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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ONECUT2

Summary for ONECUT2

Gene information	Gene symbol	ONECUT2
	Ensembl ID	ENSG00000119547
	Entrez ID	9480
	Gene name	one cut homeobox 2
	Synonyms	OC-2
	Gene type	protein_coding
	UniProtAcc	O95948

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Dataset with differentially expressed gene: ONECUT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.289482	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.944013	0.00e+00

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Expression of ONECUT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ONECUT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ONECUT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ONECUT2	hsa-miR-29a-5p	92.4638	NM_004852
ONECUT2	hsa-miR-651-3p	92.4333	NM_004852
ONECUT2	hsa-miR-548az-3p	92.3409	NM_004852
ONECUT2	hsa-miR-548bc	92.3409	NM_004852
ONECUT2	hsa-miR-548f-3p	92.3409	NM_004852
ONECUT2	hsa-miR-548e-3p	92.3409	NM_004852
ONECUT2	hsa-miR-3978	92.3311	NM_004852
ONECUT2	hsa-miR-665	92.2531	NM_004852
ONECUT2	hsa-miR-190a-3p	92.143	NM_004852
ONECUT2	hsa-miR-32-3p	92.0549	NM_004852
ONECUT2	hsa-miR-4261	92.0245	NM_004852
ONECUT2	hsa-miR-340-5p	91.9364	NM_004852
ONECUT2	hsa-miR-548a-3p	91.8226	NM_004852
ONECUT2	hsa-miR-6868-3p	91.7048	NM_004852
ONECUT2	hsa-miR-203b-3p	91.6852	NM_004852
ONECUT2	hsa-miR-181b-5p	91.3613	NM_004852
ONECUT2	hsa-miR-181a-5p	91.3613	NM_004852
ONECUT2	hsa-miR-181c-5p	91.3613	NM_004852
ONECUT2	hsa-miR-6839-5p	91.3561	NM_004852
ONECUT2	hsa-let-7d-5p	91.2178	NM_004852
ONECUT2	hsa-miR-1305	91.1988	NM_004852
ONECUT2	hsa-miR-648	91.1253	NM_004852
ONECUT2	hsa-miR-142-5p	90.953	NM_004852
ONECUT2	hsa-miR-5590-3p	90.953	NM_004852
ONECUT2	hsa-miR-2052	90.6134	NM_004852
ONECUT2	hsa-miR-378j	90.493	NM_004852
ONECUT2	hsa-miR-4504	90.4192	NM_004852
ONECUT2	hsa-miR-5688	90.3359	NM_004852
ONECUT2	hsa-miR-3160-5p	89.9929	NM_004852
ONECUT2	hsa-miR-1248	89.9884	NM_004852
ONECUT2	hsa-miR-627-3p	89.9511	NM_004852
ONECUT2	hsa-miR-513a-5p	89.947	NM_004852
ONECUT2	hsa-miR-6839-3p	89.9307	NM_004852
ONECUT2	hsa-miR-4263	89.93	NM_004852
ONECUT2	hsa-miR-935	89.8414	NM_004852
ONECUT2	hsa-miR-432-5p	89.8121	NM_004852
ONECUT2	hsa-miR-1273h-3p	89.8106	NM_004852
ONECUT2	hsa-miR-10527-5p	89.4573	NM_004852
ONECUT2	hsa-miR-6805-3p	89.4523	NM_004852
ONECUT2	hsa-miR-5691	89.4523	NM_004852
ONECUT2	hsa-miR-891b	89.3259	NM_004852
ONECUT2	hsa-miR-6513-3p	89.2998	NM_004852
ONECUT2	hsa-miR-194-5p	89.2028	NM_004852
ONECUT2	hsa-miR-4520-2-3p	88.9365	NM_004852
ONECUT2	hsa-miR-103a-2-5p	88.8974	NM_004852
ONECUT2	hsa-miR-103a-1-5p	88.8974	NM_004852
ONECUT2	hsa-miR-4420	88.8489	NM_004852
ONECUT2	hsa-miR-4651	88.8163	NM_004852
ONECUT2	hsa-miR-608	88.8163	NM_004852
ONECUT2	hsa-miR-4678	88.7961	NM_004852

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Motifs and transcription factors (TFs) regulating ONECUT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ONECUT2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ONECUT2	metacluster_7.13	ZFX (directAnnotation).
ONECUT2	transfac_pro__M01175	ZBTB7B (directAnnotation).
ONECUT2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ONECUT2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ONECUT2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ONECUT2	transfac_pro__M02089	E2F3 (directAnnotation).
ONECUT2	metacluster_3.14	WT1; WT1 (directAnnotation).
ONECUT2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ONECUT2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ONECUT2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ONECUT2	cisbp__M07938	E2F1 (directAnnotation).
ONECUT2	transfac_pro__M07436	WT1 (directAnnotation).
ONECUT2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ONECUT2	transfac_pro__M02898	SMAD3 (directAnnotation).
ONECUT2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ONECUT2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ONECUT2	cisbp__M00968	MTF2 (directAnnotation).
ONECUT2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ONECUT2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ONECUT2	cisbp__M00341	PAX6 (directAnnotation).
ONECUT2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ONECUT2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ONECUT2	cisbp__M00788	ZFY (inferredBy_Orthology).
ONECUT2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ONECUT2	hdpi__ZNF304	ZNF304 (directAnnotation).
ONECUT2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ONECUT2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ONECUT2	transfac_pro__M01199	TRIM28 (directAnnotation).
ONECUT2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ONECUT2	metacluster_151.2	ZNF23 (directAnnotation).
ONECUT2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ONECUT2	transfac_pro__M03806	ZBTB7C (directAnnotation).
ONECUT2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."