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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PTPN4

Summary for PTPN4

Gene information	Gene symbol	PTPN4
	Ensembl ID	ENSG00000088179
	Entrez ID	5775
	Gene name	protein tyrosine phosphatase non-receptor type 4
	Synonyms	PTPMEG
	Gene type	protein_coding
	UniProtAcc	P29074

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Dataset with differentially expressed gene: PTPN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.278424	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.284617	2.48e-07
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.297965	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.275351	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.366227	9.44e-40

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Expression of PTPN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTPN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTPN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPN4	hsa-miR-33b-3p	87.8808	NM_002830
PTPN4	hsa-miR-22-5p	87.8724	NM_002830
PTPN4	hsa-miR-6873-3p	87.7409	NM_002830
PTPN4	hsa-miR-5692a	87.7228	NM_002830
PTPN4	hsa-miR-8068	87.7166	NM_002830
PTPN4	hsa-miR-3617-5p	87.6894	NM_002830
PTPN4	hsa-miR-641	87.6894	NM_002830
PTPN4	hsa-miR-3936	87.6657	NM_002830
PTPN4	hsa-miR-4795-3p	87.6502	NM_002830
PTPN4	hsa-miR-5011-5p	87.2022	NM_002830
PTPN4	hsa-miR-4263	87.0235	NM_002830
PTPN4	hsa-miR-95-5p	86.9783	NM_002830
PTPN4	hsa-miR-2682-5p	86.8037	NM_002830
PTPN4	hsa-miR-3145-3p	86.7861	NM_002830
PTPN4	hsa-miR-4477a	86.5561	NM_002830
PTPN4	hsa-miR-466	86.3198	NM_002830
PTPN4	hsa-miR-125b-2-3p	86.3148	NM_002830
PTPN4	hsa-miR-4789-5p	86.18	NM_002830
PTPN4	hsa-miR-182-5p	86.0896	NM_002830
PTPN4	hsa-miR-4756-3p	86.0438	NM_002830
PTPN4	hsa-miR-126-5p	85.8411	NM_002830
PTPN4	hsa-miR-568	85.7479	NM_002830
PTPN4	hsa-miR-1277-5p	85.236	NM_002830
PTPN4	hsa-miR-6529-5p	85.1786	NM_002830
PTPN4	hsa-miR-3688-5p	84.9064	NM_002830
PTPN4	hsa-miR-936	84.7839	NM_002830
PTPN4	hsa-miR-5189-3p	84.7158	NM_002830
PTPN4	hsa-miR-6804-3p	84.5583	NM_002830
PTPN4	hsa-miR-515-3p	84.353	NM_002830
PTPN4	hsa-miR-130a-3p	84.2478	NM_002830
PTPN4	hsa-miR-6505-5p	84.1187	NM_002830
PTPN4	hsa-miR-6756-3p	83.9752	NM_002830
PTPN4	hsa-miR-3127-3p	83.9752	NM_002830
PTPN4	hsa-miR-138-5p	83.9589	NM_002830
PTPN4	hsa-miR-6131	83.9589	NM_002830
PTPN4	hsa-miR-605-5p	83.6861	NM_002830
PTPN4	hsa-miR-510-3p	83.5908	NM_002830
PTPN4	hsa-miR-4789-3p	83.5005	NM_002830
PTPN4	hsa-miR-512-3p	83.3599	NM_002830
PTPN4	hsa-miR-130b-3p	83.2463	NM_002830
PTPN4	hsa-miR-301a-3p	83.2463	NM_002830
PTPN4	hsa-miR-4295	83.2463	NM_002830
PTPN4	hsa-miR-3666	83.2463	NM_002830
PTPN4	hsa-miR-454-3p	83.2463	NM_002830
PTPN4	hsa-miR-301b-3p	83.2463	NM_002830
PTPN4	hsa-miR-143-5p	83.1357	NM_002830
PTPN4	hsa-miR-4799-5p	82.9895	NM_002830
PTPN4	hsa-miR-10523-5p	82.8519	NM_002830
PTPN4	hsa-miR-410-5p	82.8326	NM_002830
PTPN4	hsa-miR-494-5p	82.8326	NM_002830

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Motifs and transcription factors (TFs) regulating PTPN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPN4	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PTPN4	metacluster_141.4	GLIS2 (directAnnotation).
PTPN4	metacluster_144.10	ZNF100 (directAnnotation).
PTPN4	transfac_pro__M04861	SIX5 (directAnnotation).
PTPN4	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PTPN4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PTPN4	dbtfbs__WT1_HEK293_ENCSR966PJJ_merged_N1	WT1 (directAnnotation).
PTPN4	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
PTPN4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PTPN4	hdpi__NRL	NRL (directAnnotation).
PTPN4	transfac_pro__M07310	SP5 (directAnnotation).
PTPN4	cisbp__M07938	E2F1 (directAnnotation).
PTPN4	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PTPN4	cisbp__M00968	MTF2 (directAnnotation).
PTPN4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PTPN4	transfac_pro__M04817	ZBTB33 (directAnnotation).
PTPN4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PTPN4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PTPN4	tfdimers__MD00483	ZBTB14 (directAnnotation).
PTPN4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PTPN4	transfac_pro__M02089	E2F3 (directAnnotation).
PTPN4	transfac_pro__M07317	CTBP1 (directAnnotation).
PTPN4	transfac_pro__M12697	ZNF142 (directAnnotation).
PTPN4	transfac_pro__M00716	ZBTB14 (directAnnotation).
PTPN4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PTPN4	transfac_pro__M03806	ZBTB7C (directAnnotation).
PTPN4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PTPN4	transfac_pro__M04893	TAF1 (directAnnotation).
PTPN4	transfac_pro__M01253	CNOT3 (directAnnotation).
PTPN4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PTPN4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PTPN4	transfac_pro__M04916	TAF1 (directAnnotation).
PTPN4	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PTPN4	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PTPN4	hdpi__RARA	RARA (directAnnotation).
PTPN4	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PTPN4	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PTPN4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PTPN4	hdpi__HIP2	UBE2K (directAnnotation).
PTPN4	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PTPN4	hdpi__ZNF304	ZNF304 (directAnnotation).
PTPN4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PTPN4	cisbp__M08228	PAX5 (directAnnotation).
PTPN4	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PTPN4	transfac_pro__M00938	E2F1 (directAnnotation).
PTPN4	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PTPN4	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
PTPN4	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PTPN4	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
PTPN4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PTPN4	"Alendronic acid"	DB00630	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."