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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPM6A

Summary for GPM6A

Gene information	Gene symbol	GPM6A
	Ensembl ID	ENSG00000150625
	Entrez ID	2823
	Gene name	glycoprotein M6A
	Synonyms	GPM6
	Gene type	protein_coding
	UniProtAcc	P51674

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Dataset with differentially expressed gene: GPM6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.350454	3.22e-02

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Expression of GPM6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPM6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPM6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPM6A	hsa-miR-3662	84.509	NM_001261447
GPM6A	hsa-miR-5003-3p	83.6103	NM_001261447
GPM6A	hsa-miR-95-5p	82.677	NM_001261447
GPM6A	hsa-miR-205-5p	82.5344	NM_001261447
GPM6A	hsa-miR-6837-5p	82.1146	NM_001261447
GPM6A	hsa-miR-4685-5p	82.1146	NM_001261447
GPM6A	hsa-miR-3923	81.746	NM_001261447
GPM6A	hsa-miR-1193	81.6079	NM_001261447
GPM6A	hsa-miR-510-5p	81.2876	NM_001261447
GPM6A	hsa-miR-5582-3p	81.1257	NM_001261447
GPM6A	hsa-miR-139-5p	81.0592	NM_001261447
GPM6A	hsa-miR-5003-5p	80.9071	NM_001261447
GPM6A	hsa-miR-505-3p	80.807	NM_001261447
GPM6A	hsa-miR-3973	80.6181	NM_001261447
GPM6A	hsa-miR-6775-3p	80.4183	NM_001261447

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Motifs and transcription factors (TFs) regulating GPM6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPM6A	tfdimers__MD00018	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SPI1; SPIB; TAF6; TBP (directAnnotation).
GPM6A	transfac_pro__M05939	ZNF471 (directAnnotation).
GPM6A	transfac_public__M00039	CREB1 (directAnnotation).
GPM6A	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
GPM6A	metacluster_179.5	MEF2A; MEF2A; MEF2A; MEF2A (directAnnotation).
GPM6A	transfac_pro__M05447	INSM2 (inferredBy_Orthology).
GPM6A	tfdimers__MD00177	STAT1; TCF7L1 (directAnnotation).
GPM6A	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
GPM6A	tfdimers__MD00550	PITX3; TEAD1 (directAnnotation).
GPM6A	metacluster_4.4	NANOG; NANOG; SOX2; SOX2; SOX2; SOX3; SOX4; SOX4 (directAnnotation). NANOGP8; SOX2 (inferredBy_Orthology).
GPM6A	transfac_pro__M06081	ZNF99 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."