Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KAT6A

Summary for KAT6A

Gene information	Gene symbol	KAT6A
	Ensembl ID	ENSG00000083168
	Entrez ID	7994
	Gene name	lysine acetyltransferase 6A
	Synonyms	MOZ\|MYST3\|RUNXBP2\|ZC2HC6A\|ZNF220
	Gene type	protein_coding
	UniProtAcc	Q92794

Top

Dataset with differentially expressed gene: KAT6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.252146	8.94e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.330635	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.272643	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.491049	0.00e+00

Top

Expression of KAT6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to KAT6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
KAT6A	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating KAT6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KAT6A	hsa-miR-8065	84.8196	NM_006766
KAT6A	hsa-miR-8066	84.7582	NM_001305878
KAT6A	hsa-miR-576-5p	84.5616	NM_006766
KAT6A	hsa-miR-3173-3p	84.4562	NM_006766
KAT6A	hsa-miR-12118	84.4562	NM_006766
KAT6A	hsa-miR-1276	84.113	NM_006766
KAT6A	hsa-miR-512-3p	83.5232	NM_006766
KAT6A	hsa-miR-3646	83.3967	NM_006766
KAT6A	hsa-miR-29b-1-5p	83.0207	NM_006766
KAT6A	hsa-miR-488-3p	82.6913	NM_006766
KAT6A	hsa-miR-3174	82.3763	NM_006766
KAT6A	hsa-miR-4308	82.206	NM_006766
KAT6A	hsa-miR-4263	81.2773	NM_006766
KAT6A	hsa-miR-12132	81.0503	NM_006766
KAT6A	hsa-miR-766-5p	80.9363	NM_006766
KAT6A	hsa-miR-655-5p	80.9292	NM_006766
KAT6A	hsa-miR-10526-3p	80.8615	NM_006766
KAT6A	hsa-miR-4738-3p	80.8321	NM_006766
KAT6A	hsa-miR-889-5p	80.7498	NM_006766
KAT6A	hsa-miR-6828-5p	80.5996	NM_006766
KAT6A	hsa-miR-6864-3p	80.4584	NM_006766
KAT6A	hsa-miR-3672	80.4584	NM_006766

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating KAT6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KAT6A	metacluster_22.37	BACH1 (directAnnotation).
KAT6A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
KAT6A	transfac_pro__M01253	CNOT3 (directAnnotation).
KAT6A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KAT6A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KAT6A	transfac_pro__M04916	TAF1 (directAnnotation).
KAT6A	transfac_pro__M12697	ZNF142 (directAnnotation).
KAT6A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KAT6A	tfdimers__MD00038	TFAP2C (directAnnotation).
KAT6A	metacluster_7.13	ZFX (directAnnotation).
KAT6A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KAT6A	cisbp__M00968	MTF2 (directAnnotation).
KAT6A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KAT6A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KAT6A	cisbp__M00341	PAX6 (directAnnotation).
KAT6A	metacluster_198.3	ZFP64 (directAnnotation).
KAT6A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KAT6A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KAT6A	cisbp__M00788	ZFY (inferredBy_Orthology).
KAT6A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KAT6A	metacluster_175.1	ZNF283 (directAnnotation).
KAT6A	hdpi__ZNF304	ZNF304 (directAnnotation).
KAT6A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KAT6A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KAT6A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KAT6A	transfac_pro__M01199	TRIM28 (directAnnotation).
KAT6A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
KAT6A	metacluster_151.2	ZNF23 (directAnnotation).
KAT6A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KAT6A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KAT6A	transfac_pro__M03806	ZBTB7C (directAnnotation).
KAT6A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KAT6A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
KAT6A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
KAT6A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
KAT6A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
KAT6A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
KAT6A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
KAT6A	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
KAT6A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
KAT6A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
KAT6A	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
KAT6A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KAT6A	jaspar__MA0748.2	YY2 (directAnnotation).
KAT6A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KAT6A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KAT6A	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
KAT6A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
KAT6A	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
KAT6A	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."