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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: QKI

Summary for QKI

Gene information	Gene symbol	QKI
	Ensembl ID	ENSG00000112531
	Entrez ID	9444
	Gene name	QKI, KH domain containing RNA binding
	Synonyms	QK3
	Gene type	protein_coding
	UniProtAcc	Q96PU8

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Dataset with differentially expressed gene: QKI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.884928	3.12e-09
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.527092	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.250091	4.03e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.315184	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.523209	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.303771	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.350074	6.04e-19

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Expression of QKI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to QKI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
QKI	Regulation by the Disease Microenvironment

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MicroRNAs (miRNA) regulating QKI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
QKI	hsa-miR-96-5p	90.4382	NM_206855
QKI	hsa-miR-6513-3p	90.3816	NM_206855
QKI	hsa-miR-670-5p	90.0554	NM_206855
QKI	hsa-miR-548g-3p	90.0046	NM_206854
QKI	hsa-miR-4731-5p	89.9917	NM_206854
QKI	hsa-miR-376b-3p	89.7994	NM_206853
QKI	hsa-miR-376a-3p	89.7994	NM_206853
QKI	hsa-miR-4684-3p	89.4936	NM_206855
QKI	hsa-miR-6074	89.4887	NM_206855
QKI	hsa-miR-6800-5p	89.4466	NM_206853
QKI	hsa-miR-421	89.2198	NM_206855
QKI	hsa-miR-3145-3p	89.195	NM_206855
QKI	hsa-miR-5195-3p	89.1102	NM_206855
QKI	hsa-miR-506-5p	89.0425	NM_206855
QKI	hsa-miR-4276	89.025	NM_206855
QKI	hsa-miR-511-5p	88.9248	NM_206855
QKI	hsa-miR-145-5p	88.9124	NM_206855
QKI	hsa-miR-181c-5p	88.8841	NM_206855
QKI	hsa-miR-181a-5p	88.8841	NM_206855
QKI	hsa-miR-181d-5p	88.8841	NM_206855
QKI	hsa-miR-181b-5p	88.8841	NM_206855
QKI	hsa-miR-532-3p	88.8011	NM_206855
QKI	hsa-miR-186-5p	88.3984	NM_206855
QKI	hsa-miR-1271-5p	88.3743	NM_206855
QKI	hsa-miR-4685-3p	88.3703	NM_206855
QKI	hsa-miR-4287	88.3703	NM_206855
QKI	hsa-miR-2052	88.3225	NM_206855
QKI	hsa-miR-450b-5p	88.2977	NM_206855
QKI	hsa-miR-195-5p	88.263	NM_206855
QKI	hsa-miR-15a-5p	88.263	NM_206855
QKI	hsa-miR-15b-5p	88.263	NM_206855
QKI	hsa-miR-16-5p	88.263	NM_206855
QKI	hsa-miR-9983-3p	88.2089	NM_206853
QKI	hsa-miR-1185-1-3p	88.1925	NM_206855
QKI	hsa-miR-1185-2-3p	88.1925	NM_206855
QKI	hsa-miR-6853-3p	87.9368	NM_206854
QKI	hsa-miR-6838-5p	87.8941	NM_206855
QKI	hsa-miR-497-5p	87.8941	NM_206855
QKI	hsa-miR-424-5p	87.8941	NM_206855
QKI	hsa-let-7f-2-3p	87.8861	NM_206855
QKI	hsa-miR-651-3p	87.5305	NM_206853
QKI	hsa-miR-524-5p	87.4576	NM_206855
QKI	hsa-miR-520d-5p	87.4576	NM_206855
QKI	hsa-miR-129-5p	87.329	NM_206853
QKI	hsa-miR-6766-5p	87.3137	NM_001301085
QKI	hsa-miR-3658	87.226	NM_206853
QKI	hsa-miR-548aw	87.1494	NM_206855
QKI	hsa-miR-579-3p	87.1075	NM_206854
QKI	hsa-miR-664b-3p	87.1075	NM_206854
QKI	hsa-miR-4682	86.909	NM_206855

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Motifs and transcription factors (TFs) regulating QKI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
QKI	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
QKI	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
QKI	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
QKI	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
QKI	transfac_pro__M04617	ZBTB7A (directAnnotation).
QKI	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
QKI	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
QKI	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
QKI	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
QKI	transfac_pro__M07387	ZBTB7A (directAnnotation).
QKI	transfac_pro__M07436	WT1 (directAnnotation).
QKI	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
QKI	transfac_pro__M00716	ZBTB14 (directAnnotation).
QKI	swissregulon__hs__CHD1	CHD1 (directAnnotation).
QKI	hdpi__HIP2	UBE2K (directAnnotation).
QKI	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
QKI	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
QKI	transfac_pro__M04893	TAF1 (directAnnotation).
QKI	transfac_pro__M03876	ZBTB33 (directAnnotation).
QKI	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
QKI	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
QKI	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
QKI	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
QKI	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
QKI	transfac_pro__M04916	TAF1 (directAnnotation).
QKI	metacluster_3.14	WT1; WT1 (directAnnotation).
QKI	hdpi__TFAM	TFAM (directAnnotation).
QKI	transfac_pro__M02089	E2F3 (directAnnotation).
QKI	transfac_pro__M07329	SP7 (directAnnotation).
QKI	transfac_pro__M01122	ZNF219 (directAnnotation).
QKI	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
QKI	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
QKI	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
QKI	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
QKI	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
QKI	transfac_pro__M08819	KLF2 (directAnnotation).
QKI	transfac_pro__M01175	ZBTB7B (directAnnotation).
QKI	cisbp__M00249	WT1 (directAnnotation).
QKI	transfac_pro__M01118	WT1 (directAnnotation).
QKI	swissregulon__hs__KLF6	KLF6 (directAnnotation).
QKI	transfac_pro__M01303	SP1 (directAnnotation).
QKI	transfac_pro__M04595	SALL2 (directAnnotation).
QKI	tfdimers__MD00483	ZBTB14 (directAnnotation).
QKI	transfac_pro__M01837	KLF11 (directAnnotation).
QKI	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
QKI	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
QKI	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
QKI	transfac_pro__M07397	ZNF148 (directAnnotation).
QKI	transfac_pro__M12686	ZBTB10 (directAnnotation).
QKI	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."