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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF800

Summary for ZNF800

Gene information	Gene symbol	ZNF800
	Ensembl ID	ENSG00000048405
	Entrez ID	168850
	Gene name	zinc finger protein 800
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q2TB10

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Dataset with differentially expressed gene: ZNF800

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.493167	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.38184	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.298313	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.288336	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.378888	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.335783	2.01e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.310146	3.10e-42

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Expression of ZNF800 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF800

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF800

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF800	hsa-miR-568	92.6718	NM_176814
ZNF800	hsa-miR-4724-3p	92.2653	NM_176814
ZNF800	hsa-miR-8054	92.046	NM_176814
ZNF800	hsa-miR-548k	92.046	NM_176814
ZNF800	hsa-miR-548av-5p	92.046	NM_176814
ZNF800	hsa-miR-6824-5p	91.7516	NM_176814
ZNF800	hsa-miR-381-3p	91.592	NM_176814
ZNF800	hsa-miR-300	91.592	NM_176814
ZNF800	hsa-miR-548ah-5p	91.5188	NM_176814
ZNF800	hsa-miR-3609	91.5188	NM_176814
ZNF800	hsa-miR-1276	91.4418	NM_176814
ZNF800	hsa-miR-3938	91.2807	NM_176814
ZNF800	hsa-miR-205-5p	91.2143	NM_176814
ZNF800	hsa-miR-1245b-3p	90.4064	NM_176814
ZNF800	hsa-miR-216a-3p	89.9628	NM_176814
ZNF800	hsa-miR-128-3p	89.9628	NM_176814
ZNF800	hsa-miR-3065-5p	89.6122	NM_176814
ZNF800	hsa-miR-454-3p	89.4711	NM_176814
ZNF800	hsa-miR-513a-5p	89.1246	NM_176814
ZNF800	hsa-miR-3681-3p	88.8695	NM_176814
ZNF800	hsa-miR-3646	88.6544	NM_176814
ZNF800	hsa-miR-583	88.2987	NM_176814
ZNF800	hsa-miR-548ac	88.2588	NM_176814
ZNF800	hsa-miR-548d-3p	88.2588	NM_176814
ZNF800	hsa-miR-548h-3p	88.2588	NM_176814
ZNF800	hsa-miR-548bb-3p	88.2588	NM_176814
ZNF800	hsa-miR-548z	88.2588	NM_176814
ZNF800	hsa-miR-1305	88.111	NM_176814
ZNF800	hsa-miR-744-3p	88.0761	NM_176814
ZNF800	hsa-miR-6878-5p	87.8494	NM_176814
ZNF800	hsa-miR-8069	87.6032	NM_176814
ZNF800	hsa-miR-122b-3p	87.4011	NM_176814
ZNF800	hsa-miR-21-3p	87.4011	NM_176814
ZNF800	hsa-miR-613	87.115	NM_176814
ZNF800	hsa-miR-1-3p	87.115	NM_176814
ZNF800	hsa-miR-206	87.115	NM_176814
ZNF800	hsa-miR-514b-3p	86.5767	NM_176814
ZNF800	hsa-miR-514a-3p	86.5767	NM_176814
ZNF800	hsa-miR-130b-3p	86.3773	NM_176814
ZNF800	hsa-miR-301a-3p	86.3773	NM_176814
ZNF800	hsa-miR-301b-3p	86.3773	NM_176814
ZNF800	hsa-miR-130a-3p	86.3773	NM_176814
ZNF800	hsa-miR-3666	86.3773	NM_176814
ZNF800	hsa-miR-4295	86.3773	NM_176814
ZNF800	hsa-miR-548x-3p	85.7356	NM_176814
ZNF800	hsa-miR-548aj-3p	85.7356	NM_176814
ZNF800	hsa-miR-590-3p	85.3651	NM_176814
ZNF800	hsa-miR-6830-3p	85.0439	NM_176814
ZNF800	hsa-miR-6783-5p	84.9961	NM_176814
ZNF800	hsa-miR-670-3p	84.993	NM_176814

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Motifs and transcription factors (TFs) regulating ZNF800

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF800	metacluster_151.2	ZNF23 (directAnnotation).
ZNF800	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ZNF800	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZNF800	hdpi__ETV4	ETV4 (directAnnotation).
ZNF800	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZNF800	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
ZNF800	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ZNF800	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZNF800	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZNF800	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZNF800	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZNF800	transfac_pro__M04893	TAF1 (directAnnotation).
ZNF800	transfac_pro__M01199	TRIM28 (directAnnotation).
ZNF800	hdpi__TP73	TP73 (directAnnotation).
ZNF800	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZNF800	hdpi__HIP2	UBE2K (directAnnotation).
ZNF800	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZNF800	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZNF800	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZNF800	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZNF800	transfac_pro__M00938	E2F1 (directAnnotation).
ZNF800	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ZNF800	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZNF800	hdpi__RARA	RARA (directAnnotation).
ZNF800	hdpi__ELF2	ELF2 (directAnnotation).
ZNF800	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ZNF800	cisbp__M00968	MTF2 (directAnnotation).
ZNF800	transfac_pro__M02898	SMAD3 (directAnnotation).
ZNF800	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZNF800	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ZNF800	jaspar__MA1721.1	ZNF93 (directAnnotation).
ZNF800	transfac_pro__M04916	TAF1 (directAnnotation).
ZNF800	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF800	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZNF800	transfac_pro__M07310	SP5 (directAnnotation).
ZNF800	cisbp__M00788	ZFY (inferredBy_Orthology).
ZNF800	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZNF800	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ZNF800	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF800	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZNF800	hdpi__ZNF304	ZNF304 (directAnnotation).
ZNF800	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ZNF800	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ZNF800	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZNF800	metacluster_101.3	MYB (directAnnotation).
ZNF800	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZNF800	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZNF800	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZNF800	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF800	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."