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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTBP3

Summary for PTBP3

Gene information	Gene symbol	PTBP3
	Ensembl ID	ENSG00000119314
	Entrez ID	9991
	Gene name	polypyrimidine tract binding protein 3
	Synonyms	DKFZp781I1117\|ROD1
	Gene type	protein_coding
	UniProtAcc	O95758

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Dataset with differentially expressed gene: PTBP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.356443	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.290309	1.23e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.298273	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.278439	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.271223	1.11e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.254099	6.93e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.260892	6.01e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.777753	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.501201	5.02e-15

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Expression of PTBP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTBP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTBP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTBP3	hsa-miR-1258	90.8959	NM_001163788
PTBP3	hsa-miR-3910	90.7588	NM_001163788
PTBP3	hsa-miR-4307	90.5037	NM_001244897
PTBP3	hsa-miR-4474-5p	89.9405	NM_001244897
PTBP3	hsa-miR-135a-3p	89.8537	NM_001244898
PTBP3	hsa-miR-519d-5p	89.1976	NM_001244898
PTBP3	hsa-miR-133a-3p	89.0799	NM_001163788
PTBP3	hsa-miR-133b	89.0799	NM_001163788
PTBP3	hsa-miR-499a-5p	89.0046	NM_001244897
PTBP3	hsa-miR-548ay-3p	88.9627	NM_001163788
PTBP3	hsa-miR-548at-3p	88.9627	NM_001163788
PTBP3	hsa-miR-29a-3p	88.8731	NM_001163788
PTBP3	hsa-miR-29c-3p	88.8731	NM_001163788
PTBP3	hsa-miR-29b-3p	88.8731	NM_001163788
PTBP3	hsa-miR-548az-5p	88.4045	NM_001163788
PTBP3	hsa-miR-548t-5p	88.4045	NM_001163788
PTBP3	hsa-miR-3714	88.2236	NM_001163788
PTBP3	hsa-miR-95-5p	88.1603	NM_001163788
PTBP3	hsa-miR-558	87.7154	NM_001244898
PTBP3	hsa-miR-4427	87.3945	NM_001163788
PTBP3	hsa-miR-4728-3p	87.1654	NM_001244898
PTBP3	hsa-miR-1255b-2-3p	87.1293	NM_001244898
PTBP3	hsa-miR-4484	86.7314	NM_001163788
PTBP3	hsa-miR-4460	86.3477	NM_001163788
PTBP3	hsa-miR-600	86.2644	NM_001163788
PTBP3	hsa-miR-4780	85.9768	NM_001244898
PTBP3	hsa-miR-5187-5p	85.854	NM_001244897
PTBP3	hsa-miR-6858-3p	85.4312	NM_001244897
PTBP3	hsa-miR-548ar-3p	85.3397	NM_001244897
PTBP3	hsa-miR-302a-5p	84.9483	NM_001244898
PTBP3	hsa-miR-3120-3p	84.5941	NM_001244898
PTBP3	hsa-miR-6768-5p	84.4486	NM_001163788
PTBP3	hsa-miR-6501-3p	84.2908	NM_001244897
PTBP3	hsa-miR-887-5p	84.2009	NM_001244898
PTBP3	hsa-miR-548az-3p	84.1815	NM_001244897
PTBP3	hsa-miR-548bc	84.1815	NM_001244897
PTBP3	hsa-miR-548f-3p	84.1815	NM_001244897
PTBP3	hsa-miR-548e-3p	84.1815	NM_001244897
PTBP3	hsa-miR-548a-3p	83.8009	NM_001244897
PTBP3	hsa-miR-625-5p	83.7061	NM_001244898
PTBP3	hsa-miR-3646	83.6849	NM_001244898
PTBP3	hsa-miR-7156-5p	83.6317	NM_001244897
PTBP3	hsa-miR-4496	83.4675	NM_001163788
PTBP3	hsa-miR-3145-3p	83.4192	NM_001244898
PTBP3	hsa-miR-3529-3p	83.1979	NM_001244897
PTBP3	hsa-miR-5683	83.1297	NM_001244897
PTBP3	hsa-miR-548n	83.0205	NM_001163788
PTBP3	hsa-miR-605-5p	82.9493	NM_001163788
PTBP3	hsa-miR-200b-3p	82.6382	NM_001244897
PTBP3	hsa-miR-200c-3p	82.6382	NM_001244897

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Motifs and transcription factors (TFs) regulating PTBP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTBP3	transfac_pro__M06213	ZNF267 (directAnnotation).
PTBP3	transfac_pro__M06035	ZNF749 (directAnnotation).
PTBP3	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
PTBP3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PTBP3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PTBP3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PTBP3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PTBP3	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
PTBP3	transfac_pro__M12686	ZBTB10 (directAnnotation).
PTBP3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PTBP3	metacluster_143.14	ZNF320 (directAnnotation).
PTBP3	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PTBP3	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
PTBP3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PTBP3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PTBP3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PTBP3	transfac_pro__M04617	ZBTB7A (directAnnotation).
PTBP3	transfac_pro__M01973	PLAG1 (directAnnotation).
PTBP3	metacluster_151.2	ZNF23 (directAnnotation).
PTBP3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PTBP3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PTBP3	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
PTBP3	cisbp__M01864	EGR1 (inferredBy_Orthology).
PTBP3	tfdimers__MD00391	KLF4 (directAnnotation).
PTBP3	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
PTBP3	tfdimers__MD00151	CHURC1 (directAnnotation).
PTBP3	transfac_pro__M04817	ZBTB33 (directAnnotation).
PTBP3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PTBP3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PTBP3	jaspar__MA1122.1	TFDP1 (directAnnotation).
PTBP3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PTBP3	transfac_pro__M01253	CNOT3 (directAnnotation).
PTBP3	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
PTBP3	cisbp__M00968	MTF2 (directAnnotation).
PTBP3	tfdimers__MD00038	TFAP2C (directAnnotation).
PTBP3	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
PTBP3	transfac_pro__M01199	TRIM28 (directAnnotation).
PTBP3	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
PTBP3	metacluster_3.14	WT1; WT1 (directAnnotation).
PTBP3	transfac_pro__M12697	ZNF142 (directAnnotation).
PTBP3	transfac_pro__M07387	ZBTB7A (directAnnotation).
PTBP3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PTBP3	transfac_pro__M04893	TAF1 (directAnnotation).
PTBP3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PTBP3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PTBP3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PTBP3	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
PTBP3	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
PTBP3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTBP3	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."