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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAN3

Summary for PAN3

Gene information	Gene symbol	PAN3
	Ensembl ID	ENSG00000152520
	Entrez ID	255967
	Gene name	poly(A) specific ribonuclease subunit PAN3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q58A45

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Dataset with differentially expressed gene: PAN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.268325	3.95e-08

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Expression of PAN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAN3	hsa-miR-944	84.0542	NM_175854
PAN3	hsa-miR-1264	84.0388	NM_175854
PAN3	hsa-miR-548bb-3p	83.8948	NM_175854
PAN3	hsa-miR-548d-3p	83.8948	NM_175854
PAN3	hsa-miR-548z	83.8948	NM_175854
PAN3	hsa-miR-548ac	83.8948	NM_175854
PAN3	hsa-miR-548h-3p	83.8948	NM_175854
PAN3	hsa-miR-610	83.8412	NM_175854
PAN3	hsa-miR-549a-5p	83.8119	NM_175854
PAN3	hsa-miR-4668-3p	83.5618	NM_175854
PAN3	hsa-miR-4677-5p	82.7765	NM_175854
PAN3	hsa-miR-892c-5p	82.6364	NM_175854
PAN3	hsa-miR-885-3p	82.5318	NM_175854
PAN3	hsa-miR-6759-3p	82.4243	NM_175854
PAN3	hsa-miR-544b	82.0635	NM_175854
PAN3	hsa-miR-4499	81.8754	NM_175854
PAN3	hsa-miR-506-5p	81.417	NM_175854
PAN3	hsa-miR-8066	81.2499	NM_175854
PAN3	hsa-miR-4470	81.0426	NM_175854
PAN3	hsa-miR-511-3p	80.8281	NM_175854
PAN3	hsa-miR-105-5p	80.5964	NM_175854
PAN3	hsa-miR-7853-5p	80.5964	NM_175854
PAN3	hsa-miR-202-5p	80.5516	NM_175854
PAN3	hsa-miR-1200	80.1736	NM_175854

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Motifs and transcription factors (TFs) regulating PAN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAN3	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
PAN3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PAN3	jaspar__MA1122.1	TFDP1 (directAnnotation).
PAN3	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
PAN3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PAN3	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PAN3	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."