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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KRAS

Summary for KRAS

Gene information	Gene symbol	KRAS
	Ensembl ID	ENSG00000133703
	Entrez ID	3845
	Gene name	KRAS proto-oncogene, GTPase
	Synonyms	K-Ras4B\|KRAS1\|KRAS2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KRAS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.257986	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.450882	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.625032	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.44312	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.299199	0.00e+00

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Expression of KRAS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KRAS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
KRAS	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating KRAS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KRAS	hsa-miR-3117-3p	82.8393	NM_033360
KRAS	hsa-miR-4433a-5p	82.6637	NM_004985
KRAS	hsa-miR-580-5p	82.4039	NM_004985
KRAS	hsa-miR-12124	81.9143	NM_004985
KRAS	hsa-miR-433-3p	81.7861	NM_004985
KRAS	hsa-miR-335-3p	81.6977	NM_004985
KRAS	hsa-miR-4659a-3p	81.2573	NM_033360
KRAS	hsa-miR-4659b-3p	81.2573	NM_033360
KRAS	hsa-miR-3916	81.1678	NM_033360
KRAS	hsa-miR-6859-5p	81.1678	NM_033360
KRAS	hsa-miR-7853-5p	81.1584	NM_004985
KRAS	hsa-miR-105-5p	81.1584	NM_004985
KRAS	hsa-miR-3688-3p	81.113	NM_033360
KRAS	hsa-miR-8062	81.0365	NM_004985
KRAS	hsa-miR-142-5p	80.5838	NM_004985
KRAS	hsa-miR-4422	80.5555	NM_004985
KRAS	hsa-miR-5590-3p	80.4795	NM_004985
KRAS	hsa-miR-590-3p	80.3593	NM_004985
KRAS	hsa-miR-30b-5p	80.0595	NM_033360
KRAS	hsa-miR-30d-5p	80.0595	NM_033360
KRAS	hsa-miR-30e-5p	80.0595	NM_033360
KRAS	hsa-miR-30a-5p	80.0595	NM_033360
KRAS	hsa-miR-30c-5p	80.0595	NM_033360
KRAS	hsa-miR-1255b-2-3p	80.0043	NM_004985

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Motifs and transcription factors (TFs) regulating KRAS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KRAS	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KRAS	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
KRAS	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KRAS	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
KRAS	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
KRAS	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KRAS	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KRAS	metacluster_3.14	WT1; WT1 (directAnnotation).
KRAS	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
KRAS	cisbp__M07938	E2F1 (directAnnotation).
KRAS	transfac_pro__M06035	ZNF749 (directAnnotation).
KRAS	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
KRAS	metacluster_52.11	ZNF184 (directAnnotation).
KRAS	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
KRAS	metacluster_135.11	NR2C2 (directAnnotation).
KRAS	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KRAS	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KRAS	metacluster_7.13	ZFX (directAnnotation).
KRAS	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KRAS	cisbp__M00968	MTF2 (directAnnotation).
KRAS	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KRAS	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KRAS	cisbp__M00341	PAX6 (directAnnotation).
KRAS	metacluster_198.3	ZFP64 (directAnnotation).
KRAS	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KRAS	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KRAS	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KRAS	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
KRAS	cisbp__M00788	ZFY (inferredBy_Orthology).
KRAS	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KRAS	metacluster_175.1	ZNF283 (directAnnotation).
KRAS	hdpi__ZNF304	ZNF304 (directAnnotation).
KRAS	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KRAS	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KRAS	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KRAS	transfac_pro__M01199	TRIM28 (directAnnotation).
KRAS	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
KRAS	metacluster_151.2	ZNF23 (directAnnotation).
KRAS	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KRAS	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KRAS	transfac_pro__M03806	ZBTB7C (directAnnotation).
KRAS	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KRAS	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
KRAS	cisbp__M00249	WT1 (directAnnotation).
KRAS	transfac_pro__M01122	ZNF219 (directAnnotation).
KRAS	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KRAS	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
KRAS	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
KRAS	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
KRAS	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KRAS	"Adagrasib"	DB15568	small molecule
KRAS	"Farnesyl diphosphate"	DB07780	small molecule
KRAS	"Sotorasib"	DB15569	small molecule
KRAS	"[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID"	DB07771	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."