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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNOT7

Summary for CNOT7

Gene information	Gene symbol	CNOT7
	Ensembl ID	ENSG00000198791
	Entrez ID	29883
	Gene name	CCR4-NOT transcription complex subunit 7
	Synonyms	CAF1
	Gene type	protein_coding
	UniProtAcc	Q9UIV1

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Dataset with differentially expressed gene: CNOT7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.284431	2.68e-10
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.299488	1.50e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.402064	1.42e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.485749	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.838745	0.00e+00

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Expression of CNOT7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNOT7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNOT7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNOT7	hsa-miR-539-5p	81.8956	NM_001322099
CNOT7	hsa-miR-1290	81.8855	NM_001322094
CNOT7	hsa-miR-12131	81.7387	NM_001322094
CNOT7	hsa-miR-136-5p	81.7312	NM_001322094
CNOT7	hsa-miR-3202	81.7115	NM_013354
CNOT7	hsa-miR-33a-3p	81.702	NM_001322094
CNOT7	hsa-miR-4668-5p	81.609	NM_013354
CNOT7	hsa-miR-320b	80.9426	NM_001322094
CNOT7	hsa-miR-320d	80.9426	NM_001322094
CNOT7	hsa-miR-320c	80.9426	NM_001322094
CNOT7	hsa-miR-320a-3p	80.9426	NM_001322094
CNOT7	hsa-miR-4429	80.9426	NM_001322094
CNOT7	hsa-miR-4699-3p	80.898	NM_001322090
CNOT7	hsa-miR-4713-5p	80.8482	NM_001322099
CNOT7	hsa-miR-320e	80.4666	NM_001322094
CNOT7	hsa-miR-569	80.1763	NM_001322090
CNOT7	hsa-miR-3680-3p	80.1226	NM_001322090

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Motifs and transcription factors (TFs) regulating CNOT7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNOT7	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CNOT7	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CNOT7	transfac_pro__M04944	GABPA (directAnnotation).
CNOT7	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CNOT7	metacluster_81.7	CREB1 (directAnnotation).
CNOT7	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."