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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARID2

Summary for ARID2

Gene information	Gene symbol	ARID2
	Ensembl ID	ENSG00000189079
	Entrez ID	196528
	Gene name	AT-rich interaction domain 2
	Synonyms	BAF200\|DKFZp686G052\|FLJ30619\|KIAA1557\|SMARCF3
	Gene type	protein_coding
	UniProtAcc	Q68CP9

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Dataset with differentially expressed gene: ARID2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.263055	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.269381	0.00e+00

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Expression of ARID2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARID2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARID2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARID2	hsa-miR-885-5p	86.5711	NM_152641
ARID2	hsa-miR-7106-5p	86.4654	NM_152641
ARID2	hsa-miR-2682-5p	86.2499	NM_152641
ARID2	hsa-miR-627-3p	85.728	NM_152641
ARID2	hsa-miR-4793-5p	85.6375	NM_152641
ARID2	hsa-miR-1277-5p	85.5857	NM_152641
ARID2	hsa-miR-138-2-3p	85.5718	NM_152641
ARID2	hsa-miR-153-5p	85.1981	NM_152641
ARID2	hsa-miR-329-5p	84.5932	NM_152641
ARID2	hsa-miR-4799-5p	84.388	NM_152641
ARID2	hsa-miR-6739-3p	83.7974	NM_152641
ARID2	hsa-miR-5693	83.5223	NM_152641
ARID2	hsa-miR-1193	83.5104	NM_152641
ARID2	hsa-miR-2115-3p	83.4618	NM_152641
ARID2	hsa-miR-4680-3p	83.0156	NM_152641
ARID2	hsa-miR-6715a-3p	82.6093	NM_152641
ARID2	hsa-miR-513b-5p	82.2733	NM_152641
ARID2	hsa-miR-767-3p	82.006	NM_152641
ARID2	hsa-miR-4653-5p	81.9049	NM_152641
ARID2	hsa-miR-3921	81.9049	NM_152641
ARID2	hsa-miR-6715b-3p	81.7077	NM_152641
ARID2	hsa-miR-3691-5p	81.4462	NM_152641
ARID2	hsa-miR-6073	81.3529	NM_152641
ARID2	hsa-miR-452-3p	81.0948	NM_152641
ARID2	hsa-miR-1298-5p	81.0783	NM_152641
ARID2	hsa-miR-3160-5p	81.0369	NM_152641
ARID2	hsa-miR-338-5p	80.9708	NM_152641
ARID2	hsa-miR-6508-5p	80.9481	NM_152641
ARID2	hsa-miR-27b-5p	80.7533	NM_152641
ARID2	hsa-miR-625-5p	80.4952	NM_152641
ARID2	hsa-miR-194-5p	80.3672	NM_152641
ARID2	hsa-miR-649	80.184	NM_152641
ARID2	hsa-miR-4490	80.0374	NM_152641

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Motifs and transcription factors (TFs) regulating ARID2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARID2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ARID2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARID2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARID2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ARID2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARID2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ARID2	jaspar__MA1721.1	ZNF93 (directAnnotation).
ARID2	metacluster_151.2	ZNF23 (directAnnotation).
ARID2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARID2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ARID2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ARID2	transfac_pro__M01199	TRIM28 (directAnnotation).
ARID2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARID2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ARID2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ARID2	transfac_pro__M01253	CNOT3 (directAnnotation).
ARID2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ARID2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ARID2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ARID2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ARID2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ARID2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ARID2	cisbp__M00968	MTF2 (directAnnotation).
ARID2	jaspar__MA0748.2	YY2 (directAnnotation).
ARID2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARID2	metacluster_7.13	ZFX (directAnnotation).
ARID2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ARID2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARID2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ARID2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ARID2	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ARID2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ARID2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ARID2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARID2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ARID2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ARID2	transfac_pro__M07310	SP5 (directAnnotation).
ARID2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARID2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ARID2	transfac_pro__M00938	E2F1 (directAnnotation).
ARID2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARID2	transfac_pro__M04893	TAF1 (directAnnotation).
ARID2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARID2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ARID2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ARID2	transfac_pro__M12697	ZNF142 (directAnnotation).
ARID2	metacluster_175.1	ZNF283 (directAnnotation).
ARID2	cisbp__M00788	ZFY (inferredBy_Orthology).
ARID2	tfdimers__MD00364	WT1 (directAnnotation).
ARID2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."