Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NRXN1

Summary for NRXN1

Gene information	Gene symbol	NRXN1
	Ensembl ID	ENSG00000179915
	Entrez ID	9378
	Gene name	neurexin 1
	Synonyms	Hs.22998\|KIAA0578
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: NRXN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.410188	0.00e+00

Top

Expression of NRXN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NRXN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NRXN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRXN1	hsa-miR-548g-5p	85.5193	NM_001135659
NRXN1	hsa-miR-548aj-5p	85.5193	NM_001135659
NRXN1	hsa-miR-548x-5p	85.5193	NM_001135659
NRXN1	hsa-miR-12126	85.5044	NM_001135659
NRXN1	hsa-miR-3162-5p	85.4886	NM_001135659
NRXN1	hsa-miR-4756-3p	85.3684	NM_138735
NRXN1	hsa-miR-4803	84.6504	NM_138735
NRXN1	hsa-miR-1264	84.3039	NM_001135659
NRXN1	hsa-miR-4480	84.1869	NM_001135659
NRXN1	hsa-miR-4677-5p	84.1803	NM_138735
NRXN1	hsa-miR-4282	83.9852	NM_001135659
NRXN1	hsa-miR-7853-5p	83.7144	NM_138735
NRXN1	hsa-miR-105-5p	83.7144	NM_138735
NRXN1	hsa-miR-218-5p	83.4079	NM_001135659
NRXN1	hsa-miR-3183	83.4078	NM_138735
NRXN1	hsa-miR-6769b-3p	83.4078	NM_138735
NRXN1	hsa-miR-4723-3p	83.4078	NM_138735
NRXN1	hsa-miR-548n	83.3672	NM_138735
NRXN1	hsa-miR-205-3p	83.1315	NM_001135659
NRXN1	hsa-miR-551b-5p	83.1213	NM_001135659
NRXN1	hsa-miR-1468-3p	82.542	NM_001135659
NRXN1	hsa-miR-216a-3p	82.4992	NM_138735
NRXN1	hsa-miR-128-3p	82.4992	NM_138735
NRXN1	hsa-miR-670-5p	82.477	NM_001135659
NRXN1	hsa-miR-103a-1-5p	82.4035	NM_001135659
NRXN1	hsa-miR-103a-2-5p	82.4035	NM_001135659
NRXN1	hsa-miR-7159-3p	82.1855	NM_138735
NRXN1	hsa-miR-3134	82.0397	NM_001135659
NRXN1	hsa-miR-4753-3p	81.6647	NM_138735
NRXN1	hsa-miR-6797-3p	81.349	NM_001135659
NRXN1	hsa-miR-511-5p	81.2193	NM_138735
NRXN1	hsa-miR-297	81.0196	NM_138735
NRXN1	hsa-miR-181c-5p	80.7187	NM_001135659
NRXN1	hsa-miR-181d-5p	80.7187	NM_001135659
NRXN1	hsa-miR-181a-5p	80.7187	NM_001135659
NRXN1	hsa-miR-4262	80.7187	NM_001135659
NRXN1	hsa-miR-181b-5p	80.7187	NM_001135659
NRXN1	hsa-miR-130b-5p	80.3898	NM_138735
NRXN1	hsa-miR-3681-3p	80.3639	NM_138735
NRXN1	hsa-miR-5588-5p	80.1496	NM_138735
NRXN1	hsa-miR-548an	80.0727	NM_001135659

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating NRXN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRXN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NRXN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NRXN1	transfac_pro__M07397	ZNF148 (directAnnotation).
NRXN1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NRXN1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NRXN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NRXN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NRXN1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NRXN1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NRXN1	tfdimers__MD00151	CHURC1 (directAnnotation).
NRXN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NRXN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NRXN1	transfac_pro__M01303	SP1 (directAnnotation).
NRXN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NRXN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NRXN1	transfac_pro__M02090	E2F4 (directAnnotation).
NRXN1	transfac_pro__M01714	KLF15 (directAnnotation).
NRXN1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NRXN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NRXN1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NRXN1	transfac_pro__M02089	E2F3 (directAnnotation).
NRXN1	metacluster_3.14	WT1; WT1 (directAnnotation).
NRXN1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NRXN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NRXN1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NRXN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NRXN1	cisbp__M07938	E2F1 (directAnnotation).
NRXN1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NRXN1	transfac_pro__M07436	WT1 (directAnnotation).
NRXN1	transfac_pro__M02281	SP1 (directAnnotation).
NRXN1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NRXN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NRXN1	transfac_pro__M02898	SMAD3 (directAnnotation).
NRXN1	transfac_public__M00491	PATZ1 (directAnnotation).
NRXN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NRXN1	"Calcium citrate"	DB11093	small molecule
NRXN1	"Calcium phosphate dihydrate"	DB14481	small molecule
NRXN1	"Calcium Phosphate"	DB11348	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."