-3p	81.1338	NM_001174156
SAMD8	hsa-miR-106a-5p	81.1162	NM_144660
SAMD8	hsa-miR-526b-3p	81.1162	NM_144660
SAMD8	hsa-miR-4263	80.9929	NM_001174156
SAMD8	hsa-miR-636	80.4301	NM_144660
SAMD8	hsa-miR-548ao-5p	80.0726	NM_001174156
SAMD8	hsa-miR-548ax	80.0726	NM_001174156
SAMD8	hsa-miR-9-5p	80.0714	NM_144660

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Motifs and transcription factors (TFs) regulating SAMD8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SAMD8	metacluster_135.11	NR2C2 (directAnnotation).
SAMD8	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SAMD8	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SAMD8	metacluster_7.13	ZFX (directAnnotation).
SAMD8	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SAMD8	cisbp__M00968	MTF2 (directAnnotation).
SAMD8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SAMD8	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SAMD8	cisbp__M00341	PAX6 (directAnnotation).
SAMD8	metacluster_198.3	ZFP64 (directAnnotation).
SAMD8	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SAMD8	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SAMD8	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SAMD8	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SAMD8	cisbp__M00788	ZFY (inferredBy_Orthology).
SAMD8	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SAMD8	metacluster_175.1	ZNF283 (directAnnotation).
SAMD8	hdpi__ZNF304	ZNF304 (directAnnotation).
SAMD8	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SAMD8	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SAMD8	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SAMD8	transfac_pro__M01199	TRIM28 (directAnnotation).
SAMD8	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SAMD8	metacluster_151.2	ZNF23 (directAnnotation).
SAMD8	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SAMD8	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SAMD8	transfac_pro__M03806	ZBTB7C (directAnnotation).
SAMD8	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."