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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF38

Summary for RNF38

Gene information	Gene symbol	RNF38
	Ensembl ID	ENSG00000137075
	Entrez ID	152006
	Gene name	ring finger protein 38
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9H0F5

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Dataset with differentially expressed gene: RNF38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of RNF38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF38	hsa-miR-199a-5p	84.1351	NM_022781
RNF38	hsa-miR-199b-5p	84.1351	NM_022781
RNF38	hsa-miR-3928-3p	84.1346	NM_022781
RNF38	hsa-miR-548t-5p	83.8352	NM_022781
RNF38	hsa-miR-548az-5p	83.8352	NM_022781
RNF38	hsa-miR-3609	83.4766	NM_022781
RNF38	hsa-miR-548ah-5p	83.4766	NM_022781
RNF38	hsa-miR-3927-3p	83.4093	NM_022781
RNF38	hsa-miR-6831-5p	83.4093	NM_022781
RNF38	hsa-miR-4668-3p	82.5967	NM_022781
RNF38	hsa-miR-4729	82.4917	NM_022781
RNF38	hsa-miR-603	82.4789	NM_194332
RNF38	hsa-miR-148a-5p	82.3833	NM_194332
RNF38	hsa-miR-6131	82.3623	NM_022781
RNF38	hsa-miR-1-3p	82.331	NM_022781
RNF38	hsa-miR-206	82.331	NM_022781
RNF38	hsa-miR-613	82.331	NM_022781
RNF38	hsa-miR-27b-3p	82.3037	NM_022781
RNF38	hsa-miR-27a-3p	82.3037	NM_022781
RNF38	hsa-miR-9985	82.3037	NM_022781
RNF38	hsa-miR-3177-5p	81.8217	NM_022781
RNF38	hsa-miR-23a-3p	81.8124	NM_022781
RNF38	hsa-miR-23b-3p	81.8124	NM_022781
RNF38	hsa-miR-23c	81.8124	NM_022781
RNF38	hsa-miR-3145-3p	81.7713	NM_022781
RNF38	hsa-miR-101-3p	81.6669	NM_194332
RNF38	hsa-miR-6509-3p	81.5508	NM_022781
RNF38	hsa-miR-369-3p	81.2595	NM_194332
RNF38	hsa-miR-8077	81.2274	NM_022781
RNF38	hsa-miR-3658	81.0747	NM_022781
RNF38	hsa-miR-548ag	80.8431	NM_022781
RNF38	hsa-miR-548ai	80.8431	NM_022781
RNF38	hsa-miR-548ba	80.8431	NM_022781
RNF38	hsa-miR-570-5p	80.8431	NM_022781
RNF38	hsa-miR-548t-3p	80.4235	NM_194332
RNF38	hsa-miR-548ap-3p	80.4235	NM_194332
RNF38	hsa-miR-548aa	80.4235	NM_194332
RNF38	hsa-miR-4492	80.4108	NM_194332
RNF38	hsa-miR-138-5p	80.4035	NM_022781

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Motifs and transcription factors (TFs) regulating RNF38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF38	taipale_tf_pairs__ETV2_EOMES_NGGTGTNNNNNNNNNNNNNNNCCGGAWNNN_CAP_repr	EOMES; ETV2 (directAnnotation).
RNF38	taipale_tf_pairs__ELK1_EOMES_RGGTGNGANNNNNNNNTNNCACCGGAAGY_CAP	ELK1; EOMES (directAnnotation).
RNF38	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
RNF38	swissregulon__hs__MYB	MYB (directAnnotation).
RNF38	transfac_pro__M04944	GABPA (directAnnotation).
RNF38	transfac_pro__M05655	ZNF705G (directAnnotation).
RNF38	nitta__sens_TATGCT40NACT_KAA_AATAAATCACTGCA_m1_c3	GFI1 (inferredBy_Orthology).
RNF38	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
RNF38	transfac_pro__M07474	TBX20 (directAnnotation).
RNF38	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
RNF38	transfac_pro__M06332	ZNF585A (directAnnotation).
RNF38	transfac_pro__M06905	ZNF585B (directAnnotation).
RNF38	transfac_pro__M05883	ZNF709 (directAnnotation).
RNF38	transfac_pro__M05690	ZNF20 (directAnnotation).
RNF38	transfac_pro__M06340	ZNF790 (directAnnotation).
RNF38	transfac_pro__M05617	ZNF500 (directAnnotation).
RNF38	transfac_pro__M06745	ZNF780B (directAnnotation).
RNF38	metacluster_126.11	ZNF286A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."