Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: IGF1

Summary for IGF1

Gene information	Gene symbol	IGF1
	Ensembl ID	ENSG00000017427
	Entrez ID	3479
	Gene name	insulin like growth factor 1
	Synonyms	IGF\|IGF-I\|IGF1A\|IGFI
	Gene type	protein_coding
	UniProtAcc	P05019

Top

Dataset with differentially expressed gene: IGF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	1.01749	1.26e-44
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.535036	4.68e-19
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.292735	0.00e+00

Top

Expression of IGF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to IGF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating IGF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IGF1	hsa-miR-1827	86.4145	NM_001111283
IGF1	hsa-miR-4723-3p	86.4043	NM_001111283
IGF1	hsa-miR-3183	86.4043	NM_001111283
IGF1	hsa-miR-6769b-3p	86.4043	NM_001111283
IGF1	hsa-miR-519c-3p	85.9691	NM_001111283
IGF1	hsa-miR-519b-3p	85.9691	NM_001111283
IGF1	hsa-miR-519a-3p	85.9691	NM_001111283
IGF1	hsa-miR-548u	85.7088	NM_001111283
IGF1	hsa-miR-205-3p	85.5142	NM_001111283
IGF1	hsa-miR-613	85.277	NM_001111283
IGF1	hsa-miR-1255b-2-3p	84.825	NM_001111283
IGF1	hsa-miR-4793-5p	84.6189	NM_001111283
IGF1	hsa-miR-8076	84.5988	NM_001111283
IGF1	hsa-miR-3685	84.1065	NM_001111283
IGF1	hsa-miR-551b-5p	83.2877	NM_001111283
IGF1	hsa-miR-12135	83.177	NM_000618
IGF1	hsa-miR-4633-5p	82.8678	NM_000618
IGF1	hsa-miR-6871-3p	82.5224	NM_001111283
IGF1	hsa-miR-4711-3p	82.1197	NM_000618
IGF1	hsa-miR-7159-5p	82.0422	NM_000618
IGF1	hsa-miR-4500	81.796	NM_001111283
IGF1	hsa-miR-3926	81.6725	NM_001111283
IGF1	hsa-miR-6733-5p	81.3942	NM_001111283
IGF1	hsa-miR-6739-5p	81.3942	NM_001111283
IGF1	hsa-miR-592	81.0183	NM_000618
IGF1	hsa-miR-7159-3p	80.5942	NM_001111283
IGF1	hsa-miR-4649-3p	80.2216	NM_000618

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating IGF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IGF1	transfac_public__M00039	CREB1 (directAnnotation).
IGF1	transfac_pro__M04746	E2F1 (directAnnotation).
IGF1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
IGF1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
IGF1	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTAATAAAN_CAP	ETV1; HOXD12 (directAnnotation).
IGF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
IGF1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
IGF1	transfac_pro__M05768	ZNF544 (directAnnotation).
IGF1	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
IGF1	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
IGF1	transfac_pro__M06259	ZNF91 (directAnnotation).
IGF1	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
IGF1	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
IGF1	jaspar__MA1125.1	ZNF384 (directAnnotation).
IGF1	taipale_tf_pairs__GCM1_HOXB13_RTGCGGGTAATAAAN_CAP	GCM1; HOXB13 (directAnnotation).
IGF1	transfac_pro__M04844	MAX (directAnnotation).
IGF1	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
IGF1	jaspar__MA1967.1	TFAP4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
IGF1	"N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide"	DB01890	small molecule
IGF1	"N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate"	DB02643	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."