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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF326

Summary for ZNF326

Gene information	Gene symbol	ZNF326
	Ensembl ID	ENSG00000162664
	Entrez ID	284695
	Gene name	zinc finger protein 326
	Synonyms	FLJ20403\|ZAN75\|Zfp326\|ZIRD
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZNF326

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.319267	2.20e-11
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.399074	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.424779	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.37922	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.345565	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.407631	0.00e+00

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Expression of ZNF326 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF326

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF326

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF326	hsa-miR-548i	92.0329	NM_181781
ZNF326	hsa-miR-548ae-5p	92.0329	NM_181781
ZNF326	hsa-miR-548au-5p	92.0329	NM_181781
ZNF326	hsa-miR-6513-5p	91.6352	NM_181781
ZNF326	hsa-miR-130b-5p	91.5619	NM_001320185
ZNF326	hsa-miR-664b-3p	90.5205	NM_001320185
ZNF326	hsa-miR-7159-5p	90.4534	NM_181781
ZNF326	hsa-miR-10527-5p	90.2874	NM_182975
ZNF326	hsa-miR-4760-3p	90.0618	NM_001320185
ZNF326	hsa-miR-12136	89.9399	NM_001320185
ZNF326	hsa-miR-4703-3p	89.6433	NM_182975
ZNF326	hsa-miR-8080	89.2295	NM_181781
ZNF326	hsa-miR-5696	88.8678	NM_001320185
ZNF326	hsa-miR-187-5p	88.7131	NM_001320185
ZNF326	hsa-miR-548c-3p	88.4016	NM_001320185
ZNF326	hsa-miR-130a-5p	88.1646	NM_001320185
ZNF326	hsa-miR-429	87.718	NM_182975
ZNF326	hsa-miR-200c-3p	87.718	NM_182975
ZNF326	hsa-miR-200b-3p	87.718	NM_182975
ZNF326	hsa-miR-3153	87.4999	NM_181781
ZNF326	hsa-miR-670-3p	87.4331	NM_181781
ZNF326	hsa-miR-142-5p	87.3885	NM_181781
ZNF326	hsa-miR-3163	87.1667	NM_001320185
ZNF326	hsa-miR-6083	86.7893	NM_182975
ZNF326	hsa-miR-6074	85.9698	NM_001320185
ZNF326	hsa-miR-6128	85.7663	NM_181781
ZNF326	hsa-miR-3194-3p	85.7003	NM_181781
ZNF326	hsa-miR-660-5p	85.5997	NM_182975
ZNF326	hsa-miR-323a-3p	85.588	NM_182975
ZNF326	hsa-miR-590-3p	85.5581	NM_181781
ZNF326	hsa-miR-3059-5p	85.5412	NM_181781
ZNF326	hsa-miR-124-5p	85.5103	NM_181781
ZNF326	hsa-miR-4463	85.3683	NM_182975
ZNF326	hsa-miR-373-5p	85.1843	NM_181781
ZNF326	hsa-miR-371b-5p	85.1843	NM_181781
ZNF326	hsa-miR-616-5p	85.1843	NM_181781
ZNF326	hsa-miR-548n	85.1409	NM_182975
ZNF326	hsa-miR-4272	85.084	NM_181781
ZNF326	hsa-miR-138-2-3p	84.5156	NM_181781
ZNF326	hsa-miR-206	84.4458	NM_001320185
ZNF326	hsa-miR-1-3p	84.4458	NM_001320185
ZNF326	hsa-miR-6792-3p	84.44	NM_181781
ZNF326	hsa-miR-4691-5p	84.44	NM_181781
ZNF326	hsa-miR-6739-5p	84.2942	NM_181781
ZNF326	hsa-miR-1299	84.0688	NM_181781
ZNF326	hsa-miR-5590-3p	83.9611	NM_181781
ZNF326	hsa-miR-5587-5p	83.5873	NM_001320185
ZNF326	hsa-miR-151a-3p	83.397	NM_182975
ZNF326	hsa-miR-541-5p	83.3503	NM_181781
ZNF326	hsa-miR-944	83.2382	NM_182975

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Motifs and transcription factors (TFs) regulating ZNF326

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF326	transfac_pro__M04826	EP300 (directAnnotation).
ZNF326	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ZNF326	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ZNF326	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
ZNF326	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ZNF326	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
ZNF326	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
ZNF326	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ZNF326	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ZNF326	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZNF326	jaspar__MA0748.2	YY2 (directAnnotation).
ZNF326	transfac_pro__M01298	MECP2 (directAnnotation).
ZNF326	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ZNF326	metacluster_182.10	ZFX (directAnnotation).
ZNF326	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ZNF326	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZNF326	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZNF326	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZNF326	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZNF326	cisbp__M00788	ZFY (inferredBy_Orthology).
ZNF326	transfac_pro__M00430	E2F1 (directAnnotation).
ZNF326	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF326	transfac_pro__M04893	TAF1 (directAnnotation).
ZNF326	transfac_pro__M01199	TRIM28 (directAnnotation).
ZNF326	metacluster_7.13	ZFX (directAnnotation).
ZNF326	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZNF326	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ZNF326	hdpi__HIP2	UBE2K (directAnnotation).
ZNF326	hdpi__TIMELESS	TIMELESS (directAnnotation).
ZNF326	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZNF326	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZNF326	transfac_pro__M00938	E2F1 (directAnnotation).
ZNF326	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ZNF326	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ZNF326	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZNF326	hdpi__RARA	RARA (directAnnotation).
ZNF326	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
ZNF326	cisbp__M00968	MTF2 (directAnnotation).
ZNF326	transfac_pro__M02898	SMAD3 (directAnnotation).
ZNF326	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZNF326	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ZNF326	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZNF326	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZNF326	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZNF326	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZNF326	hdpi__ZNF304	ZNF304 (directAnnotation).
ZNF326	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZNF326	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZNF326	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF326	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."