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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AEBP2

Summary for AEBP2

Gene information	Gene symbol	AEBP2
	Ensembl ID	ENSG00000139154
	Entrez ID	121536
	Gene name	AE binding protein 2
	Synonyms	MGC17922
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AEBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.276283	9.25e-17

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Expression of AEBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AEBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AEBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AEBP2	hsa-miR-12136	83.6967	NM_001114176
AEBP2	hsa-miR-1537-3p	83.2736	NM_153207
AEBP2	hsa-miR-6868-5p	83.243	NM_153207
AEBP2	hsa-miR-132-3p	82.3606	NM_001114176
AEBP2	hsa-miR-135b-5p	82.3203	NM_001114176
AEBP2	hsa-miR-135a-5p	82.3203	NM_001114176
AEBP2	hsa-miR-4762-5p	81.7147	NM_001114176
AEBP2	hsa-miR-548ay-3p	81.6957	NM_153207
AEBP2	hsa-miR-548at-3p	81.6957	NM_153207
AEBP2	hsa-miR-2116-5p	81.6615	NM_001114176
AEBP2	hsa-miR-4735-3p	81.5081	NM_153207
AEBP2	hsa-miR-18b-5p	81.5081	NM_153207
AEBP2	hsa-miR-18a-5p	81.5081	NM_153207
AEBP2	hsa-miR-5701	81.2465	NM_001114176
AEBP2	hsa-miR-451b	81.1749	NM_001114176
AEBP2	hsa-miR-6798-3p	81.0643	NM_001114176
AEBP2	hsa-miR-12133	81.0408	NM_153207
AEBP2	hsa-miR-1271-5p	81.0408	NM_153207
AEBP2	hsa-miR-1252-3p	80.4164	NM_001114176
AEBP2	hsa-miR-7-2-3p	80.3409	NM_001114176
AEBP2	hsa-miR-7-1-3p	80.3409	NM_001114176
AEBP2	hsa-miR-204-5p	80.0996	NM_001114176
AEBP2	hsa-miR-211-5p	80.0996	NM_001114176
AEBP2	hsa-miR-4772-3p	80.0178	NM_153207

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Motifs and transcription factors (TFs) regulating AEBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AEBP2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."