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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAMTA1

Summary for CAMTA1

Gene information	Gene symbol	CAMTA1
	Ensembl ID	ENSG00000171735
	Entrez ID	23261
	Gene name	calmodulin binding transcription activator 1
	Synonyms	KIAA0833
	Gene type	protein_coding
	UniProtAcc	Q9Y6Y1

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Dataset with differentially expressed gene: CAMTA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.284032	2.72e-15
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.355189	4.81e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.251524	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.292483	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.300902	9.06e-20
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.260281	4.93e-13
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.302586	6.59e-27
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.444834	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.334283	0.00e+00

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Expression of CAMTA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAMTA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAMTA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAMTA1	hsa-miR-3190-3p	87.3868	NM_015215
CAMTA1	hsa-miR-6855-5p	87.3557	NM_001242701
CAMTA1	hsa-miR-593-5p	87.0653	NM_015215
CAMTA1	hsa-miR-6888-5p	86.7419	NM_015215
CAMTA1	hsa-miR-660-3p	86.7057	NM_015215
CAMTA1	hsa-miR-297	86.642	NM_015215
CAMTA1	hsa-miR-548x-3p	86.5685	NM_015215
CAMTA1	hsa-miR-548aj-3p	86.5685	NM_015215
CAMTA1	hsa-miR-4639-5p	86.5172	NM_015215
CAMTA1	hsa-miR-5589-3p	86.4114	NM_015215
CAMTA1	hsa-miR-6728-3p	86.4065	NM_015215
CAMTA1	hsa-miR-185-3p	86.3417	NM_001242701
CAMTA1	hsa-miR-4999-5p	86.1869	NM_015215
CAMTA1	hsa-miR-4418	86.0245	NM_015215
CAMTA1	hsa-miR-509-5p	86.0245	NM_015215
CAMTA1	hsa-miR-509-3-5p	86.0245	NM_015215
CAMTA1	hsa-miR-676-5p	85.9713	NM_015215
CAMTA1	hsa-miR-4799-5p	85.9471	NM_015215
CAMTA1	hsa-miR-507	85.8787	NM_015215
CAMTA1	hsa-miR-1537-5p	85.8686	NM_015215
CAMTA1	hsa-miR-4718	85.8686	NM_015215
CAMTA1	hsa-miR-1284	85.6467	NM_015215
CAMTA1	hsa-miR-382-3p	85.5995	NM_015215
CAMTA1	hsa-miR-181a-2-3p	85.333	NM_015215
CAMTA1	hsa-miR-3912-5p	85.3078	NM_015215
CAMTA1	hsa-miR-6764-3p	85.2256	NM_015215
CAMTA1	hsa-miR-6824-3p	85.2256	NM_015215
CAMTA1	hsa-miR-6505-5p	85.03	NM_015215
CAMTA1	hsa-miR-4666b	84.7095	NM_015215
CAMTA1	hsa-miR-3170	84.5522	NM_001242701
CAMTA1	hsa-miR-5011-5p	84.2697	NM_015215
CAMTA1	hsa-miR-651-3p	84.1023	NM_015215
CAMTA1	hsa-miR-411-3p	84.0987	NM_015215
CAMTA1	hsa-miR-379-3p	84.0987	NM_015215
CAMTA1	hsa-miR-377-3p	84.0442	NM_015215
CAMTA1	hsa-miR-300	83.8368	NM_015215
CAMTA1	hsa-miR-381-3p	83.8368	NM_015215
CAMTA1	hsa-miR-802	83.4161	NM_001242701
CAMTA1	hsa-miR-548ah-3p	83.3228	NM_015215
CAMTA1	hsa-miR-548ae-3p	83.3228	NM_015215
CAMTA1	hsa-miR-548aq-3p	83.3228	NM_015215
CAMTA1	hsa-miR-548j-3p	83.3228	NM_015215
CAMTA1	hsa-miR-548am-3p	83.3228	NM_015215
CAMTA1	hsa-miR-584-3p	83.2121	NM_015215
CAMTA1	hsa-miR-12122	83.1547	NM_015215
CAMTA1	hsa-miR-4433a-3p	82.986	NM_015215
CAMTA1	hsa-miR-19b-1-5p	82.886	NM_015215
CAMTA1	hsa-miR-19b-2-5p	82.886	NM_015215
CAMTA1	hsa-miR-19a-5p	82.886	NM_015215
CAMTA1	hsa-miR-7856-5p	82.8384	NM_015215

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Motifs and transcription factors (TFs) regulating CAMTA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAMTA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CAMTA1	transfac_pro__M06534	ZNF563 (directAnnotation).
CAMTA1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
CAMTA1	transfac_pro__M06140	ZNF250 (directAnnotation).
CAMTA1	transfac_pro__M06526	ZNF555 (directAnnotation).
CAMTA1	transfac_pro__M05547	PLAGL1 (inferredBy_Orthology).
CAMTA1	transfac_pro__M05298	OVOL3 (directAnnotation).
CAMTA1	transfac_pro__M05540	ZBTB34 (directAnnotation).
CAMTA1	tfdimers__MD00369	ZNF384 (directAnnotation).
CAMTA1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
CAMTA1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CAMTA1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
CAMTA1	transfac_pro__M01783	SP2 (directAnnotation).
CAMTA1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CAMTA1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CAMTA1	cisbp__M00341	PAX6 (directAnnotation).
CAMTA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CAMTA1	transfac_pro__M01253	CNOT3 (directAnnotation).
CAMTA1	metacluster_7.13	ZFX (directAnnotation).
CAMTA1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CAMTA1	cisbp__M00968	MTF2 (directAnnotation).
CAMTA1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CAMTA1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CAMTA1	transfac_pro__M02089	E2F3 (directAnnotation).
CAMTA1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CAMTA1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CAMTA1	metacluster_135.11	NR2C2 (directAnnotation).
CAMTA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CAMTA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CAMTA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CAMTA1	metacluster_198.3	ZFP64 (directAnnotation).
CAMTA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CAMTA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CAMTA1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CAMTA1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CAMTA1	cisbp__M00788	ZFY (inferredBy_Orthology).
CAMTA1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CAMTA1	metacluster_175.1	ZNF283 (directAnnotation).
CAMTA1	hdpi__ZNF304	ZNF304 (directAnnotation).
CAMTA1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CAMTA1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CAMTA1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CAMTA1	transfac_pro__M01199	TRIM28 (directAnnotation).
CAMTA1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CAMTA1	metacluster_151.2	ZNF23 (directAnnotation).
CAMTA1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CAMTA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CAMTA1	transfac_pro__M03806	ZBTB7C (directAnnotation).
CAMTA1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CAMTA1	cisbp__M00249	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."