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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHF20L1

Summary for PHF20L1

Gene information	Gene symbol	PHF20L1
	Ensembl ID	ENSG00000129292
	Entrez ID	51105
	Gene name	PHD finger protein 20 like 1
	Synonyms	CGI-72\|FLJ13649\|FLJ21615\|MGC64923\|TDRD20B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHF20L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.260274	3.63e-06

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Expression of PHF20L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHF20L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHF20L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHF20L1	hsa-miR-548x-3p	82.7958	NM_001277196
PHF20L1	hsa-miR-4423-5p	82.7094	NM_001277196
PHF20L1	hsa-miR-4328	82.6663	NM_001277196
PHF20L1	hsa-miR-374a-3p	82.6266	NM_001277196
PHF20L1	hsa-miR-4282	82.382	NM_001277196
PHF20L1	hsa-miR-3619-5p	82.1297	NM_198513
PHF20L1	hsa-miR-6074	81.9348	NM_001277196
PHF20L1	hsa-miR-100-3p	81.7508	NM_001277196
PHF20L1	hsa-miR-6776-3p	81.6677	NM_001277196
PHF20L1	hsa-miR-5193	81.3374	NM_001277196
PHF20L1	hsa-miR-7162-3p	81.3069	NM_001277196
PHF20L1	hsa-miR-6813-3p	81.1667	NM_198513
PHF20L1	hsa-miR-6761-5p	81.1137	NM_001277196
PHF20L1	hsa-miR-7160-5p	81.0122	NM_001277196
PHF20L1	hsa-miR-548ae-3p	80.9285	NM_001277196
PHF20L1	hsa-miR-548aq-3p	80.9285	NM_001277196
PHF20L1	hsa-miR-548am-3p	80.9285	NM_001277196
PHF20L1	hsa-miR-548ah-3p	80.9285	NM_001277196
PHF20L1	hsa-miR-548j-3p	80.9285	NM_001277196
PHF20L1	hsa-miR-584-3p	80.84	NM_001277196
PHF20L1	hsa-miR-3977	80.683	NM_001277196
PHF20L1	hsa-miR-651-3p	80.4768	NM_198513
PHF20L1	hsa-miR-6830-5p	80.2892	NM_198513
PHF20L1	hsa-miR-4735-5p	80.27	NM_001277196
PHF20L1	hsa-miR-4424	80.1007	NM_198513

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Motifs and transcription factors (TFs) regulating PHF20L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHF20L1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PHF20L1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
PHF20L1	transfac_pro__M03806	ZBTB7C (directAnnotation).
PHF20L1	metacluster_198.3	ZFP64 (directAnnotation).
PHF20L1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PHF20L1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PHF20L1	hdpi__NRL	NRL (directAnnotation).
PHF20L1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PHF20L1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PHF20L1	metacluster_7.13	ZFX (directAnnotation).
PHF20L1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
PHF20L1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."