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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LARP4

Summary for LARP4

Gene information	Gene symbol	LARP4
	Ensembl ID	ENSG00000161813
	Entrez ID	113251
	Gene name	La ribonucleoprotein 4
	Synonyms	PP13296
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LARP4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.29408	1.10e-06

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Expression of LARP4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LARP4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LARP4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LARP4	hsa-miR-548as-5p	82.9479	NM_052879
LARP4	hsa-miR-548i	82.9479	NM_052879
LARP4	hsa-miR-548ae-5p	82.9479	NM_052879
LARP4	hsa-miR-548o-5p	82.9479	NM_052879
LARP4	hsa-miR-548b-5p	82.9479	NM_052879
LARP4	hsa-miR-548h-5p	82.9479	NM_052879
LARP4	hsa-miR-5585-3p	82.8735	NM_052879
LARP4	hsa-miR-497-3p	82.6355	NM_052879
LARP4	hsa-miR-603	82.5423	NM_052879
LARP4	hsa-miR-548e-5p	82.5136	NM_052879
LARP4	hsa-miR-27a-3p	82.2506	NM_052879
LARP4	hsa-miR-9985	82.2506	NM_052879
LARP4	hsa-miR-27b-3p	82.2506	NM_052879
LARP4	hsa-miR-3973	82.1731	NM_052879
LARP4	hsa-miR-3613-3p	82.172	NM_052879
LARP4	hsa-miR-491-3p	81.7218	NM_052879
LARP4	hsa-miR-676-5p	81.5306	NM_001170804
LARP4	hsa-miR-4251	81.3272	NM_052879
LARP4	hsa-miR-548aj-3p	81.1427	NM_052879
LARP4	hsa-miR-548x-3p	81.1427	NM_052879
LARP4	hsa-miR-1305	80.9837	NM_052879
LARP4	hsa-miR-33a-3p	80.8527	NM_052879
LARP4	hsa-miR-6884-3p	80.56	NM_052879
LARP4	hsa-miR-6083	80.4878	NM_052879
LARP4	hsa-miR-513a-3p	80.1133	NM_052879
LARP4	hsa-miR-513c-3p	80.1133	NM_052879

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Motifs and transcription factors (TFs) regulating LARP4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LARP4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LARP4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LARP4	metacluster_7.13	ZFX (directAnnotation).
LARP4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LARP4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LARP4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LARP4	metacluster_198.3	ZFP64 (directAnnotation).
LARP4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LARP4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LARP4	cisbp__M00788	ZFY (inferredBy_Orthology).
LARP4	metacluster_175.1	ZNF283 (directAnnotation).
LARP4	hdpi__ZNF304	ZNF304 (directAnnotation).
LARP4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LARP4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."