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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ETNK1

Summary for ETNK1

Gene information	Gene symbol	ETNK1
	Ensembl ID	ENSG00000139163
	Entrez ID	55500
	Gene name	ethanolamine kinase 1
	Synonyms	EKI\|EKI1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ETNK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.350093	9.51e-21

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Expression of ETNK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ETNK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ETNK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ETNK1	hsa-miR-15b-5p	88.8026	NM_018638
ETNK1	hsa-miR-15a-5p	88.8026	NM_018638
ETNK1	hsa-miR-5579-3p	88.6489	NM_018638
ETNK1	hsa-miR-4649-3p	88.6232	NM_018638
ETNK1	hsa-miR-600	88.5464	NM_018638
ETNK1	hsa-miR-3975	87.8011	NM_018638
ETNK1	hsa-miR-138-2-3p	87.5081	NM_018638
ETNK1	hsa-miR-6837-3p	87.4674	NM_018638
ETNK1	hsa-miR-4729	87.4483	NM_018638
ETNK1	hsa-miR-5089-5p	87.1108	NM_018638
ETNK1	hsa-miR-3674	86.5649	NM_018638
ETNK1	hsa-miR-374a-5p	86.3808	NM_018638
ETNK1	hsa-miR-6825-5p	86.1578	NM_018638
ETNK1	hsa-miR-7159-5p	86.0998	NM_018638
ETNK1	hsa-miR-4668-5p	85.9001	NM_018638
ETNK1	hsa-miR-6884-5p	85.7779	NM_018638
ETNK1	hsa-miR-485-5p	85.7779	NM_018638
ETNK1	hsa-miR-3148	85.7463	NM_018638
ETNK1	hsa-miR-3913-5p	85.3565	NM_018638
ETNK1	hsa-miR-145-5p	84.5674	NM_018638
ETNK1	hsa-miR-5195-3p	84.5674	NM_018638
ETNK1	hsa-miR-12136	84.3395	NM_018638
ETNK1	hsa-miR-6505-5p	84.0769	NM_018638
ETNK1	hsa-miR-1283	83.9986	NM_018638
ETNK1	hsa-miR-555	83.8126	NM_018638
ETNK1	hsa-miR-3529-3p	83.5654	NM_018638
ETNK1	hsa-miR-4714-5p	83.2379	NM_001039481
ETNK1	hsa-miR-7157-5p	83.2305	NM_018638
ETNK1	hsa-miR-498-5p	82.9766	NM_018638
ETNK1	hsa-miR-1305	82.7538	NM_018638
ETNK1	hsa-miR-4743-3p	82.6336	NM_018638
ETNK1	hsa-miR-216b-3p	82.6168	NM_018638
ETNK1	hsa-miR-8076	82.6014	NM_018638
ETNK1	hsa-miR-489-3p	82.5797	NM_018638
ETNK1	hsa-miR-7-2-3p	82.079	NM_018638
ETNK1	hsa-miR-7-1-3p	82.079	NM_018638
ETNK1	hsa-miR-340-5p	82.0072	NM_018638
ETNK1	hsa-miR-3119	81.7576	NM_018638
ETNK1	hsa-miR-374b-5p	81.6512	NM_018638
ETNK1	hsa-miR-3122	81.4286	NM_018638
ETNK1	hsa-miR-377-3p	81.2607	NM_018638
ETNK1	hsa-miR-6831-3p	81.1379	NM_018638
ETNK1	hsa-miR-6763-5p	81.027	NM_018638
ETNK1	hsa-miR-3150a-3p	81.027	NM_018638
ETNK1	hsa-miR-577	80.9085	NM_018638
ETNK1	hsa-miR-5010-3p	80.8803	NM_018638
ETNK1	hsa-miR-4652-3p	80.4535	NM_018638
ETNK1	hsa-miR-3910	80.1557	NM_018638
ETNK1	hsa-miR-9983-3p	80.0496	NM_018638

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Motifs and transcription factors (TFs) regulating ETNK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ETNK1	metacluster_175.1	ZNF283 (directAnnotation).
ETNK1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ETNK1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ETNK1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."