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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNTN1

Summary for CNTN1

Gene information	Gene symbol	CNTN1
	Ensembl ID	ENSG00000018236
	Entrez ID	1272
	Gene name	contactin 1
	Synonyms	F3\|GP135
	Gene type	protein_coding
	UniProtAcc	Q12860

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Dataset with differentially expressed gene: CNTN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.5305	6.48e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.649346	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.408376	0.00e+00

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Expression of CNTN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNTN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNTN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNTN1	hsa-miR-548aw	86.5631	NM_175038
CNTN1	hsa-miR-429	86.2002	NM_175038
CNTN1	hsa-miR-200b-3p	86.2002	NM_175038
CNTN1	hsa-miR-200c-3p	86.2002	NM_175038
CNTN1	hsa-miR-6885-3p	85.9214	NM_175038
CNTN1	hsa-miR-1272	85.5006	NM_001256064
CNTN1	hsa-miR-5094	85.0063	NM_175038
CNTN1	hsa-miR-12122	84.5337	NM_175038
CNTN1	hsa-miR-4799-5p	84.2067	NM_175038
CNTN1	hsa-miR-6856-3p	83.8267	NM_175038
CNTN1	hsa-miR-1271-5p	83.7186	NM_175038
CNTN1	hsa-miR-12133	83.7186	NM_175038
CNTN1	hsa-miR-12124	83.5371	NM_001256064
CNTN1	hsa-miR-3144-3p	83.3713	NM_175038
CNTN1	hsa-miR-4789-5p	83.2844	NM_001256064
CNTN1	hsa-miR-5582-3p	82.9327	NM_175038
CNTN1	hsa-miR-7856-5p	82.8144	NM_001256064
CNTN1	hsa-miR-4264	82.4468	NM_175038
CNTN1	hsa-miR-6830-3p	82.3161	NM_001256064
CNTN1	hsa-miR-4533	82.102	NM_175038
CNTN1	hsa-miR-8063	81.9273	NM_175038
CNTN1	hsa-miR-556-3p	81.7771	NM_175038
CNTN1	hsa-miR-548at-5p	81.0683	NM_175038
CNTN1	hsa-miR-570-3p	81.061	NM_001256064
CNTN1	hsa-miR-9-3p	81.0362	NM_175038
CNTN1	hsa-miR-374a-5p	80.8217	NM_001256064
CNTN1	hsa-miR-374b-5p	80.8217	NM_001256064
CNTN1	hsa-miR-3163	80.8046	NM_001256064
CNTN1	hsa-miR-5003-5p	80.2903	NM_175038

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Motifs and transcription factors (TFs) regulating CNTN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNTN1	hdpi__NFIX	NFIX (directAnnotation).
CNTN1	transfac_pro__M02843	BBX (inferredBy_Orthology).
CNTN1	metacluster_135.11	NR2C2 (directAnnotation).
CNTN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CNTN1	tfdimers__MD00038	TFAP2C (directAnnotation).
CNTN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CNTN1	cisbp__M00968	MTF2 (directAnnotation).
CNTN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CNTN1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CNTN1	cisbp__M00341	PAX6 (directAnnotation).
CNTN1	metacluster_198.3	ZFP64 (directAnnotation).
CNTN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CNTN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CNTN1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CNTN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CNTN1	cisbp__M00788	ZFY (inferredBy_Orthology).
CNTN1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CNTN1	metacluster_175.1	ZNF283 (directAnnotation).
CNTN1	hdpi__ZNF304	ZNF304 (directAnnotation).
CNTN1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CNTN1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CNTN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CNTN1	transfac_pro__M01199	TRIM28 (directAnnotation).
CNTN1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CNTN1	metacluster_151.2	ZNF23 (directAnnotation).
CNTN1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CNTN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CNTN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
CNTN1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."