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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: BMPR2

Summary for BMPR2

Gene information	Gene symbol	BMPR2
	Ensembl ID	ENSG00000204217
	Entrez ID	659
	Gene name	bone morphogenetic protein receptor type 2
	Synonyms	BMPR-II\|BMPR3\|BRK-3\|PPH1\|T-ALK
	Gene type	protein_coding
	UniProtAcc	Q13873

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Dataset with differentially expressed gene: BMPR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.419875	6.35e-37
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.314485	0.00e+00

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Expression of BMPR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BMPR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BMPR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BMPR2	hsa-miR-301a-3p	85.0672	NM_001204
BMPR2	hsa-miR-4666a-3p	85.0659	NM_001204
BMPR2	hsa-miR-1250-3p	85.0074	NM_001204
BMPR2	hsa-miR-100-3p	84.9799	NM_001204
BMPR2	hsa-miR-6124	84.5961	NM_001204
BMPR2	hsa-miR-10399-5p	84.4608	NM_001204
BMPR2	hsa-miR-551b-5p	84.3074	NM_001204
BMPR2	hsa-miR-300	84.1863	NM_001204
BMPR2	hsa-miR-381-3p	84.1863	NM_001204
BMPR2	hsa-miR-3912-5p	83.5884	NM_001204
BMPR2	hsa-miR-4684-3p	83.4389	NM_001204
BMPR2	hsa-miR-32-5p	83.3587	NM_001204
BMPR2	hsa-miR-92a-3p	83.3587	NM_001204
BMPR2	hsa-miR-92b-3p	83.3587	NM_001204
BMPR2	hsa-miR-3920	83.2456	NM_001204
BMPR2	hsa-miR-577	82.925	NM_001204
BMPR2	hsa-miR-6077	82.826	NM_001204
BMPR2	hsa-miR-7108-5p	82.806	NM_001204
BMPR2	hsa-miR-6864-3p	82.7515	NM_001204
BMPR2	hsa-miR-3672	82.7515	NM_001204
BMPR2	hsa-miR-5093	82.6995	NM_001204
BMPR2	hsa-miR-6507-5p	82.5247	NM_001204
BMPR2	hsa-miR-192-3p	82.4371	NM_001204
BMPR2	hsa-miR-20a-3p	82.1862	NM_001204
BMPR2	hsa-miR-4477b	81.8718	NM_001204
BMPR2	hsa-miR-1283	81.7913	NM_001204
BMPR2	hsa-miR-302a-5p	81.6294	NM_001204
BMPR2	hsa-miR-486-3p	81.4849	NM_001204
BMPR2	hsa-miR-363-3p	81.4135	NM_001204
BMPR2	hsa-miR-25-3p	81.4135	NM_001204
BMPR2	hsa-miR-367-3p	81.4135	NM_001204
BMPR2	hsa-miR-4801	81.0165	NM_001204
BMPR2	hsa-miR-4731-3p	81.0165	NM_001204
BMPR2	hsa-miR-7850-5p	80.8568	NM_001204
BMPR2	hsa-miR-4646-3p	80.4288	NM_001204
BMPR2	hsa-miR-10522-5p	80.2578	NM_001204

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Motifs and transcription factors (TFs) regulating BMPR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BMPR2	metacluster_151.2	ZNF23 (directAnnotation).
BMPR2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BMPR2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BMPR2	jaspar__MA0748.2	YY2 (directAnnotation).
BMPR2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
BMPR2	"Dibotermin alfa"	DB11639	biotech
BMPR2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."