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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF322

Summary for ZNF322

Gene information	Gene symbol	ZNF322
	Ensembl ID	ENSG00000181315
	Entrez ID	79692
	Gene name	zinc finger protein 322
	Synonyms	bA457M11.2\|bA457M11.3\|HCG12\|ZNF322A\|ZNF388\|ZNF489
	Gene type	protein_coding
	UniProtAcc	Q6U7Q0

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Dataset with differentially expressed gene: ZNF322

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.357074	0.00e+00

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Expression of ZNF322 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF322

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF322

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF322	hsa-miR-4292	86.7296	NM_024639
ZNF322	hsa-miR-6791-5p	86.7296	NM_024639
ZNF322	hsa-miR-5692a	86.1475	NM_024639
ZNF322	hsa-miR-3646	84.9667	NM_024639
ZNF322	hsa-miR-7162-3p	84.7383	NM_001242797
ZNF322	hsa-miR-4799-5p	84.0884	NM_024639
ZNF322	hsa-miR-3605-5p	83.9788	NM_024639
ZNF322	hsa-miR-342-3p	83.5179	NM_001242797
ZNF322	hsa-miR-3925-5p	82.2737	NM_024639
ZNF322	hsa-miR-10393-5p	82.2485	NM_024639
ZNF322	hsa-miR-6815-3p	81.962	NM_024639
ZNF322	hsa-miR-4424	81.7065	NM_001242797
ZNF322	hsa-miR-6839-3p	80.458	NM_024639
ZNF322	hsa-miR-4724-3p	80.3447	NM_024639

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Motifs and transcription factors (TFs) regulating ZNF322

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF322	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZNF322	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF322	transfac_pro__M07397	ZNF148 (directAnnotation).
ZNF322	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZNF322	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ZNF322	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZNF322	metacluster_7.13	ZFX (directAnnotation).
ZNF322	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ZNF322	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZNF322	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZNF322	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZNF322	tfdimers__MD00151	CHURC1 (directAnnotation).
ZNF322	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZNF322	transfac_pro__M01303	SP1 (directAnnotation).
ZNF322	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF322	transfac_pro__M01714	KLF15 (directAnnotation).
ZNF322	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZNF322	metacluster_3.14	WT1; WT1 (directAnnotation).
ZNF322	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZNF322	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZNF322	transfac_pro__M07436	WT1 (directAnnotation).
ZNF322	transfac_pro__M02281	SP1 (directAnnotation).
ZNF322	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZNF322	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF322	transfac_pro__M02898	SMAD3 (directAnnotation).
ZNF322	transfac_public__M00491	PATZ1 (directAnnotation).
ZNF322	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."