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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF521

Summary for ZNF521

Gene information	Gene symbol	ZNF521
	Ensembl ID	ENSG00000198795
	Entrez ID	25925
	Gene name	zinc finger protein 521
	Synonyms	EHZF\|Evi3
	Gene type	protein_coding
	UniProtAcc	Q96K83

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Dataset with differentially expressed gene: ZNF521

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Fibroblasts	-0.473931	3.04e-04

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Expression of ZNF521 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF521

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF521

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF521	hsa-miR-145-5p	84.952	NM_001308225
ZNF521	hsa-miR-6515-3p	84.5169	NM_001308225
ZNF521	hsa-miR-4311	84.2149	NM_001308225
ZNF521	hsa-miR-323a-3p	84.1556	NM_001308225
ZNF521	hsa-miR-6882-5p	83.8943	NM_001308225
ZNF521	hsa-miR-1296-5p	83.6685	NM_001308225
ZNF521	hsa-miR-26b-3p	83.2668	NM_001308225
ZNF521	hsa-miR-4680-3p	83.1727	NM_001308225
ZNF521	hsa-miR-1277-5p	82.9618	NM_001308225
ZNF521	hsa-miR-6895-5p	81.5748	NM_001308225
ZNF521	hsa-miR-4512	81.5748	NM_001308225
ZNF521	hsa-miR-338-5p	81.5616	NM_001308225
ZNF521	hsa-miR-6124	81.4816	NM_001308225
ZNF521	hsa-miR-5195-3p	81.1153	NM_001308225

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Motifs and transcription factors (TFs) regulating ZNF521

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF521	dbtfbs__ZBED5_HepG2_ENCSR656SIB_merged_N1	ZBED5 (directAnnotation).
ZNF521	transfac_pro__M05951	ZNF672 (inferredBy_Orthology).
ZNF521	metacluster_134.5	ZNF184 (directAnnotation).
ZNF521	transfac_pro__M06070	ZNF732 (directAnnotation).
ZNF521	transfac_pro__M06027	ZNF891 (directAnnotation).
ZNF521	metacluster_198.3	ZFP64 (directAnnotation).
ZNF521	kznf__ZNF786_Imbeault2017_RP_ChIP-seq	ZNF786 (directAnnotation).
ZNF521	metacluster_143.13	ZBTB7A (directAnnotation).
ZNF521	metacluster_67.1	ZFP64 (directAnnotation).
ZNF521	metacluster_172.30	BDP1; BRF1; ZNF354B (directAnnotation). ZNF354A (inferredBy_Orthology).
ZNF521	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
ZNF521	transfac_pro__M05479	ZNF580 (directAnnotation).
ZNF521	metacluster_135.11	NR2C2 (directAnnotation).
ZNF521	dbtfbs__HIC1_HEK293_ENCSR803GYT_merged_N1	HIC1 (directAnnotation).
ZNF521	metacluster_182.5	HINFP (directAnnotation).
ZNF521	jaspar__MA0131.2	HINFP (directAnnotation).
ZNF521	transfac_pro__M07387	ZBTB7A (directAnnotation).
ZNF521	transfac_pro__M06789	ZNF835 (directAnnotation).
ZNF521	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZNF521	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ZNF521	taipale_tf_pairs__ETV2_PAX5_ACCGGANNTACGCNNNNNYR_CAP	ETV2; PAX5 (directAnnotation).
ZNF521	transfac_pro__M06894	ZFP90 (inferredBy_Orthology).
ZNF521	taipale_tf_pairs__ETV2_SOX15_RSCGGAWNNNNNNNACAATRN_CAP_repr	ETV2; SOX15 (directAnnotation).
ZNF521	transfac_pro__M05482	ZNF202 (directAnnotation).
ZNF521	jaspar__MA0163.1	PLAG1 (directAnnotation).
ZNF521	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ZNF521	transfac_pro__M06516	ZNF418 (directAnnotation).
ZNF521	transfac_pro__M01303	SP1 (directAnnotation).
ZNF521	transfac_pro__M05432	ZSCAN18 (directAnnotation).
ZNF521	metacluster_3.14	WT1; WT1 (directAnnotation).
ZNF521	transfac_pro__M00986	CHURC1 (directAnnotation).
ZNF521	transfac_pro__M01152	NR1I2; RXRA (directAnnotation).
ZNF521	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ZNF521	taipale_tf_pairs__HOXB2_HOXB13_NNMATCACATAAAN_CAP_repr	HOXB13; HOXB2 (directAnnotation).
ZNF521	transfac_pro__M06950	HIF3A (inferredBy_Orthology).
ZNF521	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ZNF521	transfac_pro__M05700	ZNF19 (directAnnotation).
ZNF521	transfac_pro__M01253	CNOT3 (directAnnotation).
ZNF521	transfac_pro__M04817	ZBTB33 (directAnnotation).
ZNF521	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ZNF521	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZNF521	metacluster_155.18	ZNF350; ZNF674; ZNF674 (directAnnotation).
ZNF521	transfac_pro__M06463	ZNF595 (directAnnotation).
ZNF521	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
ZNF521	tfdimers__MD00148	CHURC1; ZBTB7A (directAnnotation).
ZNF521	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ZNF521	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ZNF521	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ZNF521	transfac_pro__M07436	WT1 (directAnnotation).
ZNF521	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."