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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ACVR2B

Summary for ACVR2B

Gene information	Gene symbol	ACVR2B
	Ensembl ID	ENSG00000114739
	Entrez ID	93
	Gene name	activin A receptor type 2B
	Synonyms	ActR-IIB
	Gene type	protein_coding
	UniProtAcc	Q13705

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Dataset with differentially expressed gene: ACVR2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.257397	0.00e+00

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Expression of ACVR2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACVR2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACVR2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACVR2B	hsa-miR-26b-3p	86.8136	NM_001106
ACVR2B	hsa-miR-217-5p	86.7049	NM_001106
ACVR2B	hsa-miR-12122	86.445	NM_001106
ACVR2B	hsa-miR-599	86.2491	NM_001106
ACVR2B	hsa-miR-6807-3p	85.9799	NM_001106
ACVR2B	hsa-miR-8068	85.5426	NM_001106
ACVR2B	hsa-miR-199b-3p	85.141	NM_001106
ACVR2B	hsa-miR-199a-3p	85.141	NM_001106
ACVR2B	hsa-miR-3129-5p	85.141	NM_001106
ACVR2B	hsa-miR-6727-3p	84.798	NM_001106
ACVR2B	hsa-miR-3189-3p	84.4489	NM_001106
ACVR2B	hsa-miR-2467-5p	84.4442	NM_001106
ACVR2B	hsa-miR-5692a	84.3201	NM_001106
ACVR2B	hsa-miR-324-3p	84.2827	NM_001106
ACVR2B	hsa-miR-3664-5p	84.2489	NM_001106
ACVR2B	hsa-miR-3692-5p	84.1995	NM_001106
ACVR2B	hsa-miR-561-3p	84.1954	NM_001106
ACVR2B	hsa-miR-6793-3p	84.1004	NM_001106
ACVR2B	hsa-miR-4666a-3p	83.8727	NM_001106
ACVR2B	hsa-miR-195-5p	83.6807	NM_001106
ACVR2B	hsa-miR-16-5p	83.6807	NM_001106
ACVR2B	hsa-miR-15a-5p	83.6807	NM_001106
ACVR2B	hsa-miR-15b-5p	83.6807	NM_001106
ACVR2B	hsa-miR-4491	83.5855	NM_001106
ACVR2B	hsa-miR-6826-3p	83.501	NM_001106
ACVR2B	hsa-miR-597-5p	83.4818	NM_001106
ACVR2B	hsa-miR-5704	83.4242	NM_001106
ACVR2B	hsa-miR-138-5p	83.4074	NM_001106
ACVR2B	hsa-miR-4649-3p	83.3016	NM_001106
ACVR2B	hsa-miR-4310	82.9022	NM_001106
ACVR2B	hsa-miR-4288	82.4842	NM_001106
ACVR2B	hsa-miR-4426	82.4808	NM_001106
ACVR2B	hsa-miR-6838-5p	82.3676	NM_001106
ACVR2B	hsa-miR-3916	82.2518	NM_001106
ACVR2B	hsa-miR-6859-5p	82.2518	NM_001106
ACVR2B	hsa-miR-3125	82.2518	NM_001106
ACVR2B	hsa-miR-6512-5p	82.0967	NM_001106
ACVR2B	hsa-miR-4476	82.0067	NM_001106
ACVR2B	hsa-miR-6876-5p	82.0067	NM_001106
ACVR2B	hsa-miR-6131	81.8342	NM_001106
ACVR2B	hsa-miR-126-5p	81.8336	NM_001106
ACVR2B	hsa-miR-2053	81.8008	NM_001106
ACVR2B	hsa-miR-6844	81.6869	NM_001106
ACVR2B	hsa-miR-6817-5p	81.6049	NM_001106
ACVR2B	hsa-miR-4769-3p	81.6049	NM_001106
ACVR2B	hsa-miR-6828-5p	81.4503	NM_001106
ACVR2B	hsa-miR-409-5p	81.1381	NM_001106
ACVR2B	hsa-miR-4646-5p	81.1181	NM_001106
ACVR2B	hsa-miR-5000-3p	81.1086	NM_001106
ACVR2B	hsa-miR-3670	80.9951	NM_001106

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Motifs and transcription factors (TFs) regulating ACVR2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACVR2B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ACVR2B	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."