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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOB1B

Summary for MOB1B

Gene information	Gene symbol	MOB1B
	Ensembl ID	ENSG00000173542
	Entrez ID	92597
	Gene name	MOB kinase activator 1B
	Synonyms	MOB4A\|MOBKL1A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MOB1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.423091	3.64e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.274833	0.00e+00

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Expression of MOB1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOB1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOB1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOB1B	hsa-miR-302a-5p	84.6421	NM_001244766
MOB1B	hsa-miR-548n	84.4046	NM_173468
MOB1B	hsa-miR-3685	83.8886	NM_173468
MOB1B	hsa-miR-576-5p	83.8315	NM_173468
MOB1B	hsa-miR-433-3p	83.6108	NM_001244767
MOB1B	hsa-miR-3925-5p	83.2187	NM_173468
MOB1B	hsa-miR-548t-3p	82.7658	NM_173468
MOB1B	hsa-miR-548ap-3p	82.7658	NM_173468
MOB1B	hsa-miR-548aa	82.7658	NM_173468
MOB1B	hsa-miR-186-5p	82.6098	NM_173468
MOB1B	hsa-miR-3926	82.4497	NM_001244766
MOB1B	hsa-miR-10526-3p	82.3871	NM_001244767
MOB1B	hsa-miR-6787-3p	82.2788	NM_173468
MOB1B	hsa-miR-4496	82.0423	NM_173468
MOB1B	hsa-miR-507	81.9795	NM_001244766
MOB1B	hsa-miR-12128	81.9109	NM_001244767
MOB1B	hsa-miR-181b-3p	81.8338	NM_173468
MOB1B	hsa-miR-181b-2-3p	81.8338	NM_173468
MOB1B	hsa-miR-4420	81.8338	NM_173468
MOB1B	hsa-miR-548t-5p	81.4474	NM_173468
MOB1B	hsa-miR-548az-5p	81.4474	NM_173468
MOB1B	hsa-miR-557	81.3105	NM_001244766
MOB1B	hsa-miR-1250-3p	81.0049	NM_001244766
MOB1B	hsa-miR-545-3p	80.7103	NM_173468
MOB1B	hsa-miR-4762-3p	80.4332	NM_001244766
MOB1B	hsa-let-7c-3p	80.1074	NM_001244766
MOB1B	hsa-miR-6833-3p	80.0309	NM_173468

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Motifs and transcription factors (TFs) regulating MOB1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MOB1B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MOB1B	transfac_pro__M01122	ZNF219 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MOB1B	metacluster_7.13	ZFX (directAnnotation).
MOB1B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MOB1B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MOB1B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MOB1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MOB1B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MOB1B	transfac_pro__M01253	CNOT3 (directAnnotation).
MOB1B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MOB1B	jaspar__MA1721.1	ZNF93 (directAnnotation).
MOB1B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MOB1B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MOB1B	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
MOB1B	cisbp__M00341	PAX6 (directAnnotation).
MOB1B	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MOB1B	transfac_pro__M01199	TRIM28 (directAnnotation).
MOB1B	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
MOB1B	tfdimers__MD00151	CHURC1 (directAnnotation).
MOB1B	tfdimers__MD00391	KLF4 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
MOB1B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MOB1B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MOB1B	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
MOB1B	transfac_public__M00491	PATZ1 (directAnnotation).
MOB1B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MOB1B	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MOB1B	transfac_pro__M06126	ZNF43 (directAnnotation).
MOB1B	metacluster_144.12	ZNF419; ZNF773 (directAnnotation).
MOB1B	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."