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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: KLF7

Summary for KLF7

Gene information	Gene symbol	KLF7
	Ensembl ID	ENSG00000118263
	Entrez ID	8609
	Gene name	KLF transcription factor 7
	Synonyms	UKLF
	Gene type	protein_coding
	UniProtAcc	O75840

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Dataset with differentially expressed gene: KLF7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.49749	4.90e-03
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.42717	8.63e-30
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.828663	0.00e+00

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Expression of KLF7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLF7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLF7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLF7	hsa-miR-4693-3p	85.426	NM_001270944
KLF7	hsa-miR-153-3p	85.3439	NM_001270944
KLF7	hsa-miR-4635	85.3351	NM_001270944
KLF7	hsa-miR-4789-3p	85.1786	NM_001270944
KLF7	hsa-miR-4251	85.0091	NM_001270942
KLF7	hsa-miR-548an	84.8322	NM_001270944
KLF7	hsa-miR-10b-3p	84.557	NM_001270944
KLF7	hsa-miR-6793-3p	84.3248	NM_001270944
KLF7	hsa-miR-466	84.1512	NM_001270944
KLF7	hsa-miR-1972	84.0525	NM_001270942
KLF7	hsa-miR-200b-5p	84.0337	NM_001270944
KLF7	hsa-miR-200a-5p	84.0337	NM_001270944
KLF7	hsa-miR-2467-5p	83.7989	NM_001270942
KLF7	hsa-miR-4316	83.5927	NM_001270942
KLF7	hsa-miR-369-3p	83.4306	NM_001270944
KLF7	hsa-miR-4327	83.0854	NM_001270942
KLF7	hsa-miR-6809-5p	82.885	NM_001270942
KLF7	hsa-miR-4531	82.8428	NM_001270942
KLF7	hsa-miR-617	82.4586	NM_001270944
KLF7	hsa-miR-5692a	82.3736	NM_001270942
KLF7	hsa-miR-3133	82.0142	NM_001270942
KLF7	hsa-miR-3679-3p	81.7719	NM_001270944
KLF7	hsa-let-7g-3p	81.5298	NM_001270944
KLF7	hsa-let-7a-2-3p	81.5298	NM_001270944
KLF7	hsa-miR-450b-3p	81.4442	NM_001270942
KLF7	hsa-miR-587	81.2297	NM_001270942
KLF7	hsa-miR-7160-5p	81.1752	NM_001270942
KLF7	hsa-miR-147a	81.0755	NM_001270944
KLF7	hsa-miR-4644	80.7732	NM_001270942
KLF7	hsa-miR-6780a-5p	80.4168	NM_001270942
KLF7	hsa-miR-548ar-3p	80.3681	NM_001270944
KLF7	hsa-miR-498-5p	80.2768	NM_001270942
KLF7	hsa-miR-4659a-3p	80.178	NM_001270942
KLF7	hsa-miR-4659b-3p	80.178	NM_001270942

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Motifs and transcription factors (TFs) regulating KLF7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLF7	metacluster_141.2	E2F2; E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
KLF7	metacluster_195.2	up	Malignant cells	GSE140440	NA
KLF7	transfac_pro__M07461	up	Malignant cells	GSE140440	NA
KLF7	metacluster_170.2	up	Malignant cells	GSE140440	NA
KLF7	metacluster_163.1	down	Malignant cells	GSE153697	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."