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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ASPH

Summary for ASPH

Gene information	Gene symbol	ASPH
	Ensembl ID	ENSG00000198363
	Entrez ID	444
	Gene name	aspartate beta-hydroxylase
	Synonyms	BAH\|CASQ2BP1\|HAAH\|JCTN
	Gene type	protein_coding
	UniProtAcc	Q12797

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Dataset with differentially expressed gene: ASPH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.813615	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.287955	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.53156	7.14e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.398978	1.38e-06
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.88389	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.392664	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.256016	7.83e-09
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.256561	0.00e+00

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Expression of ASPH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASPH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASPH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASPH	hsa-miR-629-5p	81.7619	NM_001164750
ASPH	hsa-miR-92b-3p	81.7131	NM_001164753
ASPH	hsa-miR-32-5p	81.7131	NM_001164753
ASPH	hsa-miR-92a-3p	81.7131	NM_001164753
ASPH	hsa-miR-4769-5p	81.6839	NM_001164750
ASPH	hsa-miR-4491	81.6725	NM_001164750
ASPH	hsa-miR-4657	81.6725	NM_001164750
ASPH	hsa-miR-4451	81.6281	NM_001164750
ASPH	hsa-miR-5010-3p	81.3476	NM_001164750
ASPH	hsa-miR-1225-5p	81.3447	NM_001164753
ASPH	hsa-miR-589-5p	81.0601	NM_001164750
ASPH	hsa-miR-6759-5p	81.0008	NM_001164750
ASPH	hsa-miR-4704-5p	80.7658	NM_001164750
ASPH	hsa-miR-6780a-3p	80.6823	NM_001164750
ASPH	hsa-miR-342-3p	80.6483	NM_001164753
ASPH	hsa-miR-3059-5p	80.5261	NM_001164750
ASPH	hsa-miR-891a-3p	80.4595	NM_020164
ASPH	hsa-miR-3681-3p	80.4312	NM_001164750
ASPH	hsa-miR-137-3p	80.4156	NM_001164753
ASPH	hsa-miR-7113-5p	80.3542	NM_001164753
ASPH	hsa-miR-515-5p	80.219	NM_020164
ASPH	hsa-miR-519e-5p	80.219	NM_020164
ASPH	hsa-miR-6073	80.1177	NM_001164750

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Motifs and transcription factors (TFs) regulating ASPH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASPH	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ASPH	metacluster_151.2	ZNF23 (directAnnotation).
ASPH	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ASPH	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ASPH	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ASPH	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ASPH	jaspar__MA0079.5	SP1 (directAnnotation).
ASPH	metacluster_107.2	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
ASPH	metacluster_107.1	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
ASPH	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
ASPH	transfac_pro__M05521	ZNF398 (directAnnotation).
ASPH	metacluster_72.10	ZNF697 (directAnnotation).
ASPH	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
ASPH	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
ASPH	transfac_pro__M06564	ZNF578 (directAnnotation).
ASPH	jaspar__MA1948.1	ETV5 (directAnnotation).
ASPH	transfac_pro__M05858	ZNF625 (directAnnotation).
ASPH	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
ASPH	transfac_pro__M06372	ZNF841 (directAnnotation).
ASPH	kznf__ZNF792_Imbeault2017_OM_MEME	ZNF792 (directAnnotation).
ASPH	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
ASPH	transfac_pro__M06277	ZNF404 (directAnnotation).
ASPH	transfac_pro__M06642	ZSCAN10 (directAnnotation).
ASPH	transfac_pro__M04826	EP300 (directAnnotation).
ASPH	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ASPH	jaspar__MA1933.1	SREBF2 (directAnnotation).
ASPH	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
ASPH	transfac_pro__M00652	NRF1 (directAnnotation).
ASPH	transfac_pro__M04918	EGR1 (directAnnotation).
ASPH	hdpi__TP73	TP73 (directAnnotation).
ASPH	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
ASPH	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ASPH	transfac_pro__M04794	TAF1 (directAnnotation).
ASPH	transfac_pro__M04862	NRF1 (directAnnotation).
ASPH	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ASPH	jaspar__MA0748.2	YY2 (directAnnotation).
ASPH	transfac_pro__M01298	MECP2 (directAnnotation).
ASPH	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
ASPH	metacluster_182.10	ZFX (directAnnotation).
ASPH	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ASPH	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
ASPH	metacluster_22.34	BACH2 (directAnnotation).
ASPH	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
ASPH	metacluster_22.37	BACH1 (directAnnotation).
ASPH	metacluster_22.13	MAFK (inferredBy_Orthology).
ASPH	metacluster_22.18	BACH2 (inferredBy_Orthology).
ASPH	transfac_pro__M06181	ZNF165 (directAnnotation).
ASPH	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
ASPH	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
ASPH	metacluster_22.32	NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ASPH	"Aspartic acid"	DB00128	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."