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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PURA

Summary for PURA

Gene information	Gene symbol	PURA
	Ensembl ID	ENSG00000185129
	Entrez ID	5813
	Gene name	purine rich element binding protein A
	Synonyms	PUR-ALPHA\|PUR1\|PURALPHA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PURA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.314008	7.17e-24
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.781197	0.00e+00

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Expression of PURA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PURA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PURA	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PURA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PURA	hsa-miR-373-5p	82.6041	NM_005859
PURA	hsa-miR-371b-5p	82.6041	NM_005859
PURA	hsa-miR-616-5p	82.6041	NM_005859
PURA	hsa-miR-150-5p	81.8852	NM_005859
PURA	hsa-miR-3145-5p	81.8621	NM_005859
PURA	hsa-miR-4698	81.6996	NM_005859
PURA	hsa-miR-675-3p	81.4695	NM_005859
PURA	hsa-miR-101-3p	81.1481	NM_005859
PURA	hsa-miR-607	81.1284	NM_005859
PURA	hsa-miR-432-5p	80.7844	NM_005859
PURA	hsa-miR-8065	80.4311	NM_005859
PURA	hsa-miR-644a	80.0355	NM_005859
PURA	hsa-miR-4708-5p	80.0323	NM_005859
PURA	hsa-miR-657	80.029	NM_005859

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Motifs and transcription factors (TFs) regulating PURA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PURA	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PURA	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PURA	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PURA	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PURA	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PURA	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PURA	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PURA	cisbp__M00249	WT1 (directAnnotation).
PURA	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PURA	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PURA	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PURA	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PURA	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PURA	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PURA	transfac_pro__M02089	E2F3 (directAnnotation).
PURA	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PURA	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PURA	transfac_pro__M04817	ZBTB33 (directAnnotation).
PURA	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PURA	tfdimers__MD00483	ZBTB14 (directAnnotation).
PURA	cisbp__M07938	E2F1 (directAnnotation).
PURA	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PURA	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PURA	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PURA	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."