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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AGO1

Summary for AGO1

Gene information	Gene symbol	AGO1
	Ensembl ID	ENSG00000092847
	Entrez ID	26523
	Gene name	argonaute RISC component 1
	Synonyms	EIF2C1\|hAGO1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AGO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.304491	0.00e+00

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Expression of AGO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AGO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AGO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AGO1	hsa-miR-4667-3p	83.9859	NM_001317123
AGO1	hsa-miR-6754-5p	83.9244	NM_001317123
AGO1	hsa-miR-5009-3p	83.6959	NM_001317123
AGO1	hsa-miR-132-3p	83.6321	NM_001317123
AGO1	hsa-miR-212-3p	83.6321	NM_001317123
AGO1	hsa-miR-6875-3p	83.6316	NM_001317123
AGO1	hsa-miR-4447	83.5848	NM_001317123
AGO1	hsa-miR-605-3p	83.2274	NM_001317122
AGO1	hsa-miR-92a-2-5p	83.19	NM_001317122
AGO1	hsa-miR-1207-3p	83.1739	NM_001317123
AGO1	hsa-miR-2467-3p	83.1049	NM_001317123
AGO1	hsa-miR-11181-3p	83.0507	NM_001317122
AGO1	hsa-miR-10394-5p	83.0306	NM_001317123
AGO1	hsa-miR-1205	83.0306	NM_001317123
AGO1	hsa-miR-16-5p	82.9529	NM_001317123
AGO1	hsa-miR-15a-5p	82.9529	NM_001317123
AGO1	hsa-miR-15b-5p	82.9529	NM_001317123
AGO1	hsa-miR-195-5p	82.9529	NM_001317123
AGO1	hsa-miR-424-5p	82.9529	NM_001317123
AGO1	hsa-miR-497-5p	82.9529	NM_001317123
AGO1	hsa-miR-6838-5p	82.9529	NM_001317123
AGO1	hsa-miR-3125	82.8821	NM_001317122
AGO1	hsa-miR-3678-3p	82.7252	NM_001317123
AGO1	hsa-miR-513c-5p	82.7222	NM_001317123
AGO1	hsa-miR-514b-5p	82.7222	NM_001317123
AGO1	hsa-miR-6842-3p	82.6355	NM_001317123
AGO1	hsa-miR-185-5p	82.6209	NM_001317122
AGO1	hsa-miR-3652	82.6202	NM_001317123
AGO1	hsa-miR-302a-5p	82.403	NM_001317122
AGO1	hsa-miR-2355-5p	82.1285	NM_001317123
AGO1	hsa-miR-153-3p	81.8793	NM_001317123
AGO1	hsa-miR-651-3p	81.777	NM_001317123
AGO1	hsa-miR-216a-5p	81.6149	NM_001317122
AGO1	hsa-miR-6825-5p	81.1241	NM_001317122
AGO1	hsa-miR-19a-5p	80.9408	NM_001317123
AGO1	hsa-miR-19b-2-5p	80.9408	NM_001317123
AGO1	hsa-miR-19b-1-5p	80.9408	NM_001317123
AGO1	hsa-miR-371a-3p	80.8087	NM_001317123
AGO1	hsa-miR-6730-5p	80.6252	NM_001317122
AGO1	hsa-miR-486-3p	80.5903	NM_001317122
AGO1	hsa-miR-2052	80.5158	NM_001317123
AGO1	hsa-miR-4695-5p	80.4602	NM_001317122
AGO1	hsa-miR-432-5p	80.3852	NM_001317122
AGO1	hsa-miR-3916	80.2618	NM_001317122
AGO1	hsa-miR-4753-5p	80.2577	NM_001317122
AGO1	hsa-miR-2113	80.1663	NM_001317123

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Motifs and transcription factors (TFs) regulating AGO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AGO1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AGO1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
AGO1	transfac_pro__M01973	PLAG1 (directAnnotation).
AGO1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
AGO1	taipale_tf_pairs__TFAP2C_ELK1_NGCCTNNGGSNNCGGAAGYN_CAP_repr	ELK1; TFAP2C (directAnnotation).
AGO1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
AGO1	transfac_pro__M06510	ZFP62 (directAnnotation).
AGO1	transfac_pro__M05523	ZBTB46 (directAnnotation).
AGO1	transfac_pro__M05501	ZBTB8B (directAnnotation).
AGO1	taipale_tf_pairs__FLI1_CEBPB_RNCGGANNTTGCGCAAN_CAP	CEBPB; FLI1 (directAnnotation).
AGO1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AGO1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AGO1	transfac_pro__M06083	ZNF891 (directAnnotation).
AGO1	metacluster_81.4	FOXN1; FOXN1; FOXN2; FOXN4; FOXR1; PROX1; PROX1 (directAnnotation). FOXN1; FOXN4 (inferredBy_Orthology).
AGO1	transfac_pro__M06568	ZNF501 (directAnnotation).
AGO1	transfac_pro__M04861	SIX5 (directAnnotation).
AGO1	transfac_pro__M06592	ZNF486 (directAnnotation).
AGO1	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
AGO1	swissregulon__mm__Stat4	STAT4 (inferredBy_Orthology).
AGO1	transfac_pro__M05617	ZNF500 (directAnnotation).
AGO1	transfac_pro__M06045	ZNF729 (directAnnotation).
AGO1	swissregulon__hs__ZNF8	ZNF8 (directAnnotation).
AGO1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."