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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NAV1

Summary for NAV1

Gene information	Gene symbol	NAV1
	Ensembl ID	ENSG00000134369
	Entrez ID	89796
	Gene name	neuron navigator 1
	Synonyms	DKFZp781D0314\|FLJ12560\|FLJ14203\|KIAA1151\|MGC14961\|POMFIL3\|steerin-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NAV1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.423773	1.86e-20
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.25406	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.43395	0.00e+00

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Expression of NAV1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NAV1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NAV1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NAV1	hsa-miR-6878-5p	81.2636	NM_001167738
NAV1	hsa-miR-30c-2-3p	81.2216	NM_001167738
NAV1	hsa-miR-10526-3p	81.1807	NM_001167738
NAV1	hsa-miR-4632-5p	81.0704	NM_001167738
NAV1	hsa-miR-7150	80.9913	NM_001167738
NAV1	hsa-miR-4261	80.969	NM_001167738
NAV1	hsa-miR-423-5p	80.8057	NM_001167738
NAV1	hsa-miR-3184-5p	80.8057	NM_001167738
NAV1	hsa-miR-1915-5p	80.7778	NM_001167738
NAV1	hsa-miR-148a-5p	80.7487	NM_001167738
NAV1	hsa-miR-3180-5p	80.7371	NM_001167738
NAV1	hsa-miR-1199-5p	80.6967	NM_001167738
NAV1	hsa-miR-6751-3p	80.6967	NM_001167738
NAV1	hsa-miR-6814-5p	80.5165	NM_001167738
NAV1	hsa-miR-5584-5p	80.2763	NM_001167738
NAV1	hsa-miR-6888-5p	80.213	NM_001167738
NAV1	hsa-miR-3529-3p	80.1306	NM_001167738
NAV1	hsa-miR-4514	80.1217	NM_001167738

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Motifs and transcription factors (TFs) regulating NAV1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NAV1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NAV1	hdpi__ETV4	ETV4 (directAnnotation).
NAV1	jaspar__MA0079.5	SP1 (directAnnotation).
NAV1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NAV1	metacluster_55.5	ZNF541 (directAnnotation).
NAV1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
NAV1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."