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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MECP2

Summary for MECP2

Gene information	Gene symbol	MECP2
	Ensembl ID	ENSG00000169057
	Entrez ID	4204
	Gene name	methyl-CpG binding protein 2
	Synonyms	MRX16\|MRX79\|RTT
	Gene type	protein_coding
	UniProtAcc	P51608

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Dataset with differentially expressed gene: MECP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.591836	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.276574	9.86e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.333016	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.28504	2.15e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.302988	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.656126	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.270721	0.00e+00

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Expression of MECP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MECP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MECP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MECP2	hsa-miR-12118	87.9169	NM_004992
MECP2	hsa-miR-3173-3p	87.9169	NM_004992
MECP2	hsa-miR-548am-5p	87.9064	NM_004992
MECP2	hsa-miR-548as-5p	87.9064	NM_004992
MECP2	hsa-miR-548i	87.9064	NM_004992
MECP2	hsa-miR-548b-5p	87.9064	NM_004992
MECP2	hsa-miR-548ae-5p	87.9064	NM_004992
MECP2	hsa-miR-548o-5p	87.9064	NM_004992
MECP2	hsa-miR-548j-5p	87.9064	NM_004992
MECP2	hsa-miR-548bb-5p	87.9064	NM_004992
MECP2	hsa-miR-548ay-5p	87.9064	NM_004992
MECP2	hsa-miR-548a-5p	87.9064	NM_004992
MECP2	hsa-miR-548w	87.9064	NM_004992
MECP2	hsa-miR-548d-5p	87.9064	NM_004992
MECP2	hsa-miR-548ar-5p	87.9064	NM_004992
MECP2	hsa-miR-548ad-5p	87.9064	NM_004992
MECP2	hsa-miR-548c-5p	87.9064	NM_004992
MECP2	hsa-miR-548ap-5p	87.9064	NM_004992
MECP2	hsa-miR-548au-5p	87.9064	NM_004992
MECP2	hsa-miR-548ab	87.9064	NM_004992
MECP2	hsa-miR-548y	87.9064	NM_004992
MECP2	hsa-miR-548ak	87.9064	NM_004992
MECP2	hsa-miR-548h-5p	87.9064	NM_004992
MECP2	hsa-miR-7110-5p	87.8118	NM_004992
MECP2	hsa-miR-6842-5p	87.8118	NM_004992
MECP2	hsa-miR-637	87.7839	NM_004992
MECP2	hsa-miR-548e-3p	87.6089	NM_004992
MECP2	hsa-miR-548ar-3p	87.6089	NM_004992
MECP2	hsa-miR-548az-3p	87.6089	NM_004992
MECP2	hsa-miR-548bc	87.6089	NM_004992
MECP2	hsa-miR-942-5p	87.456	NM_004992
MECP2	hsa-miR-548aq-5p	87.3831	NM_004992
MECP2	hsa-miR-3194-3p	87.1665	NM_004992
MECP2	hsa-miR-1251-3p	87.1025	NM_004992
MECP2	hsa-miR-1251-5p	87.0017	NM_004992
MECP2	hsa-miR-4481	86.8191	NM_004992
MECP2	hsa-miR-6127	86.7869	NM_004992
MECP2	hsa-miR-374b-5p	86.685	NM_004992
MECP2	hsa-miR-374a-5p	86.0469	NM_004992
MECP2	hsa-miR-6785-5p	86.0459	NM_004992
MECP2	hsa-miR-149-3p	86.0459	NM_004992
MECP2	hsa-miR-6883-5p	86.0459	NM_004992
MECP2	hsa-miR-4728-5p	86.0459	NM_004992
MECP2	hsa-miR-4763-3p	85.9919	NM_004992
MECP2	hsa-miR-4731-5p	85.9758	NM_004992
MECP2	hsa-miR-6501-3p	85.909	NM_004992
MECP2	hsa-miR-4509	85.6235	NM_004992
MECP2	hsa-miR-766-3p	85.4617	NM_004992
MECP2	hsa-miR-4299	85.4519	NM_004992
MECP2	hsa-miR-1301-3p	85.4383	NM_004992

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Motifs and transcription factors (TFs) regulating MECP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MECP2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
MECP2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MECP2	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
MECP2	hdpi__TP73	TP73 (directAnnotation).
MECP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MECP2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
MECP2	transfac_pro__M04862	NRF1 (directAnnotation).
MECP2	jaspar__MA0748.2	YY2 (directAnnotation).
MECP2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MECP2	transfac_pro__M00430	E2F1 (directAnnotation).
MECP2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MECP2	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
MECP2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
MECP2	hdpi__HIP2	UBE2K (directAnnotation).
MECP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MECP2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
MECP2	metacluster_191.5	SPDEF (inferredBy_Orthology).
MECP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MECP2	transfac_pro__M00938	E2F1 (directAnnotation).
MECP2	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
MECP2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
MECP2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MECP2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
MECP2	jaspar__MA1721.1	ZNF93 (directAnnotation).
MECP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MECP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
MECP2	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
MECP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MECP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MECP2	cisbp__M00249	WT1 (directAnnotation).
MECP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MECP2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MECP2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MECP2	transfac_pro__M01253	CNOT3 (directAnnotation).
MECP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MECP2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
MECP2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
MECP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
MECP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MECP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
MECP2	transfac_pro__M12697	ZNF142 (directAnnotation).
MECP2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
MECP2	transfac_pro__M01973	PLAG1 (directAnnotation).
MECP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MECP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
MECP2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MECP2	transfac_pro__M01303	SP1 (directAnnotation).
MECP2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
MECP2	metacluster_143.13	ZBTB7A (directAnnotation).
MECP2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MECP2	metacluster_135.10	up	CD8+ T cells	GSE164551	NA
MECP2	transfac_pro__M01298	down	Malignant cells	GSE186960	NA
MECP2	metacluster_135.10	down	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."