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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RC3H1

Summary for RC3H1

Gene information	Gene symbol	RC3H1
	Ensembl ID	ENSG00000135870
	Entrez ID	149041
	Gene name	ring finger and CCCH-type domains 1
	Synonyms	KIAA2025\|RNF198\|roquin\|RP5-1198E17.5
	Gene type	protein_coding
	UniProtAcc	Q5TC82

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Dataset with differentially expressed gene: RC3H1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.458907	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261172	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.34269	2.16e-34

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Expression of RC3H1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RC3H1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RC3H1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RC3H1	hsa-miR-5681a	91.5371	NM_001300850
RC3H1	hsa-miR-6757-3p	91.4793	NM_001300850
RC3H1	hsa-miR-6814-5p	91.1582	NM_001300850
RC3H1	hsa-miR-1827	91.1094	NM_001300850
RC3H1	hsa-miR-570-3p	90.9714	NM_001300851
RC3H1	hsa-miR-148b-3p	90.4163	NM_001300850
RC3H1	hsa-miR-152-3p	90.4163	NM_001300850
RC3H1	hsa-miR-148a-3p	90.4163	NM_001300850
RC3H1	hsa-miR-4768-3p	90.4121	NM_001300851
RC3H1	hsa-miR-7110-5p	90.0891	NM_001300851
RC3H1	hsa-miR-6842-5p	90.0891	NM_001300851
RC3H1	hsa-miR-186-5p	90.0828	NM_001300851
RC3H1	hsa-miR-548u	90.053	NM_001300850
RC3H1	hsa-miR-6890-5p	89.9448	NM_001300851
RC3H1	hsa-miR-4680-3p	89.9069	NM_001300851
RC3H1	hsa-miR-7856-5p	89.7218	NM_001300850
RC3H1	hsa-miR-21-3p	89.6703	NM_001300851
RC3H1	hsa-miR-122b-3p	89.6703	NM_001300851
RC3H1	hsa-miR-4303	89.6571	NM_001300851
RC3H1	hsa-miR-381-3p	89.6087	NM_001300851
RC3H1	hsa-miR-300	89.6087	NM_001300851
RC3H1	hsa-miR-7161-5p	89.5326	NM_001300850
RC3H1	hsa-miR-7515	89.0065	NM_001300850
RC3H1	hsa-miR-3671	88.8797	NM_001300851
RC3H1	hsa-miR-3679-3p	88.8039	NM_001300851
RC3H1	hsa-miR-6124	88.655	NM_001300850
RC3H1	hsa-miR-3613-3p	88.6529	NM_001300851
RC3H1	hsa-miR-548e-5p	88.62	NM_001300851
RC3H1	hsa-miR-2115-3p	88.5466	NM_001300850
RC3H1	hsa-miR-150-5p	88.3897	NM_001300850
RC3H1	hsa-miR-3662	88.3558	NM_001300851
RC3H1	hsa-miR-5093	88.3212	NM_001300851
RC3H1	hsa-miR-6753-3p	88.2008	NM_001300851
RC3H1	hsa-miR-7107-3p	88.2008	NM_001300851
RC3H1	hsa-miR-16-2-3p	88.0419	NM_001300851
RC3H1	hsa-miR-195-3p	88.0419	NM_001300851
RC3H1	hsa-miR-3606-5p	87.8148	NM_001300851
RC3H1	hsa-miR-1250-3p	87.5509	NM_001300850
RC3H1	hsa-miR-6752-5p	87.249	NM_001300851
RC3H1	hsa-miR-29a-5p	87.2428	NM_001300851
RC3H1	hsa-miR-9985	87.2372	NM_001300851
RC3H1	hsa-miR-27a-3p	87.2372	NM_001300851
RC3H1	hsa-miR-513a-5p	87.2372	NM_001300851
RC3H1	hsa-miR-27b-3p	87.2372	NM_001300851
RC3H1	hsa-miR-4477a	87.0269	NM_001300851
RC3H1	hsa-miR-5000-5p	86.9435	NM_001300851
RC3H1	hsa-miR-3187-5p	86.9356	NM_001300850
RC3H1	hsa-miR-6860	86.9315	NM_001300850
RC3H1	hsa-miR-5189-5p	86.9315	NM_001300850
RC3H1	hsa-miR-612	86.9315	NM_001300850

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Motifs and transcription factors (TFs) regulating RC3H1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."